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Drug-modified intraocular lens and preparation method and application thereof

An intraocular lens and drug technology, which is used in drug combinations, pharmaceutical formulations, prostheses, etc.

Inactive Publication Date: 2019-09-10
THE EYE HOSPITAL OF WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pathogenesis of PCO is not yet clear, and there is no mature theory to predict its occurrence and development

Method used

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  • Drug-modified intraocular lens and preparation method and application thereof
  • Drug-modified intraocular lens and preparation method and application thereof
  • Drug-modified intraocular lens and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of the intraocular lens of embodiment 1 drug modification

[0043] The medicine used in the present invention is Y27632, empirical molecular formula C 14 h 21 N 3O.2HCl, molecular weight: 320.26. Molecular structure such as figure 1 shown.

[0044] The modification material used in the present invention is polylactic acid-glycolic acid copolymer, linear molecular formula [C 3 h 4 o 2 ] x [C 2 h 2 o 2 ] y , lactic acid: glycolic acid 50:50, molecular weight: 24,000-38,000, molecular structure formula such as figure 2 shown.

[0045] 1. Preparation of main reagents

[0046] (1) Y27632 solution: 1 mg of Y27632 powder was added to 78.04 μl of sterilized double distilled water to prepare a concentration of 40 mM, and stored at 4°C.

[0047] (2) 1% PLGA solution: 1 mg of PLGA powder was dissolved in 0.1 ml of chloroform, and stored at -20°C.

[0048] 2. Intraocular lens simulation material modification

[0049] Take out the intraocular lens, ...

Embodiment 2

[0052] The drug effect of the intraocular lens modified by the drug of embodiment 2

[0053] 1.1 In vitro release test

[0054] Take sterile 1.5ml centrifuge tubes, add 1.0ml of sterilized PBS to each tube, place the drug-modified IOL in PBS, and shake on a constant temperature shaker at 37°C at a frequency of 100rpm for 15min, 30min, 1h, At 2h, 4h, 8h, 12h, 24h, and 48h, take out 200ul of the solution to a sterile centrifuge tube, then add 200ul of sterilized PBS, and put it back on the shaker. After 48 hours of testing, all samples were collected for testing. After zeroing the UV spectrophotometer equipment with PBS, carry out absorbance scanning at 200-800nm ​​wavelength on the solution of Y27632 gradient dilution (40μM, 20μM, 10μM, 5μM, 2.5μM, 1.35μM, 0.625μM, 0.3125μM, 0.15625μM) , used to make the standard curve of drug standards, the measurement sequence is from low concentration to high concentration. Then carry out the absorbance scanning of 200-800nm ​​wavelength ...

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Abstract

The invention discloses a drug-modified intraocular lens and a preparation method and application thereof. According to the intraocular lens, by researching the effect of a signal path on proliferation and migration of lens epithelial cells, a drug with a prevention and treatment effect on posterior capsule opacification after cataract surgery is screened out. It is found that an inhibitor of a ROCK signal path has an influence on the proliferation and migration of the lens epithelial cells, and the drug-modified intraocular lens is provided by improving a drug feeding mode. The intraocular lens can relatively controllably release the explosive drug in the early stage; moreover, by slowly releasing the drug in the later stage, the intraocular lens integrally has the advantages of great biocompatibility and good prevention and treatment effect.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a drug-modified intraocular lens and its preparation method and application. Background technique [0002] Posterior capsular opacity (PCO), also known as posterior capsular opacity, is the main cause of vision loss after cataract surgery, which seriously affects the curative effect of surgery. Studies have shown that the incidence of PCO 3 years after cataract surgery is significantly increased, but there is no significant difference between the incidence of PCO 3 years and 5 years after surgery. Fong et al. conducted a study on 1495 patients and found that the incidence of PCO in 3 years after cataract surgery was about 38.5%, and the analysis of related influencing factors found that young doctors, rounded-corner designed intraocular lens (Intraocular lens, IOL) and Higher incidence of PCO was associated. In addition, another report stated that the proportion of Nd-YAG laser pos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/4409A61P27/12A61L27/34A61L27/54
CPCA61K31/4409A61K45/00A61L27/34A61L27/54A61L2300/204A61L2300/416A61L2300/606A61L2430/16A61P27/12C08L67/04
Inventor 赵云娥林磊林全愧常平骏
Owner THE EYE HOSPITAL OF WENZHOU MEDICAL UNIV
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