A high-throughput analytical method for the determination of ultra-multi-target aroma components in e-cigarette liquid

A technology of e-cigarette liquid and aroma components, which is applied in the direction of analyzing materials, measuring devices, and material separation, etc., to achieve the effects of environmental friendliness, wide range, and less solvent consumption

Active Publication Date: 2021-10-15
ZHENGZHOU TOBACCO RES INST OF CNTC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the simultaneous determination of multiple flavor components in e-cigarette liquid by gas chromatography-tandem mass spectrometry (GC-MS / MS)

Method used

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  • A high-throughput analytical method for the determination of ultra-multi-target aroma components in e-cigarette liquid
  • A high-throughput analytical method for the determination of ultra-multi-target aroma components in e-cigarette liquid
  • A high-throughput analytical method for the determination of ultra-multi-target aroma components in e-cigarette liquid

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0044] It is weighing 1 g of electronic mobacterial samples in 15ml assiglement tube, adding 5 ml of phosphate buffer to adjust pH to 3; add 5 mL to extract solvent and internal standard working fluid, vortex at 2500 r / min 1 min; add 3 g chlorination Sodium, then centrifuged at 2500 R / min for 5 min, 6000 r / min for 5 min; Take 1 ml of the supernatant in 2 ml of centrifuge tube, and 200 mg of anhydrous sulfate is added, and then centrifuged at 2500 r / min for 1 min, 6000 r / min. 5 min; The supernatant was filtered through 0.22 μm organic phase filtration, GC-MS / MS analysis was performed.

[0045] The GC-MS / MS analysis conditions are as follows:

[0046] Gas chromatography: Columns: Elastic quartz capillary column, fixed phase 50% phenyl-methyl polysiloxane, specifications 60M × 0.25 mm × 0.25 μm, inlet end series preparation (5M × 0.25 mm) Input temperature: 290 ° C; injection volume: 0.8μL; injection mode: no shunt injection, no shunt time is 1min; carrier gas: helium, ...

example 2

[0065] Weigh 1 g of electronic mobacterial samples in 15ml assiglement tube, add a standard solution to add a level of 0.5 μg / g; add 5 ml of phosphate buffer to adjust the pH to 3; add 5 mL extraction solvent and The working fluid was laminated at 2500r / min for 1 min; 3 g of sodium chloride was added, then centrifuged at 2500 r / min for 1 min, 6000 r / min was centrifuged for 5 min; taking 1 mL of the supernatant in 2 ml of centrifuge tube, 200 mg of anhydrous magnesium sulfate It immediately centrifuged at 2500 r / min for 1 min, 6000 r / min was centrifuged for 5 min; GC-MS / MS analysis was carried out after 0.22 μm organic phase filtration; GC-MS / MS analysis conditions Reference Example 1.

[0066] According to the above operation, 5 parallel and day-to-day parallel tests were performed in the day, calculated the measurement results, as shown in Table 3, indicated in the day 3, and the precision of the day is 0.3 ~ 24.8%, respectively. 1.0 ~ 25.0%, 485 targets of the da...

example 3

[0076] With example 1, four different flavor of electronic cigarette smoke samples were detected, respectively, with fruit flavor, mango flavor, plant flavor, strawberry flavor. In the fruit flavor, the top 5 compounds are the highest level of content is ethyl maltol, propionate, 2-hexenol, isoprene, ethyl lactate; mango-flavored electronic humming solution In the highest content, the top 5 compounds are sequentially ethyl maltol, gamma-decyrithan, fragrant elinol, 2-hexenol, diphenyl ether; plant flavor electronic humming smoke solution, the top 5 The compound is subjected to meintone, menthol, 2-nonrene-1-alcohol, N, 2,3-trimethyl-2-isopropyl butylamide, citracetal; strawberry flavor, the highest content The top 5 compounds were cinnamic acid methyl esters, ethyl lactate, gamma-decyl ester, dihydrogenacid, 2-hexenol. The specific content is shown in Table 4 to Table 7.

[0077] Table 4 Composition of ambulatory ingredients of fruit flavor

[0078]

[0079]

[0080]

[0081...

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Abstract

The invention relates to an analysis method for high-throughput determination of super multi-target aroma components in electronic cigarette liquid, which belongs to the technical field of component detection of electronic cigarette liquid. After organic solvent extraction, salting out and layering, desiccant to remove water, combined with gas chromatography-tandem mass spectrometry technology to realize the simultaneous detection of 511 flavor components in e-cigarette liquid. The invention has the advantages of simple and fast operation, high flux, low cost, less solvent consumption, environmental friendliness, wide range of analyzable compounds, high accuracy, good precision, high sensitivity and good repeatability, etc. The need for rapid analysis and detection of aroma components in e-liquid.

Description

Technical field [0001] The present invention belongs to the technical field of electronic humming liquid flavor component detection, and more particularly to a gas chromatography-tandem mass spectrometry (GC-MS / MS) simultaneously determines the analysis method of 511 flavor components in electronic cigarette smoke liquid. Background technique [0002] Electronic humming solution is usually composed of an atomizing agent (glycerol and / or propylene glycol), water, nicotine, and flavoring of the oxygen. The content of fragrance components in the sooboxifier is no more than 10%, but is one of the most important factors that determine the quality of electronic cigarettes. At present, people have less research on the fragrance components in the electronic cigarette smoke, and the measurement method is mainly concentrated in gas chromatography material spectrometry (GC / MS). That is, after the pre-processing is completed, the full scan (SCAN) analysis is first retrieved by retrievi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/14
CPCG01N30/02G01N30/06G01N30/14G01N2030/045
Inventor 陈黎任宗灿赵嘉幸刘惠民谢复炜崔华鹏王晓瑜樊美娟刘绍锋余晶晶秦亚琼
Owner ZHENGZHOU TOBACCO RES INST OF CNTC
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