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Upper gastrointestinal flora improving agent

A digestive tract and improving agent technology, applied in the field of microbiology, can solve the problems of gastrointestinal flora imbalance, recurrent reinfection, increase, etc., and achieve the effect of inhibiting decomposition, excellent proliferation inhibition, and high extraction rate

Inactive Publication Date: 2019-08-20
嘉兴市爵拓科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, Western medicine antibiotic therapy can easily cause gastrointestinal flora imbalance, and a series of side effects such as recurrent infection after drug withdrawal, especially the rapid increase of drug-resistant strains, etc. are increasing day by day

Method used

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  • Upper gastrointestinal flora improving agent
  • Upper gastrointestinal flora improving agent
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation method of plant extract containing salidroside and tyrosol:

[0035] 1) Evenly mix ethylene glycol and homoserine with a molar ratio of 1:0.5 in water, heat and stir at 60°C until a transparent liquid is formed, and then place it at 40°C for 10 hours to obtain the extract, which has a water content of 40 %;

[0036] 2) According to the ratio of material to liquid 1:12 (g / mL), add the extraction solvent to the Rhodiola rosea powder, mix evenly, and then conduct ultrasonic extraction at a temperature of 45°C and an ultrasonic power of 40W for 20 minutes to obtain an extract, dilute, centrifuge, and The clear solution was diluted 4 times with water, and filtered through a 0.45 μm microfiltration membrane to obtain a plant extract containing salidroside and tyrosol.

Embodiment 2

[0038] Preparation method of plant extract containing salidroside and tyrosol:

[0039] 1) Evenly mix ethylene glycol and homoserine with a molar ratio of 1:0.8 in water, heat and stir at 90°C until a transparent liquid is formed, and then place it at 50°C for 15 hours to obtain the extract, which has a water content of 60 %;

[0040] 2) Add the extraction solvent to the Rhodiola rosea powder according to the ratio of material to liquid 1:13 (g / mL), mix well, and then conduct ultrasonic extraction at a temperature of 55°C and an ultrasonic power of 50W for 30 minutes to obtain the extract, dilute, centrifuge, and The clear solution was diluted 6 times with water, and filtered through a 0.45 μm microfiltration membrane to obtain a plant extract containing salidroside and tyrosol.

Embodiment 3

[0042] Preparation method of plant extract containing salidroside and tyrosol:

[0043] 1) Evenly mix ethylene glycol and homoserine with a molar ratio of 1:0.6 in water, heat and stir at 80°C until a transparent liquid is formed, and then place it at 50°C for 12 hours to obtain the extract, which has a water content of 40 -60%;

[0044] 2) According to the ratio of material to liquid 1:12.5 (g / mL), add the extraction solvent to the Rhodiola rosea powder, mix evenly, and then perform ultrasonic extraction at a temperature of 50°C and an ultrasonic power of 50W for 30 minutes to obtain the extract, dilute, centrifuge, and The clear liquid is diluted 5 times with water, and filtered through a 0.45 μm microfiltration membrane to obtain a plant extract containing salidroside and tyrosol.

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Abstract

The invention provides application of plant extracts containing salidroside and tyrosol to preparation of a medicine for resisting helicobacter pylori and an upper gastrointestinal flora improving agent including the plant extracts, and belongs to the technical field of microorganisms. The preparation method of the plant extracts comprises the following steps: adding an extraction solvent into plant powder; carrying out uniform mixing and ultrasonic extraction to obtain extracting solutions; diluting and centrifuging the extracting solutions; and filtering supernatant liquid through a micro-filtration membrane to obtain a final product. The improving agent is applied to helicobacter pylori-positive people; and improvement of the upper gastrointestinal flora means reduction of the helicobacter pylori in the upper gastrointestine. According to the upper gastrointestinal flora improving agent disclosed by the invention, extracting ratios of the salidroside and the tyrosol in the plant extracts are high, the urease activity can be inhibited in a high-selective manner, and the improving agent has the excellent survival inhibition effect and bacteria removal / discharging effects on the helicobacter pylori and can be applied to the medicine for resisting the helicobacter pylori; and moreover, the prepared improving agent can be used for inhibiting the survival and urease activity of the helicobacter pylori, can maintain the balance of microecology of stomachs, and can improve the upper gastrointestinal flora.

Description

technical field [0001] The invention belongs to the technical field of microorganisms, and in particular relates to an agent for improving bacterial flora in the upper digestive tract. Background technique [0002] The upper gastrointestinal tract consists of the oral cavity, pharynx, esophagus, stomach, and duodenum. Diseases of the upper gastrointestinal tract can seriously affect people's daily life and work. The primary pathogenic factor of upper gastrointestinal diseases is Helicobacter pylori. Helicobacter pylori is a microaerophilic, single-stage, blunt-ended helical curved bacterium that is Gram-negative and colonizes the host's stomach. It is one of the most common infectious pathogens in the world. After the human body is infected with Helicobacter pylori, there will be an imbalance between the invasion and defense factors of the digestive tract mucosa, so it is very easy to suffer from various upper gastrointestinal diseases. Helicobacter pylori infection has the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/41A61K36/45A61K36/638A61K31/7032A61K31/05A61P31/04
CPCA61K31/05A61K31/7032A61K36/41A61K36/45A61K36/638A61P31/04A61K2300/00
Inventor 吕淑伟杨志军郑宝华徐久龙
Owner 嘉兴市爵拓科技有限公司
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