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Method for synthesizing low-conductivity amide compound aqueous solution

A technology of amide compound and synthesis method, which is applied in the field of synthesis of low-conductivity amide compound aqueous solution, can solve the problems of long reaction time, high product conductivity, high post-processing cost, etc., and meet the needs of high-end customers and low impurity content Effect

Inactive Publication Date: 2019-08-23
英德市云超聚合材料有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the industry mainly uses the microbial method to synthesize acrylamide under the reaction conditions of normal temperature and pressure, which has disadvantages such as long reaction time, high bacterial dosage, high product conductivity, and high product post-processing cost.

Method used

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  • Method for synthesizing low-conductivity amide compound aqueous solution
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  • Method for synthesizing low-conductivity amide compound aqueous solution

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preparation example Construction

[0029] The embodiment of the present invention provides a method for synthesizing an aqueous solution of a low-conductivity amide compound, which includes the following steps:

[0030] In a solution system in which a biocatalyst with nitrile hydratase activity exists, the corresponding amide compound is synthesized from the nitrile compound, and the temperature during the synthesis process is 9-14°C.

[0031] The embodiment of the present invention provides a method for synthesizing an aqueous solution of a low-conductivity amide compound. The corresponding amide compound is synthesized from a nitrile compound in the presence of a biocatalyst with nitrile hydratase activity, and the temperature during the reaction is controlled to be 9-14°C The inventors found that: when the temperature is lower than 9-14°C, the enzyme activity in the biocatalyst with nitrile hydratase activity is lower, and the yield of the resulting aqueous solution of amide compound is smaller. When the temperatu...

Embodiment 1

[0048] A 42% acrylamide aqueous solution is planned to synthesize 500g. It needs 156.8g of acrylonitrile as raw materials, 343.2g of pure water, and the pH is controlled within the range of 7.0-7.5.

[0049] (1) Pour 62-68 parts by weight of water into a 500ml four-necked flask. Use an electronic balance to weigh the planned amount of acrylonitrile and pour it into a 100ml cylindrical separatory funnel for later use. Install experimental equipment;

[0050] (2) Turn on the electric mixer and set the speed to 60-80r / min;

[0051] (3) Use a pH meter to measure the pH of pure water, and add 8%-12% NaOH solution to adjust the pH to 7.5-8.0;

[0052] (4) Add 0.15-0.4 parts by weight of Nocardia to a 500ml volumetric flask;

[0053] (5) Add ice cubes to the water bath and cool down to 10-12°C in the experiment;

[0054] (6) After the bacteria are added and stirred for 8-12 minutes, the pH is measured, and the pH is controlled at 7.0-7.5. If it is not in this range, add an appropriate amount...

Embodiment 2

[0062] A 50% acrylamide aqueous solution is planned to synthesize 500g. The raw materials required are 187.0g of acrylonitrile, 313.0g of pure water, and the pH is controlled within the range of 7.0-7.5.

[0063] (1) Pour 62-68 parts by weight of water into a 500ml four-necked flask. Use an electronic balance to weigh the planned amount of acrylonitrile and pour it into a 100ml cylindrical separatory funnel for later use. Install experimental equipment;

[0064] (2) Turn on the electric mixer and set the speed to 60-80r / min;

[0065] (3) Use a pH meter to measure the pH of pure water, and add 8%-12% NaOH solution to adjust the pH to 7.5-8.0;

[0066] (4) Add 0.15-0.4 parts by weight of Nocardia to a 500ml volumetric flask;

[0067] (5) Add ice cubes to the water bath and cool down to 10-12°C in the experiment;

[0068] (6) After the bacteria are added and stirred for 8-12 minutes, the pH is measured, and the pH is controlled at 7.0-7.5. If it is not in this range, add an appropriate a...

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Abstract

The invention discloses a method for synthesizing a low-conductivity amide compound aqueous solution. The method for synthesizing the low-conductivity amide compound aqueous solution comprises the following steps that in a solution system with a biocatalyst with nitrile hydratase activity, a corresponding amide compound is synthesized from a nitrile compound, and the temperature in the synthesis process ranges from 9 DEG C to 14 DEG C. According to the method, acrylamide is synthesized through a microbiological method at a low temperature; for a 42% acrylamide product, the by-product crylic acid content is low (0.0846%), and the conductivity of the product is 400 micro Scm<-1>.

Description

Technical field [0001] The present invention relates to the technical field of the manufacture of acrylamide aqueous solutions, and in particular to a method for synthesizing low-conductivity amide compound aqueous solutions. Background technique [0002] At present, the main substrate for the production of acrylamide is acrylonitrile, which is highly toxic and volatile. Inhalation of the human body mainly causes neurological damage and is a carcinogen. The method for producing acrylamide from acrylonitrile is a hydration reaction, where water and acrylonitrile are used as reactants to hydrate to produce acrylamide. The catalyst is an important factor affecting the hydration reaction. The mainstream catalyst of acrylamide has undergone three transformations since the emergence of acrylamide. First, it was prepared by hydration with sulfuric acid as a catalyst; afterwards, the hydration method with copper as the catalyst was improved; the latest and most efficient method is the m...

Claims

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Application Information

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IPC IPC(8): C12P13/02C12R1/365
CPCC12P13/02
Inventor 黄云超伍焯华陈循军周向阳岳志毅
Owner 英德市云超聚合材料有限公司
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