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Method for determining the content of alkaloids, lignans and nucleosides in Radix isatidis or its preparations by one-measurement-multiple-evaluation method

A technology of lignans and alkaloids, applied in measuring devices, material separation, analysis of materials, etc., to achieve the effects of accurate control, strong practicability, and stable and uniform quality

Active Publication Date: 2022-07-05
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Abstract
  • Description
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Problems solved by technology

[0004] At present, there is no research report on the simultaneous determination of the content of alkaloids, nucleosides and lignans in Radix isatidis or its preparations by the one-test and multiple-evaluation method

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  • Method for determining the content of alkaloids, lignans and nucleosides in Radix isatidis or its preparations by one-measurement-multiple-evaluation method
  • Method for determining the content of alkaloids, lignans and nucleosides in Radix isatidis or its preparations by one-measurement-multiple-evaluation method
  • Method for determining the content of alkaloids, lignans and nucleosides in Radix isatidis or its preparations by one-measurement-multiple-evaluation method

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Embodiment Construction

[0035] The following is a further description of the present invention, rather than a limitation of the present invention.

[0036] Instruments and Reagents

[0037] Instrument: Agilent 1260 high performance liquid chromatograph (Agilent, USA); Thermo UltiMate 3000 high performance liquid chromatograph (Thermo Fisher, USA); Waters2695-2996 high performance liquid chromatograph (Waters, USA); Column Agilent ZORBAX-C18 (250mm×4.6mm, 5μm); Column Waters Xbridge-C 18 (250mm×4.6mm,5μm); Chromatographic column Phenomenex Kinetex-C 18 (250mm×4.6mm, 5μm); CPA 225D 1 / 100,000th balance (Shanghai Precision Instrument Co., Ltd.), KQ-600VDB dual-frequency CNC ultrasonic cleaner (Shanghai Shengke Instrument Co., Ltd.).

[0038] Reagents: (R,S)-Gao Yichun reference substance (batch number: 111753-201706, for content determination, with a purity of 100wt%, provided by China Institute for Food and Drug Control), cytidine (batch number: B20073, for content For determination, the purity is 98...

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Abstract

The invention discloses a method for determining the content of alkaloids, lignans and nucleosides in Radix isatidis or its preparation by adopting a one-measurement multi-evaluation method. , S)-Yichun is used as a reference to establish its relative correction factor with the lignan compound tetracycline B and the nucleoside compounds cytidine, uridine, guanosine, and adenosine, to achieve by measuring only The content of (R,S)-report Yichun of Radix Isatidis or its preparations, the content of the other 5 kinds of lignans and nucleosides with higher content was calculated by the correction factor, so as to be simple, quick, comprehensive and accurate. The multi-index quality evaluation of its preparation is helpful to ensure the quality of the product is controllable and the curative effect is stable, while saving the testing cost and time.

Description

Technical field: [0001] The invention relates to the technical field of Radix Isatidis detection, in particular to a method for determining the contents of alkaloids, lignans and nucleosides in Radix Isatidis or a preparation thereof by adopting a one-measurement multi-evaluation method. Background technique: [0002] Radix Isatidis is the dry root of the cruciferous plant Jiang Lan, and its main functions are clearing away heat and detoxifying, cooling blood and soothing throat. It is used for poisoning during warm epidemic, fever and sore throat, spots caused by warm poison, mumps, dandruff in the throat, large head plague, erysipelas, and carbuncle. Radix isatidis mainly contains lignans, alkaloids, nucleosides and other active ingredients. Lignans are a class of plant secondary metabolites formed by the oxidative polymerization of two molecules of phenylpropanoid derivatives. It has various pharmacological activities such as anti-virus, anti-inflammatory, anti-oxidatio...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 黄远董福越王德勤李淑如李楚源
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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