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Application of euscaphis konishii hayata extract to preparation of hypolipidemic drugs

A technology of Corvus sinensis and blood lipid-lowering drugs, which is applied in the field of the preparation of Corvus sinensis extracts in the preparation of hypolipidemic drugs, can solve the problems of less research on medicinal value, and achieve the improvement of adipose tissue and cell morphology , control weight, control abnormal increase effect

Inactive Publication Date: 2019-09-06
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Corvus japonica is a traditional Chinese herbal medicine, which mainly treats stomach pain, bruises, rheumatism pain, dizziness, diarrhea, dysentery, etc., while Corvus dentata is mainly used as an ornamental plant, and there are few studies on its medicinal value at present. two plants of the same genus

Method used

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  • Application of euscaphis konishii hayata extract to preparation of hypolipidemic drugs
  • Application of euscaphis konishii hayata extract to preparation of hypolipidemic drugs
  • Application of euscaphis konishii hayata extract to preparation of hypolipidemic drugs

Examples

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Effect test

Embodiment 1

[0019] Take the dry pericarp of Arvenia crenidae, chop it into pieces, dry it at 50°C, and pulverize it to obtain powder. Add 10 times of 95vol% ethanol according to the weight ratio, heat to 80°C and reflux for extraction twice, extract for 2 hours each time, combine the extracts, recover the ethanol and concentrate under reduced pressure until there is no alcohol smell, dry to obtain the fruit cortitol Extract. After dissolving the alcoholic extract of the pericarp of S. crenidae in water, load the sample onto a macroporous resin chromatography column, wash off unadsorbed substances with water, and then elute with 10vol%-100vol% ethanol solution, and use a thin-layer chromatography plate Detect until there is no obvious sample on the thin layer chromatography, collect the eluent, concentrate under reduced pressure, and dry to obtain the extract of the fruit bark of S. crebatus.

Embodiment 2

[0021] Take the dried twigs of Toonia sylvatica, chop them into pieces, dry them at 50°C, and pulverize them to obtain powder. Add 10 times of 95vol% ethanol according to the weight ratio, heat to 80°C and reflux for extraction twice, each extraction for 2 hours, combine the extracts, recover the ethanol and concentrate under reduced pressure until there is no alcohol smell, dry, and obtain the sarcocarpus ethanol Extract. After dissolving the ethanol extract of the twigs of Jacuba dentata in water, load the sample onto the macroporous resin chromatography column, wash off the unadsorbed substances with water, and then elute with 10vol%-100vol% ethanol solution, and use the thin-layer chromatography plate Detect until there is no obvious sample on thin-layer chromatography, collect the eluate, concentrate under reduced pressure, and dry to obtain the extract of Takaya dentata twigs.

Embodiment 3

[0023] Take the dried leaves of S. crenariae, chop them up, dry them at 50° C., and pulverize them to obtain powder. According to the weight ratio, add 10 times of ethanol with a volume concentration of 95vol% and heat it to 80°C for reflux extraction twice, each extraction for 2 hours, combine the extracts, recover the ethanol and concentrate under reduced pressure until there is no alcohol smell, and dry to obtain the jay. Alcoholic extract of Tsubaki leaves. After dissolving the alcohol extract of the leaves of S. dentata in water, load the sample onto a macroporous resin chromatography column, wash off the unadsorbed substances with water, and then elute with 10vol%-100vol% ethanol solution, and use a thin-layer chromatography plate Detection is carried out until there is no obvious sample on the thin layer chromatography, the eluate is collected, concentrated under reduced pressure, and dried to obtain the extract of the leaves of Coryda sinensis.

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Abstract

The invention relates to application of euscaphis konishii hayata extract to preparation of hypolipidemic drugs. According to an ethanol extraction and macroporous adsorption resin extraction preparation method, the euscaphis konishii hayata extract is obtained and capable of effectively inhibiting abnormal weight increase of hyperlipidemia model mice, reducing contents of TC (total cholesterol),TG (triglyceride) and LDL-C (low-density lipoprotein cholesterol) in serum of the hyperlipidemia mice and increasing the content of HDL-C (high-density lipoprotein cholesterol). By observation of liver tissue pathological sections of each group of mice, the euscaphis konishii hayata extract is capable of improving hepatic adipose tissue and cell morphology changes, so that the euscaphis konishii hayata extract has a remarkable hypolipidemic function and can be applied to preparation of medicines for prevention and treatment of hyperlipidemia.

Description

technical field [0001] The invention belongs to the field of extraction and application of plant active substances, and in particular relates to the application of the extract of Jacuna dentata in the preparation of blood lipid-lowering medicine. Background technique [0002] In recent years, due to the rapid development of China's economy, people's material living standards have been greatly improved, and the population of hyperlipidemia has developed rapidly. According to statistics, the population of hyperlipidemia in China has reached 600 million people, accounting for more than 40% of the total. Hyperlipidemia is an important risk factor for arteriosclerosis, cardiovascular disease, and brain disease. It is also an inducement for chronic diseases such as liver fibrosis, fatty liver, and pancreatitis. It has become one of the major hazards to the health of the Chinese population. At present, the treatment of hyperlipidemia is mainly divided into two categories, one is to...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P3/06
CPCA61K36/185A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61P3/06
Inventor 黄维邹双全邹小兴倪林陈路遥冯翯
Owner FUJIAN AGRI & FORESTRY UNIV
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