Planar metal micro-needle array and preparation method thereof

Abstract

The invention discloses a planar metal micro-needle array and a preparation method thereof, and belongs to the technical field of medical instruments and the field of machining. A large-size metal sheet is cut into small-sized metal sheets, a clamping tool composed of an upper metal cover plate and a lower metal cover plate is machined, a groove matched with the size of the small-sized metal sheets is formed in the inner side of the upper cover plate of the tool, and through holes are formed in the edges of the periphery of the cover plate; the metal sheet is placed in the groove, and fastenedthrough bolts; the geometrical shape and the size of the sheet-shaped micro-needle array are designed, and a plane micro-needle CAD model is constructed; according to a cutting wire feeding path of the CAD model, the sharp degree of needle tips is ensured by adopting an 8-shaped path during machining of the micro-needle tips, and a few materials are left on the two sides of a micro-needle array substrate to be not cut; and after the processing is finished, a tool is disassembled to clean the substrate, and unprocessed parts of the two sides of the micro-needle substrate are cut to obtain theplanar metal micro-needle array with a plurality of micro-needle bodies. The micro-needle array can be manufactured in a large scale through simple assembly, the cost is low, the efficiency is high, and the machining precision of the micro-needle tips can be guaranteed.

Description

Technical field [0001] The invention belongs to the technical field of medical equipment and the field of mechanical processing, and relates to a planar metal microneedle array and a preparation method thereof. Background technique [0002] Oral administration, injection administration and transdermal administration are currently the three most commonly used methods of administration, but oral administration needs to pass through tissues and organs such as the gastrointestinal tract and liver. Intestinal inactivation and liver "first pass" Some drugs are metabolized, and the absorption efficiency is greatly reduced; on the other hand, some drugs can cause adverse gastrointestinal irritation and other side effects, which limits the application range of oral administration, especially not suitable for protein, insulin and DNA types. Drug delivery. Although injection drug delivery technology overcomes the above shortcomings, penetrating a larger-sized ordinary needle into human tis...

AI Technical Summary

Problems solved by technology

At present, metal microneedle processing methods are quite rich, including chemical etching, ultraviolet lithography, micro-milling, laser cutting, electroplating, etc., but these processing methods have the disadvantages of low processing accuracy, low processing efficiency and high cost, and it is difficult to meet the requirements of mass production. Production requirements

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