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Method for detecting surface defects of anti-inflammatory drug granules

A defect detection and drug particle technology, which is applied in optical testing defects/defects, measuring devices, image data processing, etc., can solve the problems of lack of particles, the influence of inspection accuracy fatigue and experience, foreign matter on the surface of drug particles, etc., to achieve simple detection. Effect

Inactive Publication Date: 2019-08-06
云南安宁化工厂有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] During the production process of pills and tablets, there will be adverse phenomena such as missing grains, half grains, and foreign matter on the surface of the pills
The flow of defective products into the market has a negative impact on the image of pharmaceutical companies. At present, manual observation is mainly used for detection. This method is affected by human supervisor factors, and the detection accuracy will be affected by human fatigue and experience.

Method used

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  • Method for detecting surface defects of anti-inflammatory drug granules
  • Method for detecting surface defects of anti-inflammatory drug granules
  • Method for detecting surface defects of anti-inflammatory drug granules

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0032] The first step is to obtain the image of the drug particles in the drug board, that is, to collect the image of the drug particles through a color camera;

[0033] The second step is to convert the image, that is, to convert the image of the drug particles collected in the first step into H 1 S 1 I 1 image;

[0034] The third step is image correction, that is, the I converted into the second step 1 In the image, set n=100 rectangular detection areas with height H=200 and width W=10 on the right edge of the medicine board, and obtain the point coordinate set (X(n), Y (n)), the point coordinate set is fitted into the right edge line by Hough transform, and the center point coordinates (2030, 1184) of the right edge of the medicine plate are obtained, according to the angle (-89°) of the right edge line and Center point coordinates (2030, 1184), correct the image with reference to the template position (angle (-85°) and center point coordinates (2010, 1181)), and gener...

specific Embodiment 2

[0039] The first step is to obtain the image of the drug particles in the drug board, that is, to collect the image of the drug particles through a color camera;

[0040] The second step is to convert the image, that is, to convert the image of the drug particles collected in the first step into H 1 S 1 I 1 image;

[0041] The third step is image correction, that is, the I converted into the second step 1In the image, set n=100 rectangular detection areas with height H=200 and width W=10 on the right edge of the medicine board, and obtain the point coordinate set (X(n), Y (n)), the point coordinate set is fitted into the right edge line by Hough transform, and the center point coordinates (2028, 1186) of the right edge of the medicine plate are obtained, according to the angle (-88°) of the right edge line and Center point coordinates (2028, 1186), correct the image with reference to the template position (angle (-85°) and center point coordinates (2010, 1181)), and genera...

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Abstract

The invention discloses a method for detecting surface defects of anti-inflammatory drug granules. The method comprises the following steps: step one, acquiring a drug granule image in a drug board; to be specific, collecting a drug granule image by a color camera; step two, converting the image; to be specific, converting the drug granule image collected in the step one into an H1S1I1 image; stepthree, carrying out image correction; to be specific, correcting an image by referring to a template position to generate a new image; step four, converting the new image; to be specific, convertingthe newly generated image in the step three into an H2S2I2 image; step five, screening drug granule defects; to be specific, screening a drug granule communication area in the S2 image in the step four; and step six, evaluating the drug granule quality; to be specific, carrying out hole filling in the drug granule communication area in the step five, carrying out subtraction with an original imageto obtain a foreign matter region, and carrying out comparison on the foreign matter region and an area threshold (A2Min, A2Max) to determine the quality of the drug granule. Therefore, the detectionbecomes simple, convenient and rapid.

Description

technical field [0001] The invention relates to the field of drug detection, in particular to a method for detecting surface defects of anti-inflammatory drug particles. Background technique [0002] There are many testing items for drug testing, including drug quality testing, drug composition testing, drug heavy metal testing, drug adverse reaction testing, drug tightness testing, biological drug testing, drug appearance testing, drug routine testing, drug physical and chemical testing, drug safety testing and Drug defect detection. [0003] During the production process of pills and tablets, there will be adverse phenomena such as missing grains, half grains, and foreign matter on the surface of the pills. The flow of defective products into the market has a negative impact on the image of pharmaceutical companies. At present, manual observation is mainly used for detection. This method is affected by human supervisor factors, and the detection accuracy will be affected ...

Claims

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Application Information

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IPC IPC(8): G01N21/88G06T7/00G06T7/136G06T7/187
CPCG01N21/8851G01N2021/8887G06T7/0004G06T7/136G06T7/187G06T2207/10024
Inventor 关帅孙志强于常青曾建江
Owner 云南安宁化工厂有限公司
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