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Quick hemostatic patch for nursing in emergency department and preparation method thereof

A rapid and emergency technology, applied in the direction of medical preparations containing active ingredients, blood diseases, pharmaceutical formulas, etc., can solve the problem of slow hemostasis, achieve rapid hemostasis, activate the coagulation system, and improve the effect of hemostasis

Active Publication Date: 2019-09-24
THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the problems raised by the above-mentioned background technology, the invention provides a quick hemostatic patch for emergency care and a preparation method thereof. The quick hemostatic patch has a good hemostatic effect. , Scutellaria baicalensis extracts as raw materials to prepare patches, through the mutual cooperation between Burnet, Scutellaria, and Scutellaria baicalensis, play the role of hemostasis, anti-inflammatory, antibacterial, analgesic, astringent, and activate the blood coagulation system, assisting hydroxymethyl chitosan , played a synergistic effect, added plant starch to quickly absorb the water in the blood, mechanically seal the blood vessel breach, and at the same time, this physical barrier can isolate the wound, play the role of anti-adhesion, can effectively improve the hemostatic effect, and promote Wound healing, can be used in emergency department care to stop bleeding of postoperative wounds, solving the problem that traditional hemostatic patches usually cannot meet the needs of emergency department care due to the slow rate of hemostasis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] In this embodiment, a rapid hemostatic patch for emergency department nursing is composed of a patch and an ointment laid on the patch, and the ointment is composed of the following components in parts by weight: 12 parts of Burnet extract, large 12 parts of thistle extract, 6 parts of baicalin extract, 15 parts of hydroxymethyl chitosan, 4 parts of glycerin, 0.8 part of potato starch;

[0038] The preparation method of described ointment comprises the following steps:

[0039] S1, preparation of Burnet extract

[0040]Dry Burnet and crush it into coarse powder, add a 95% ethanol solution with a mass concentration equivalent to 10 times its total weight, heat and reflux for extraction 3 times, each time for 2.5 hours, combine the extracts, filter, and recover ethanol from the filtrate under reduced pressure , make up distilled water to 10 times the weight of Burnet, adjust the pH value to 4.5 with hydrochloric acid, let it stand, filter out impurities, keep the filtrat...

Embodiment 2

[0048] In this embodiment, a rapid hemostatic patch for emergency department nursing is composed of a patch and an ointment laid on the patch, and the ointment is composed of the following components in parts by weight: 9 parts of Burnet extract, large 15 parts of thistle extract, 10 parts of Scutellaria baicalensis extract, 20 parts of hydroxymethyl chitosan, 5 parts of glycerin, 1 part of sweet potato starch;

[0049] The preparation method of described ointment comprises the following steps:

[0050] S1, preparation of Burnet extract

[0051] After the Burnet is dried, it is crushed into a coarse powder, and a mass concentration of 95% ethanol solution equivalent to 8 times its total weight is added, heated and refluxed for extraction twice, each time for 2 hours, the extracts are combined, filtered, and the filtrate is decompressed to recover ethanol. Add distilled water to 8 times the weight of Burnet, adjust the pH value to 4 with hydrochloric acid, let it stand still, ...

Embodiment 3

[0059] In this embodiment, a rapid hemostatic patch for emergency department nursing is composed of a patch and an ointment laid on the patch, and the ointment is composed of the following components in parts by weight: 15 parts of Burnet extract, large 9 parts of thistle extract, 3 parts of Scutellaria baicalensis extract, 10 parts of hydroxymethyl chitosan, 3 parts of glycerin, 0.5 parts of sweet potato starch;

[0060] The preparation method of described ointment comprises the following steps:

[0061] S1, preparation of Burnet extract

[0062] Dry Burnet and pulverize it into a coarse powder, add a 95% ethanol solution with a mass concentration equivalent to 12 times its total weight, heat and reflux extraction for 3 times, each time for 3 hours, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure. Make up distilled water to 8 times the weight of Burnet, adjust the pH value to 3 with hydrochloric acid, let it stand still, filter ...

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Abstract

The invention relates to an external hemostatic medicine and particularly discloses a quick hemostatic patch for nursing in the emergency department and a preparation method thereof. The quick hemostatic patch consists of a patch body and unguent laid on the patch body, wherein the unguent is prepared from, by weight, 9-15 parts of a radix sanguisorbae extract, 9-15 parts of an artichoke extract, 3-10 parts of a radix scutellariae extract, 10-20 parts of hydroxymethyl chitosan, 3-5 parts of glycerol and 0.5-1 part of plant starch. The patch prepared by the preparation method has a good hemostatic effect, the patch is prepared by taking the sanguisorba officinalis extract, the artichoke extract and the radix scutellariae extract as raw materials, the sanguisorba officinalis, the artichoke and the radix scutellariae cooperate with one another to play the effects of hemostasis, anti-inflammation, antibiosis, analgesia, astringency and activation of a coagulation system, assist the hydroxymethyl chitosan and play a synergistic effect, and the plant starch is added to rapidly absorb water in blood. The hemostatic effect can be effectively improved, wound healing can be promoted, and the quick hemostatic patch can be used for nursing in the emergency department to stop bleeding on postoperative wounds.

Description

technical field [0001] The invention relates to an external hemostatic drug, in particular to a rapid hemostatic patch for emergency care and a preparation method thereof. Background technique [0002] Bleeding patients in the emergency department usually refer to patients with ruptured arteries and rapid blood loss in a short period of time, such as cuts, stab wounds, and hard objects. Hemorrhagic shock; usually, rescuers will use their fingers to press the arteries proximal to the bleeding site against the bones to occlude the blood vessels and interrupt the blood flow to achieve hemostasis. It is a fast, effective and preferred method of hemostasis. After the bleeding is stopped, other effective hemostatic methods should be used according to the specific situation, such as the tourniquet hemostatic method, etc., but the disadvantage of this hemostatic method is that the wound is easily infected, that is to say, although the bleeding is stopped, But it does not have anti...

Claims

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Application Information

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IPC IPC(8): A61K36/739A61K9/70A61P7/04A61P17/02A61K31/722A61K31/718
CPCA61K9/7023A61K31/718A61K31/722A61K36/28A61K36/539A61K36/739A61K2236/333A61K2236/37A61K2236/39A61K2236/51A61P7/04A61P17/02A61K2300/00
Inventor 李洁杨宁波李鹏
Owner THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF SCI & TECH
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