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Traditional Chinese medicine composition for treating avian paramyxovirus type disease and preparation method and application thereof

A myxovirus and composition technology, applied in the field of traditional Chinese medicine composition for the treatment of poultry paramyxovirus disease, can solve the problems of low cure rate, reduced production profit, excessive antibiotic residues, etc., and achieve high bioavailability and easy absorption by livestock and poultry , Excellent clinical effect

Inactive Publication Date: 2019-10-01
烟台海研制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the use of vaccines has played a certain role in preventing and controlling the prevalence of APM, due to the high infectivity of APMV and the complexity of serotypes, the immune prevention is complicated and the cost of prevention is increased, which reduces the production profit
Therefore, APM is still occurring and spreading in immunized and non-immunized flocks, causing serious economic losses to the poultry industry
In terms of chemical drugs, due to the prohibition of chemical antiviral drugs such as ribavirin in food animals, there is no drug for the treatment of APM. The current clinical treatment of this disease is mainly to treat the symptoms, and quinolones, cephalosporins and other antibacterial drugs are mostly used. Anti-inflammation, prevent secondary infection, reduce mortality, which often cause excessive antibiotic residues, threatening human health and life safety
The industry has tried to use traditional Chinese medicine for prevention and treatment. Most of them use expensive Chinese medicinal materials such as Codonopsis pilosula and Pueraria lobata combined with a dozen or even dozens of Chinese herbal medicines. This not only wastes traditional Chinese medicine resources, but also leads to high cost of medication and low cure rate.

Method used

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  • Traditional Chinese medicine composition for treating avian paramyxovirus type disease and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A traditional Chinese medicine composition for treating poultry paramyxovirus disease. The components include 25 parts of Artemisia annua, 30 parts of Woad indigo, 15 parts of Jujube and 10 parts of licorice in parts by weight.

[0029] The preparation method of above-mentioned Chinese medicine composition, the steps are as follows:

[0030] (1) After drying Artemisia sativa, Isatis indigo, jujube and licorice at 60°C, they were crushed at high speed respectively to obtain coarse powders of 60 meshes;

[0031] (2) Add ethanol with 12 times the weight of Artemisia annua coarse powder and a concentration of 65wt%, reflux extraction at 65°C for 2 times, each time for 2.5 hours, and combine the alcohol extract; then filter the alcohol extract, concentrate under reduced pressure, and spray dry , to obtain a Artemisia officinalis extract powder;

[0032] (3) Take the woad indigo meal, Chinese jujube meal and licorice meal in step (1) to obtain a mixture; add water 10 times t...

Embodiment 2

[0035] A traditional Chinese medicine composition for treating poultry paramyxovirus disease. The components include, in parts by weight, 15 parts of Artemisia argyi, 50 parts of Chinese cabbage, 5 parts of Chinese jujube and 15 parts of licorice.

[0036] The preparation method of above-mentioned Chinese medicine composition, the steps are as follows:

[0037] (1) After drying Artemisia sativa, Isatis indigo, Chinese jujube and licorice at 60°C, they were crushed at high speed respectively to obtain 50-mesh coarse powder;

[0038] (2) Add ethanol with 16 times the weight of Artemisia annua coarse powder and a concentration of 70wt%, reflux extraction at 60° C. for 3 times, each time for 3 hours, and combine the ethanol extract; then filter the ethanol extract, concentrate under reduced pressure, and spray dry. Get a stick of Artemisia extract powder;

[0039] (3) Take the woad indigo meal, Chinese jujube meal and licorice meal in step (1) to obtain a mixture; add water 8 tim...

Embodiment 3

[0042] A traditional Chinese medicine composition for treating poultry paramyxovirus disease. The components include, by weight, 45 parts of Artemisia annua, 20 parts of Isatis indica, 25 parts of Chinese jujube and 5 parts of licorice.

[0043] The preparation method of above-mentioned Chinese medicine composition, the steps are as follows:

[0044] (1) After drying Artemisia sativa, Isatis indigo, Chinese jujube and licorice at 60°C, they were crushed at high speed respectively to obtain 50-mesh coarse powder;

[0045] (2) Add ethanol with 16 times the weight of Artemisia annua coarse powder and a concentration of 70wt%, reflux extraction at 60° C. for 3 times, each time for 3 hours, and combine the ethanol extract; then filter the ethanol extract, concentrate under reduced pressure, and spray dry. Get a stick of Artemisia extract powder;

[0046] (3) Take the woad indigo meal, Chinese jujube meal and licorice meal in step (1) to obtain a mixture; add water 8 times the weig...

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Abstract

The invention belongs to the technical field of veterinary traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating an avian paramyxovirus type disease and a preparation method and application thereof. In the preparation method, water extraction and alcohol extraction processes are adopted, active ingredients in Chinese herbal medicines canbe fully extracted, the problems are solved that traditional Chinese medicine powder is high in coarse fiber content, and the active ingredients are difficult to dissolve out, the traditional Chinesemedicine composition is more easily absorbed by livestock and poultry, and the bioavailability is high; the traditional Chinese medicine composition is better in treatment effect on treating the avian paramyxovirus type disease, and the clinical effect can be better exerted. The traditional Chinese medicine composition preparation can be quickly and completely dissolved into drinking water for the livestock and poultry without blocking a farming drinking water system, and it is convenient for a large-scale poultry farm to use; the traditional Chinese medicine composition is prepared from thetraditional Chinese medicine materials which are rich in source and excellent in quality, the source is wide, the cost is low, and the traditional Chinese medicine composition reasonable in formula, easy to prepare, free of pollution, free of drug residues, free of drug tolerance, free of toxicity, definite in treatment effect and high in cure rate, and the disease difficultly recurs after being cured.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine for veterinary use, and in particular relates to a traditional Chinese medicine composition for treating poultry paramyxovirus disease, a preparation method and application thereof. Background technique [0002] Avian paramyxovirus disease (APM) is an acute, subacute and highly contagious infectious disease caused by avian paramyxovirus (Avian Paramyxovirus, APMV), which mainly affects chickens, turkeys, ducks and other poultry. The rate is very high, characterized by dyspnea, diarrhea and neurological symptoms, which affect the laying of eggs; the main pathological changes are mucous membranes, serous hemorrhage and edema in the digestive tract, respiratory tract and heart, and non-suppurative encephalitis changes are often caused in the later stage . The disease can occur throughout the year, and poultry flocks of all ages are susceptible. Once infected, it can spread to th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/725A61P31/14
CPCA61K36/28A61K36/315A61K36/484A61K36/725A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61P31/14A61K2300/00
Inventor 杨磊毛瑞华郝智慧何家康刘洪明李国翔董宏伟袁万哲牛恒刘哲林
Owner 烟台海研制药有限公司
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