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Blood coagulation detection chip and electrochemical sensor

A detection chip and coagulation technology, applied in the field of coagulation detection, can solve the problems of large size of detection instruments, poor light transmittance, affecting the accuracy of detection results, etc., and achieve the effects of rapid prognosis evaluation, high accuracy, and rapid drug efficacy monitoring

Active Publication Date: 2019-07-26
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor light transmission of complex samples such as blood, the accuracy of the test results is affected, and the detection instruments designed based on optical principles have the defects of large volume, difficulty in portability and miniaturization

Method used

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  • Blood coagulation detection chip and electrochemical sensor
  • Blood coagulation detection chip and electrochemical sensor
  • Blood coagulation detection chip and electrochemical sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] This embodiment provides a blood coagulation detection chip, and the surface of the blood coagulation detection chip forms the detection area 5 of the sample to be tested. Along the flow direction of the sample to be tested, the detection area 5 is divided into a first working area 51 , a transition area 53 and a second working area 52 connected in sequence. Such as figure 1 As shown, the coagulation detection chip includes a sample inlet 3 , a first detection channel 1 and a second detection channel 2 . Wherein, the sampling port 3 is provided at one end of the coagulation detection chip close to the first working area 51, the sampling port 3 is connected to the sampling channel 4, and the end of the sampling channel 4 away from the sampling port 3 forms two independent first communication channels. The first communication port is connected to the first detection channel 1, and the second communication port is connected to the second detection channel 2. After the sa...

Embodiment 2

[0093] This embodiment provides a blood coagulation detection chip, which differs from the blood coagulation detection chip provided in Example 1 in that:

[0094] The driving member 8 includes a hydrophilic part disposed in the first working area 51 and the second working area 52 , and a hydrophobic part disposed in the transitional area 53 . Since the first working area 51 is provided with a hydrophilic part, and the transition area 53 is provided with a hydrophobic part, when the blood sample flows from the first working area 51 to the transition area 53, the flow velocity becomes slow, thereby limiting the flow of the blood sample. When the blood sample flows from the transition area 53 to the second working area 52, since the second working area 52 is provided with a hydrophilic part, the blood sample flows from the hydrophobic area to the hydrophilic area, and the flow velocity increases, and finally the blood sample flows through the first The speed V of the working are...

Embodiment 3

[0096] This embodiment provides a blood coagulation detection chip, which differs from the blood coagulation detection chip provided in Example 1 in that:

[0097] Such as Figure 9 As shown, the driver 8 includes a required number of flow limiting components located in the first working area 51 , and a required number of microhole components located in the transitional area 53 and the second working area 52 . Wherein, the restrictor assembly includes a first restrictor 81 and a second restrictor 82, the first restrictor 81 and the second restrictor 82 have a first opening and a second opening along the direction of blood flow, the first The diameter of the opening is larger than the diameter of the second opening. The microhole assembly includes a required number of microholes 83 opened in the transition region 53 and the second working region 52 . When the blood sample flows into the flow limiting component, it flows in through the first opening, and then flows out through...

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Abstract

The invention discloses an electrochemical detection chip, which comprises a first detection channel and a second detection channel, wherein a sample to be detected flows through a detection area of the blood coagulation detection chip. The detection area is divided into a first working area, a transition area and a second working area which are connected in sequence, wherein the first working area corresponds to the first detection channel to form a pre-reaction area, and the second working area corresponds to the first detection channel and the second detection channel to form a first reaction area and a second reaction area respectively; and a driving piece for driving the sample to be detected to flow from the first working area to the second working area is arranged on the detection area. The electrochemical detection chip can realize the integrated detection of PT and APTT, and has accurate result, high sensitivity and good repeatability. The invention discloses an electrochemical sensor, which comprises the electrochemical detection chip and can realize rapid and sensitive integrated detection of PT and APTT.

Description

technical field [0001] The invention relates to the technical field of blood coagulation detection, in particular to a blood coagulation detection chip and an electrochemical sensor. Background technique [0002] Whether the blood coagulation function is normal or not is related to the physiological health of the human body, and the evaluation experiment of blood coagulation function is of great significance to the diagnosis, treatment and prognosis of various diseases. The blood coagulation process is complex and the detection indicators are diverse, which are mainly divided into extrinsic coagulation pathway and intrinsic coagulation pathway. Coagulation time is an important indicator to measure the state of coagulation, and it is of great significance for judging the pathological changes of the body's hemostasis and coagulation system, and for preoperative screening of coagulation diseases. Among them, prothrombin time (PT, Prothrombin Time) is an important indicator of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327G01N27/416B01L3/00
CPCB01L3/5027G01N27/3272G01N27/416
Inventor 周连群郑安然张威郭振李超李金泽
Owner SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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