A method for preparing ellagic acid by gallnut, the prepared ellagic acid and its application
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A technology of ellagic acid and gallnut, applied in the field of ellagic acid, can solve problems such as expensive instruments, high industrial production costs, and complexity, and achieve the effects of simple operation, environmentally friendly preparation process, and good yield
Active Publication Date: 2020-11-24
中科萱嘉医养(珠海)健康科技有限公司
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(2) High Performance Liquid Chromatography (HPLC) (especially Reverse Phase-High Performance Liquid Chromatography (RP-HPLC)) is currently the most common method for determining the content of ellagic acid method, the method is simple to operate, requires less sample volume, short measurement time, accurate experimental results and good reproducibility, but the required instruments are relatively expensive
However, in the prior art, the process of preparing ellagic acid from Galla galla is relatively complicated, which makes its industrial production cost relatively high, and it is necessary to further improve it.
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Embodiment 1
[0025] Embodiment 1 of the present invention is: a method for preparing ellagic acid from Galla gall, comprising the following steps:
[0026] (1) Mix 20 g of commercial gallnut powder with 200 mL of deionized water, pour it into a beaker, and stir at room temperature for 2 h.
[0027] (2) Filtrate with a vacuum pump and discard the residue.
[0028] (3) Pour the extract obtained in step (2) into a conical flask, add 1.5 g of sodium persulfate and 1 g of sodium bicarbonate, adjust the pH to 8.5 with 30% sodium hydroxide, and react for 16 hours.
[0029] (4) Adjust the pH to about 4 with concentrated hydrochloric acid, wash with water, centrifuge at 10,000 rpm for 5 minutes, and take the precipitate.
[0030] (5) Obtain ellagic acid solid after drying.
[0031] (6) The above experimental operation was repeated 3 times, and the yields were calculated respectively.
Embodiment 1
[0038] The raw material of embodiment 1 and comparative example 1, product weight information are as shown in table 1 below:
[0039] Table 1
[0040]
[0041] It can be seen from the above table 1 that the scheme of the embodiment of the present invention cleverly replaces the traditional solid-liquid separation filtration method after the acid precipitation process with centrifugation, which avoids that the product sticks to the filter membrane and is difficult to remove when the precipitation is filtered. , which can increase the yield by more than 10%.
Embodiment 2
[0042] Embodiment 2 of the present invention is: a method for preparing ellagic acid by using Galla chinensis, which differs from Embodiment 1 only in that the amount of sodium persulfate added is 1 g, and the mass of sodium bicarbonate is 0.67 g.
[0043] The yield calculated by weighing is 44.3%.
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Abstract
The invention discloses a method for preparing ellagic acid by using Rhus chinensis Mill., the prepared ellagic acid and application of ellagic acid. The method comprise the following steps: (1), mixing Rhus chinensis Mill. powder with deionized water at room temperature, performing stirring for 1-3 hours, performing filtration, and taking the supernatant; and (2), taking the obtained supernatant,adding sodium persulfate and sodium hydrogencarbonate sequentially, adjusting the pH value to 8-9, performing still standing for 10-20 hours at room temperature, then adjusting the pH value to 3-6 byusing inorganic acid, performing solid-liquid separation, and collecting the solid which is the ellagic acid, wherein the addition amount of sodium persulfate is 5-10% of the mass of the Rhus chinensis Mill., and the mass ratio of the added sodium persulfate to sodium hydrogencarbonate is 3:2. Water and Rhus chinensis Mill. are mixed firstly so as to extract tannic acid, the ellagic acid is obtained through oxidation, alkalization and acidification, and all the operation can be carried out at normal temperature and normal pressure; and the reaction conditions are mild, the operation is simple, the obtained product has high purity and good yield, and the method has good application prospects.
Description
technical field [0001] The invention relates to the technical field of organic synthesis, in particular to a method for preparing ellagic acid by using gallnuts, the prepared ellagic acid and an application thereof. Background technique [0002] The scientific name of gallnut (Rhus chinensis Mill.), also known as Baichongcang, Baiyaojian, and Gallia, is a female horned aphid or aphid of the family Aphididae of the order Homoptera that parasitizes the plant "Saltwood" and its The young leaves or petioles of other plants of the same genus are stabbed to form a cystic aggregate of galls, which is obtained after roasting and drying. In addition, Galla is also a kind of medicinal material, which can treat many diseases. The main production areas of Chinese Gallnut are concentrated in Qinling Mountains, Daba Mountains, Wudang Mountains, Wushan Mountains, Wuling Mountains, Emei Mountains, Dalou Mountains, Daliang Mountains and other mountainous and hilly areas. The vertical distr...
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