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Direct sub-field optimization method and system based on fuzzy entropy

An optimization method, a technology of fuzzy entropy, applied in X-ray/γ-ray/particle irradiation therapy, radiotherapy, mechanical/radiation/invasive therapy, etc., can solve problems such as large amount of calculation

Active Publication Date: 2019-09-27
ZHONGBEI UNIV
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Problems solved by technology

[0007] Aiming at the problems that using local gradient information to generate subfields will easily lead to local optimal results, and using global gradient information to generate subfields will cause a large amount of calculation, the present invention provides a method that can generate deliverable subfields more quickly and accurately. Fuzzy Entropy Direct Subfield Optimization Method and System

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  • Direct sub-field optimization method and system based on fuzzy entropy
  • Direct sub-field optimization method and system based on fuzzy entropy
  • Direct sub-field optimization method and system based on fuzzy entropy

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Embodiment Construction

[0106] A kind of direct sub-field optimization method based on fuzzy entropy of the present invention is implemented according to the following steps:

[0107] Step 1: Input the basic information required for direct subfield optimization, and calculate the gradient matrix of the subfield according to the objective function and other information in the input basic information;

[0108] Set the objective function as follows:

[0109]

[0110] Then the sub-objective function expression is:

[0111]

[0112]

[0113]

[0114]

[0115] f gEUD (D)=H(gEUD(D)-gEUD 0 )·(gEUD(D)-gEUD 0 );

[0116] f TCP (D)=H(TCP 0 -ln(TCP(D))) (TCP 0 -ln(TCP(D)));

[0117] f NTCP (D)=H(ln(1-NTCP 0 )-ln(1-NTCP(D)))(ln(1-NTCP 0 )-ln(1-NTCP(D))); where:

[0118] D(x) is the dose distribution, and D(x)=Wx, that is, the dose distribution is a linear function about the dose deposition matrix W and the fluence matrix x;

[0119] f l (D(x)) is the lth sub-objective function;

[0120...

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Abstract

The method aims at solving the problems that a local optimal result is easily caused when a sub-field is generated by using local gradient information, and the calculated amount is large when the sub-field is generated by using global gradient information. The invention provides a direct sub-field optimization method and system based on fuzzy entropy, and the method and system can generate a deliverable sub-field more quickly and accurately. According to the method, firstly, the sub-field shapes are generated based on the fuzzy entropy segmentation principle, then sub-field weight optimization is carried out to obtain the treatment scheme meeting the clinical requirements, the sub-field shapes can be obtained rapidly and accurately through global gradient information, the plan quality is improved while the calculated amount is reduced, the number of sub-fields obtained through optimization is small, and the optimization efficiency is improved; the sub-field shape is generated by utilizing the global gradient information, so that the dose fitness of the target area is improved, the radiation dose received by organs and normal tissues endangered around the target area is reduced, and the clinical treatment requirements of improving the treatment gain ratio, improving the tumor radiotherapy accuracy and reducing the probability of complications of the normal tissues caused by radiation are met.

Description

technical field [0001] The invention relates to a direct field optimization method and system based on fuzzy entropy, belonging to the technical field of intelligent computing methods. Background technique [0002] Intensity-modulated radiation therapy is widely used in clinical cancer treatment. Intensity-modulated radiation therapy plan optimization adjusts the parameters of the irradiation field so that the shape of the high-dose area is basically consistent with the shape of the target area, and at the same time reduces the radiation dose received by the organs at risk and normal tissues around the target area as much as possible, so as to improve the accuracy of tumor radiation therapy. It is a clinical treatment requirement to reduce the probability of radiation-induced complications in normal tissues. [0003] The most widely used is the MLC intensity modulation technology. MLC intensity modulation technology mainly has two modes: static intensity modulation and dyn...

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Application Information

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IPC IPC(8): G16H20/40A61N5/10
CPCG16H20/40A61N5/1031A61N5/1039
Inventor 张丽媛张鹏程刘祎桂志国孟域朴
Owner ZHONGBEI UNIV
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