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Preparation method and detection method of Dipsacus standard decoction

A detection method and technology for decoction, which are applied in the field of preparation of continuous standard decoction, can solve the problems of insufficient quality and cannot reflect the quality of continuous standard decoction as a whole, and achieve good specificity and relative retention of characteristic maps. Time and relative peak areas are stable and reproducible

Active Publication Date: 2022-03-11
GUOYAOJITUAN TONGJITANG (GUIZHOU) PHARMA CO LTD +2
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  • Claims
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Problems solved by technology

[0005] At present, the methods for controlling the quality of Dipsacus formula granules in the prior art are mainly the determination of the content of Dipsacus saponin VI by high-performance liquid chromatography and the thin-layer identification of alkaloid components. The quality control is not comprehensive enough and cannot be obtained from As a whole, it reflects the quality of the standard decoction of Dipsacus, and thus cannot provide a reference for the quality control of Dipsacus formula granules

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  • Preparation method and detection method of Dipsacus standard decoction
  • Preparation method and detection method of Dipsacus standard decoction
  • Preparation method and detection method of Dipsacus standard decoction

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preparation example Construction

[0138] As mentioned above, the present invention provides a kind of preparation method of standard decoction of dipsacrum, it comprises the following steps:

[0139] (1) Take Dipsacus medicinal material, add water to decoct, filter to obtain filtrate;

[0140] (2) Concentrating and drying the filtrate in step (1), and then freeze-drying. The freeze-drying is divided into three stages: a. pre-freezing: the pre-freezing temperature is -50 ° C ~ -45 ° C; The temperature is -20°C to 0°C; c. Secondary drying: the drying temperature is 5 to 25°C to obtain the Dipsacus standard decoction.

[0141] In a preferred specific embodiment of the present invention, wherein, in step (1), before adding water, the Dipsacus medicinal material needs to be washed, soaked and sliced, soaked after adding water, and before decocting. The time is 30 minutes.

[0142] In a preferred specific embodiment of the present invention, wherein, in step (1), the filtering is hot filtering, and the filtering i...

Embodiment 1

[0181] 1. The preparation method of Dipsacus standard decoction

[0182] (1) Take 100g of Dipsacus decoction pieces, add water to decoct twice, add 10 times the amount of water to the first decoction, soak for 30 minutes and start decocting, turn on strong fire (500W), after boiling, adjust to simmering fire (200W) for decoction For 30 minutes, filter with a 300-mesh filter cloth while it is hot, cool the filtrate in a water bath, add 7 times the amount of water to the second decoction, turn on a strong fire (500W), after boiling, adjust to a simmering fire (200W) and decoct for 20 minutes, and use a 300-mesh filter cloth while it is hot filter cloth to filter, and combine the two filtrates;

[0183] (2) Transfer the filtrate to a rotary evaporator for concentration (water bath temperature: 65°C, vacuum degree is -0.08~-0.09MPa), concentrate to a density of 1.03g / ml, adjust the solid content to 13%, and then transfer to a vacuum In the freeze dryer, pre-freeze first, the pre-...

Embodiment 2

[0306] 1. The preparation method of Dipsacus standard decoction

[0307] (1) Take 100g of Dipsacus decoction pieces, add water to decoct twice, add 10 times the amount of water to the first decoction, soak for 30 minutes and start decocting, turn on strong fire (500W), after boiling, adjust to simmering fire (200W) for decoction For 30 minutes, filter with a 300-mesh filter cloth while it is hot, add 7 times the amount of water to the second decoction, turn on a strong fire (500W), after boiling, adjust to a simmering fire (200W) and cook for 20 minutes, and filter with a 300-mesh filter cloth while it is hot , combined two filtrates;

[0308] (2) Transfer the filtrate to a rotary evaporator for concentration (water bath temperature: 50°C, vacuum degree is -0.08~-0.09MPa), concentrate to a density of 1.04g / ml, adjust the solid content to 14%, and then transfer to a vacuum In the freeze dryer, pre-freeze first, the pre-freeze temperature is -50°C, the pre-freeze time is 5h, an...

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Abstract

The invention relates to the field of traditional Chinese medicine modernization, in particular to a preparation method and a detection method of a Dipsacus standard decoction. The invention provides a preparation method of Dipsacus standard decoction, which comprises the following steps: taking the Dipsacus medicinal material, decocting it with water, and filtering to obtain a filtrate; Stage: a. Pre-freezing: Pre-freezing temperature is -50°C ~ -45°C; b. Primary drying: Drying temperature is -20°C ~ 0°C; c. Secondary drying: Drying temperature is 5 ~ 25°C, to obtain continuous Dipsacan standard decoction, the ointment rate of said Dipsacan standard decoction is 32.30-59.98%. After 6 months of accelerated stability test, the content is relatively stable, the moisture content is relatively stable, moisture absorption is resistant, and no impurity components are produced; the present invention Provides detection methods for the mass content, transfer rate, and characteristic spectrum of Dipsacus saponin VI, with good specificity, good repeatability, and good stability. It provides standards for the quality of traditional Chinese medicine formula granules, and realizes the quality control and effectiveness of traditional Chinese medicine formula granules. supervision.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine modernization, in particular to a preparation method and detection method of Dipsacus standard decoction. Background technique [0002] The traditional Chinese medicinal material Dipsacus is the dried root of Dipsacus asperWall.ex Henry, also known as the monk's head. , strong bones, continuous fractures, stop metrorrhagia, can be used to treat soreness of the waist and knees, rheumatic arthralgia, metrorrhagia, fetal leakage, and injuries caused by falls. [0003] Standard decoction, also known as standard decoction, is a traditional form of medicine widely used in clinical practice. Standard decoction follows the theory of traditional Chinese medicine, standardizes decoction according to clinical decoction decoction methods, separates solid and liquid, and is prepared by appropriate concentration or It is prepared by drying in an appropriate method, and is used as a standard referenc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 孙宜春朱鹤漆正方李慧馨安跃谢隼张建锋娄涛涛张锋潘仁锋林必芬
Owner GUOYAOJITUAN TONGJITANG (GUIZHOU) PHARMA CO LTD
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