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A leukocyte filter membrane and preparation method thereof

A filter membrane and white blood cell technology, applied in the field of white blood cell filtration, can solve problems such as blood contamination of red blood cells, health threats and injuries of blood recipients, and achieve the effects of alleviating blood condensation, preventing blood condensation, and improving filtration rates

Active Publication Date: 2021-10-15
广州达济医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the combined filter membrane is prone to blood pollution and red blood cell damage defects during the filtration process, which leads to the introduction of bacteria into the body of the blood recipient, which poses a greater threat to the health of the blood recipient

Method used

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  • A leukocyte filter membrane and preparation method thereof
  • A leukocyte filter membrane and preparation method thereof
  • A leukocyte filter membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1, the preparation of amino acid-polylactic acid-glycolic acid copolymer

[0043] a. Add glycolide and D, L-lactide into the reaction kettle and mix them. The weight ratio of the glycolide and D, L-lactide is 1:4 to obtain mixture I, and then add maltotriose Mix with stannous octoate, the weight ratio of the maltotriose to the mixture I is 0.05:1, the added amount of the stannous octoate is 0.4wt% of the total weight of the mixture I, nitrogen gas 3min, then vacuum 10min, Heat to 90°C, react for 5h;

[0044] b. After repeating nitrogen flow and vacuuming 4 times, maintain vacuuming for 30 minutes, place the reaction kettle in an oven at 200°C for 6 hours, cool down, add N,N-dimethylformamide solution with a volume concentration of 70% to dissolve, The solid-to-liquid ratio of the N,N-dimethylformamide solution to the mixture I is 1g:16ml, and then adding absolute ethanol for precipitation to obtain a reticular polylactic acid-glycolic acid copolymer;

[004...

Embodiment 2

[0046] Embodiment 2, the preparation of cationic polyepoxysuccinic acid

[0047] A. maleic anhydride is added to dissolve in water, the molar ratio of maleic anhydride to water is 1:9, sodium hydroxide is added to adjust the pH value to 5~6, to obtain maleic acid solution;

[0048] B. Add sodium tungstate to maleic acid solution, heat to 90°C, and continuously add aqueous hydrogen peroxide solution with a volume concentration of 35%. The amount of aqueous hydrogen peroxide added is the total amount of maleic acid solution 1.5 times the volume, the addition time is 50 minutes, and sodium hydroxide is added at the same time to adjust the pH value to 5-6 to obtain sodium epoxysuccinate;

[0049] C. Add calcium hydroxide to the sodium epoxysuccinate obtained in step B and polymerize at 100°C for 100 minutes. The weight ratio of sodium epoxysuccinate to calcium hydroxide is 1:0.8, acidify to obtain polyepoxysuccinic acid ;

[0050] D. When the temperature of the polyepoxysuccinic...

Embodiment 3

[0051] Embodiment 3, a kind of leukocyte filter membrane

[0052] The leukocyte filtration membrane is composed of the following preparation raw materials and parts by weight thereof:

[0053] 120 parts of amino acid-polylactic acid-glycolic acid copolymer, 20 parts of pullulan, 12 parts of sodium lipoate and 15 parts of cationic polyepoxysuccinic acid; the amino acid-polylactic acid-glycolic acid copolymer is made in Example 1 The obtained amino acid-polylactic acid-glycolic acid copolymer; the cationic polyepoxysuccinic acid is the cationic polyepoxysuccinic acid prepared in Example 2.

[0054] Preparation:

[0055] S1 Add amino acid-polylactic acid-glycolic acid copolymer and pullulan to water, stir evenly, mixed solution I;

[0056] S2 Add lipoic acid sodium and cationic polyepoxysuccinic acid into water, stir until completely dissolved to obtain mixed solution II;

[0057] S3 Mix the mixed solution I obtained in step S1 with the mixed solution II obtained in step S2 to...

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Abstract

The invention belongs to the technical field of leukocyte filtration, and in particular relates to a leukocyte filtration membrane and a preparation method thereof. The leukocyte filtration membrane provided by the invention is mainly composed of amino acid-polylactic acid-glycolic acid copolymer, pullulan, sodium lipoate and cationic polyepoxysuccinic acid. The white blood cell filter membrane prepared by the present invention can effectively inhibit the hemolysis of red blood cells in the blood, and it also has the advantages of strong binding force and high stability. prevent blood pollution; at the same time, the leukocyte filter membrane provided by the present invention has a high filtration rate of leukocytes and platelets, and can alleviate or prevent blood condensation during the process of blood filtration, dredging the blockage of the filter membrane aperture, and ensuring blood The filtration quality of leukocytes can also prolong the service life of the leukocyte filter membrane, which is an ideal leukocyte filter membrane.

Description

technical field [0001] The invention belongs to the technical field of leukocyte filtration, and in particular relates to a leukocyte filtration membrane and a preparation method thereof. Background technique [0002] It is of great significance to filter out white blood cells and platelets in blood preparations before blood transfusion. Because in the medical process of blood transfusion, a variety of side effects of blood transfusion often occur. The root cause is that the transfusion of whole blood or blood components containing leukocytes can cause non-hemolytic febrile reaction, human leukocyte antigen alloimmunization, transfusion-associated viral infection and post-transfusion transplantation. Adverse transfusion reactions such as drug-versus-host disease. At the same time, platelets can induce the body to produce anti-platelet antibodies, which are autoantibodies that do not recognize their own tissues and organs and will attack their own tissues and organs, thereby...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D67/00B01D69/02B01D71/56A61M1/02
CPCA61M1/0281A61M2202/0427A61M2202/0439B01D67/0002B01D69/02B01D71/56B01D2325/36A61M2202/0085
Inventor 王新平
Owner 广州达济医学科技有限公司
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