Methods of treating cancer

Abstract

The invention relates to methods of treating cancer in a subject in need thereof, e.g., in a human in need thereof, comprising determining determining the level of 5- Methylthioadenosine phosphorylase(MTAP) polynucleotide or polypeptide or the presence or absence of a mutation in MTAP in a sample from the human, and administering to the human an effective amount of a Type I protein arginine methyltransferase (Type I PRMT) inhibitor if the level of the MTAP polynucleotide or polypeptide is decreased relative to a reference or if a mutation in MTAP polynucleotide or polypeptide is present, thereby treating the cancer in the human.

Description

Technical field [0001] The present invention relates to methods of treating cancer in a subject in need. Background technique [0002] Effective treatment of hyperproliferative diseases, including cancer, is an ongoing goal in the field of oncology. Generally, cancer is caused by a disorder of the normal processes that control cell division, differentiation, and apoptotic cell death, and is characterized by the proliferation of malignant cells, which have the potential for unlimited growth, local expansion, and systemic metastasis. Disorders of normal processes include abnormalities in signal transduction pathways and responses to factors different from those found in normal cells. [0003] The expanded development and use of targeted therapies for cancer treatment reflects the growing understanding of key carcinogenic pathways and how targeted perturbations of these pathways correspond to clinical responses. The difficulty in predicting the efficacy of targeted therapies may be ...

AI Technical Summary

Problems solved by technology

In many of these experimental systems, disruption of PRMT1-dependent ADMA modification of its substrates reduced the proliferative capacity of cancer cells (Yang, Y. & Bedford, M.T. Protein arginine methyltransferases and cancer. Nat Rev Cancer 13, 37-50, doi: 10.1038 / nrc3409(2013))

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