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Application of cinnamon essential oil

A technology of cinnamon essential oil and cinnamon, which is applied in the field of biomedicine to achieve the effects of improving biological activity, long half-life, and improving metabolic stability

Inactive Publication Date: 2019-08-23
东莞怀朴植物精油有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Previously, this pharmacological effect has not been reported

Method used

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  • Application of cinnamon essential oil
  • Application of cinnamon essential oil
  • Application of cinnamon essential oil

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Experimental program
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preparation example Construction

[0042] The preparation method of the cinnamon essential oil of the present invention comprises steam distillation extraction and carbon dioxide supercritical extraction.

[0043] The cinnamon essential oil of the present invention is detected by gas chromatography-mass spectrometry, and its component ratios are trans-cinnamaldehyde (E-cinnamaldehyde) (>60%), α-piperene (α-piperene) by mass percentage. -cubebene) (>10%), δ-cadinene (>6%), α-muurolene (>5%).

Embodiment 1

[0045] Take cinnamon (Cinnamomum cassia Presl) fresh or dried bark, branches, stems or leaves 100Kg, place in a heap for 2 days, crush to 50 mesh coarse particles, soak the coarse particles in 8 mass times the pH value of 5.0 hydrochloric acid aqueous solution , leached overnight. 0.8% cellulase and 0.3% pectinase were added to the extraction mixture by mass percentage, and enzymolysis was carried out at 37° C. for 2.5 hours. Put the above sample and its mixture into a steam distillation extraction apparatus, reflux extraction at 110°C for 7 hours, collect the distillate, cool it to room temperature, and place it in an oil-water separator for separation. The oil layer is dried with anhydrous sodium sulfate and separated to obtain cinnamon essential oil.

Embodiment 2

[0047] Take cinnamon (Cinnamomum cassia Presl) fresh or dried bark, branches, stems or leaves 50Kg, place in a heap for 2 days, crush to 50 mesh coarse particles, soak the coarse particles in 8 mass times the amount of pH value of 5.0 hydrochloric acid aqueous solution , leached overnight. 0.8% cellulase and 0.3% pectinase were added to the extraction mixture by mass percentage, and enzymolysis was carried out at 37° C. for 2.5 hours. Put the above sample and its mixed solution into a carbon dioxide supercritical extraction instrument. The extraction temperature is 46°C, the pressure is 15.70MPa, the time is 85min, and the flow rate of carbon dioxide is 30kg / h; the essential oil is collected and refined in a molecular distillation instrument. The feed temperature was 43°C, the injection speed was 510mL / h, the first stage evaporation temperature was 112°C, and the second stage evaporation temperature was 63°C, and the second stage distillation part was collected to obtain cinna...

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Abstract

The invention discloses application of cinnamon essential oil. The cinnamon essential oil can be used for preparing medicine for treating or preventing brain function diseases or disordered brain function diseases and health products for relieving brain function diseases or disordered brain function diseases. The novel purpose of the cinnamon essential oil on medicine or great health products showing activity in experiment animal brain function diseases or disordered brain function diseases is discovered for the first time; the condition that the cinnamon essential oil or composition containing cinnamon essential oil or free cinnamon essential oil compositions can relieve the brain function or disordered brain function animal diseases such as senile dementia, depression and anxiety in animal in vivo models is discovered for the first time. Compared with the existing medicine for treating brain functions and disordered brain functions, the cinnamon essential oil and free compositions ofthe cinnamon essential oil have the mechanism of multimolecular cooperated action on multiple points of inhibiting choline esterase, regulating neurotransmitters and the like; good pharmacokinetics parameters are realized; the blood brain barrier penetration is easy, so that the cinnamon essential oil has the characteristics of high toxicology safety, stable metabolism, long half-time and small side effects.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of cinnamon essential oil in the preparation of medicines and health products for treating and preventing brain function and its disorders. Background technique [0002] Cinnamon cassia (Cinnamomum cassia Presl), a lauraceae plant, is currently mainly cultivated in Guangxi, Guangdong, and also in Yunnan, Hainan, Zhejiang and other provinces. The dried bark of cinnamon is a rare and precious Chinese medicinal material. It has been included in the herbal medicine of all dynasties, and it was first recorded in "Shen Nong's Materia Medica", and it was listed as the top grade. It has been recorded in the "Pharmacopoeia of the People's Republic of China" over the years that cinnamon has the effects of nourishing fire and supporting yang, igniting fire and returning to the original, dispelling cold and relieving pain, and warming the meridians. It is used for the tr...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61P25/00A61K8/9789A61Q19/10A61Q19/00A61K125/00
CPCA61K8/9789A61K36/54A61K2236/19A61K2236/37A61P25/00A61Q19/00A61Q19/10
Inventor 许敏韩佳欣陈淑霞曹海龙罗道玉郑三会李云辉顾培爽宋晖
Owner 东莞怀朴植物精油有限公司
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