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Applications of salvianolic acid A in preventing and treating muscular atrophy, myopathy and musculoskeletal complications

A technology of muscle atrophy and salvianolic acid, which is applied in the field of medicine to achieve safe and reliable drug effects

Active Publication Date: 2019-07-23
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the direct or indirect therapeutic effect of salvianolic acid A on muscle atrophy and improvement of muscle atrophy caused by diabetes and related diseases, genetics, muscular dystrophy and neurological dysfunction, myopathy, and musculoskeletal complications.

Method used

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  • Applications of salvianolic acid A in preventing and treating muscular atrophy, myopathy and musculoskeletal complications
  • Applications of salvianolic acid A in preventing and treating muscular atrophy, myopathy and musculoskeletal complications
  • Applications of salvianolic acid A in preventing and treating muscular atrophy, myopathy and musculoskeletal complications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: Establishment and administration of diabetic mouse model

[0035] Experimental principle

[0036] KKay mice are a mildly obese type 2 diabetes model, which were crossed with C57BL / 6J mice and inbred. The inbred KK mouse is a typical animal model of polygenic diabetes, which exhibits typical characteristics of type 2 diabetes, and diabetic complications may appear in the late stage.

[0037] experimental method

[0038] Male KKay mice, weighing 17-20g, were fed with high-sugar and high-fat diet, without water restriction. C57BL / 6J mice of the same age were used as a normal control group, weighing 17-20 g, fed with complete nutritional feed, without water restriction. Roche blood glucose meter was used to measure the fasting blood glucose value, and blood was taken from the tip of the tail to measure random blood glucose ≥11.1mmol / L) as the model group.

[0039] Sixty male KKay mice with blood glucose ≥11.1mmol / L were randomly divided into 3 groups, mode...

Embodiment 2

[0042] Example 2: Effect of salvianolic acid A on general conditions such as blood sugar / blood lipid / food intake / water intake / body weight in diabetic mice

[0043] animal food intake

[0044] Experimental method: See Example 1 for animal models. The water intake of animals is an important index reflecting the energy metabolism of animals, and can evaluate the situation of animals' intake and utilization of calories. Animal food and water intake. On the 8th week of administration, the 24-h food intake and water intake of the mice were recorded, and the difference between the animal's initial food and water volume and the remaining food and water volume after 24 hours was taken as the 24-h food and water intake. Accurately weigh the feed before feeding, observe after 24 hours, and weigh the remaining feed. Add feed each time to meet the animal's food intake, and there is a little surplus.

[0045] Experimental results: In this experiment, the amount of food and water intake ...

Embodiment 3

[0055] Example 3: Effect of salvianolic acid A on the contractility of skeletal muscle caused by diabetes

[0056] Experimental principle

[0057] The purpose of testing the contractility of animal skeletal muscles is to evaluate the influence of various factors on the strength of animal limbs, and also to measure the aging, nerve damage, bone damage, and muscle damage of animals. The determination method is simple in operation, convenient in use, clear in index and strong in specificity, and can measure the real and objective grasping force of animals.

[0058] experimental method

[0059] Animal grip: measure the grip of animal limbs. The grasping force of the fore and hind limbs was measured using a grasping force meter. Animal muscle strength was measured with a grip tester, and the specific operation was referred to the manufacturer's instructions (Beijing zhishuduobao biologicaltechnology, China). Briefly, grasp the tail of the rat, let the animal's forelimbs, or hin...

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Abstract

The invention relates to a novel pharmacological action of a traditional Chinese medicine monomer salvianolic acid A, and applications of the salvianolic acid A in preparing products for preventing, relieving and / or treating including muscular atrophy, myopathy, musculoskeletal complications and complications thereof caused by various reasons including diabetes, heredity, muscular dystrophy and neurological dysfunction. The salvianolic acid A has the advantages that: the salvianolic acid A has the effects of delaying and treating muscular atrophy caused by various reasons and diabetes, increasing skeletal muscle strength, improving skeletal muscle tissue microcirculation, increasing skeletal muscle weight, and improving pathological injury of skeletal muscle tissues. The salvianolic acid Ais a monomer compound extracted from danshen roots, has low toxicity and wide raw material resources, has good application and development prospects, and can be used for preventing, relieving and treating muscular atrophy, diabetic myopathy, diabetic muscular atrophy, diabetic musculoskeletal complications and complications thereof caused by various reasons.

Description

technical field [0001] The present invention relates to the preparation of salvianolic acid A in the prevention, alleviation and / or treatment of various causes, including muscle atrophy, myopathy, musculoskeletal complications and its related diseases, genetics, muscular dystrophy and neurological dysfunction. The application of the complication product medicine belongs to the technical field of medicine. Background technique [0002] Muscle wasting is a disease state that occurs primarily in a variety of chronic diseases and during aging. Can seriously affect quality of life and, in severe cases, lead to death. Skeletal muscle atrophy refers to a group of diseases that damage human muscles such as rhabdomyotrophy, muscle fiber thinning or even disappearance, muscle volume reduction, and muscle contractility impairment. The pathophysiological process is progressive skeletal muscle atrophy, loss of muscle protein, and death of muscle cells or tissues. The etiology mainly i...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61P21/00A61P19/00A61P3/10A61P3/06A61P25/02
CPCA61K31/216A61P21/00A61P19/00A61P3/10A61P3/06A61P25/02
Inventor 杜冠华杨秀颖张莉强桂芬贾伟华侯碧玉陈熙殷琳
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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