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Facility for extracting dihydroartemisinic acid from waste oil generated in artemisinin production

A technology of dihydroartemisinic acid and artemisinin, applied in the separation/purification of carboxylic acid compounds, organic chemistry, etc., can solve the problems of unfavorable industrial production of dihydroartemisinic acid, complex process routes, and low product quality. Achieve the effects of easy industrialization and promotion, good filtering effect and short filtering time

Pending Publication Date: 2019-08-20
HUNAN AGRICULTURAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] There are not many special equipment for extracting dihydroartemisinic acid from waste oil produced by artemisinin. If conventional chemical extraction equipment is used, it will easily lead to poor product quality, complicated process route, high cost, and special production equipment is required, which is harmful to the environment. Harmful and other issues are not conducive to the industrial production of dihydroartemisinic acid

Method used

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  • Facility for extracting dihydroartemisinic acid from waste oil generated in artemisinin production

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Take 100KG of artemisinin production waste oil containing 6.5% dihydroartemisinic acid and pour it into the feeding port 4, turn on the stirring motor 3, and add the extraction solution containing alkaline substances from the liquid inlet 16 under the stirring rod 9 , the alkaline substance is one of sodium hydroxide, sodium bicarbonate, disodium bicarbonate, and potassium hydroxide, and the extraction solvent is one of water, methanol water, ethanol water, and acetone water, and the concentration is 20- 80%, the present embodiment adopts 2000L of 50% methanol aqueous solution containing 10% sodium hydroxide; after mixing, keep stirring at room temperature for 8 hours, turn off the stirring motor and let it stand for 4 hours; the obtained extract has obvious stratification, and the upper layer is about 1400L; Open the valve at the corresponding position of the supernatant discharge pipe 12 according to the liquid level of the supernatant, use the vacuum storage tank 19 t...

Embodiment 2

[0028]Take 10 kilograms of dihydroartemisinic acid crude product fluid paste with a content of about 30% and pour it from the feeding port 4, add 1000 ml of acetone solvent with a volume fraction of 30% from the liquid inlet 16, turn on the stirring motor 3 and stir for 30 minutes, then statically Place crystallization in 48 hours; open the valve after the crystallization is complete, control the crystallization liquid to flow into the three-legged centrifuge 11 and carry out filtration and centrifugation, open the valve of the liquid storage tank 10 and the feed liquid pump 23, and make the primary crystallization mother liquid return in the extraction tank 26 and carry out Repeat the extraction, repeat the above steps 4 times, and combine to obtain 3.65 kg of off-white crystals, the content of dihydroartemisinic acid is 78% after testing; pour 3.65 kg of off-white crystals from the feeding port 4, and add the concentration from the liquid inlet 16 It is 36.5L of 50% acetone s...

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Abstract

The invention discloses a facility for extracting dihydroartemisinic acid from waste oil generated in artemisinin production. The facility comprises an extraction pot, a stirring device is arranged inthe extraction pot; the upper part of the body of the extraction pot is communicated with a cooling part; the body of the extraction pot is externally provided with an interlayer; the interlayer is communicated with a cooling water pipe, a steam inlet pipe, and a steam cooling water discharge pipe; the body of the extraction pot is provided with a plurality of material outlets at different heights; the material outlets are connected with a crude filtering device; the body of the extraction pot is communicated with the material inlet of a centrifuge through a bottom discharge pipe; the bottomdischarge pipe is also provided with a branch pipe that is communicated with a liquid storage tank; the discharge pipe of the centrifuge is communicated with the crude filtering device; and the crudefiltering device is communicated with a vacuum storage tank, a liquid pump, a fine filtering device, and a normal pressure storage tank through pipelines. The purity of dihydroartemisinic acid is high, after impurities and oil are removed by the facility. The recovery rate of waste oil can reach 96.2%.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and in particular relates to a device for extracting dihydroartemisinic acid from artemisinin production waste oil. Background technique [0002] Artemisinin is a new type of antimalarial drug discovered by Mr. Tu Youyou, a famous Chinese pharmacist and winner of the 2015 Nobel Prize in Medicine, which has the advantages of "high efficiency, quick action, and low toxicity". There are special effects. From 1973 when artemisinin was discovered to 2018, artemisinin and artemisinin derivatives have developed into a large industry with an annual output value of 1.5 billion US dollars in the past few decades, and the price of artemisinin in 2012 After reaching the peak price of 5,800 yuan per kilogram in recent years, it fell all the way to 950 yuan per kilogram in 2016. From 2016 to 2018, the price of artemisinin has been in the price range of 950-1200 yuan per kilogram, and most artemisinin manuf...

Claims

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Application Information

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IPC IPC(8): C07C57/26C07C51/48C07C51/47
CPCC07C51/48C07C51/47C07C2602/28C07C57/26
Inventor 彭国平廖书桥欧阳斌
Owner HUNAN AGRICULTURAL UNIV
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