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Application of belinostat in preparation of medicine for relieving and/or treating cerebral arterial thrombosis

A technology of ischemic stroke and belistat, which is applied in the field of medicine, can solve the problem that the direct or indirect therapeutic effect of belistat has not been reported, and achieve safe and reliable drug effects

Pending Publication Date: 2022-04-12
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the direct or indirect therapeutic effect of belistat on stroke.

Method used

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  • Application of belinostat in preparation of medicine for relieving and/or treating cerebral arterial thrombosis
  • Application of belinostat in preparation of medicine for relieving and/or treating cerebral arterial thrombosis
  • Application of belinostat in preparation of medicine for relieving and/or treating cerebral arterial thrombosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: The protective effect of belistat on rats with acute cerebral ischemia-reperfusion 1.1 Establishment and administration of experimental cerebral ischemia-reperfusion model

[0035] Experimental principle

[0036] Select Wistar rats, and after 3% isoflurane anesthesia, insert a embedment thread from the external carotid artery, through the internal carotid artery to the anterior cerebral artery, and mechanically block the blood supply at the origin of the middle cerebral artery. After blocking for 1.5 hours, the thread plug was pulled out, and the model of middle cerebral artery ischemia-reperfusion (MCAO / R) was established.

[0037] experimental method

[0038] Male Wistar rats, weighing 280-320g, were fed adaptively for 3 days to establish the MCAO / R model, and the animals were divided into normal control group, model group, belistat low-dose group (10mg / kg), middle-dose group (30mg / kg) and high dose group (50mg / kg). The normal control group was treated ...

Embodiment 2

[0059] Example 2: Bellinostat promotes neurological recovery in rats with cerebral ischemia-reperfusion

[0060] 2.1 Establishment of MCAO / R rat model and drug administration

[0061] Experimental principle

[0062] Select Wistar rats, and after 3% isoflurane anesthesia, insert a embedment thread from the external carotid artery, through the internal carotid artery to the anterior cerebral artery, and mechanically block the blood supply at the origin of the middle cerebral artery. After blocking for 1.5 hours, the thread plug was pulled out, and the model of middle cerebral artery ischemia-reperfusion (MCAO / R) was established.

[0063] experimental method

[0064] Male Wistar rats, weighing 280-320g, were fed adaptively for 3 days to establish the MCAO / R model, and the animals were divided into normal control group, model group, belistat low-dose group (10mg / kg), middle-dose group (30mg / kg) and high dose group (50mg / kg). The normal control group was treated the same as th...

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Abstract

The invention belongs to the technical field of medicines, and particularly discloses application of belinostat in preparation of a medicine for relieving and / or treating cerebral arterial thrombosis. In a rat cerebral ischemia reperfusion model, belinostat shows a good treatment effect, and can effectively prevent and treat pathological changes and progression of diseases.

Description

technical field [0001] The invention relates to the application of belistat in the preparation of medicaments for alleviating and / or treating ischemic stroke, and belongs to the technical field of medicine. Background technique [0002] Stroke is an acute onset cerebral blood circulation disorder. It is an acute cerebral blood circulation disorder caused by stenosis, occlusion or rupture of intracerebral arteries induced by various factors. It is clinically divided into ischemic stroke. and hemorrhagic stroke, among which ischemic stroke accounts for 80% of stroke. Stroke is a kind of refractory disease that seriously endangers human health and life, and has the characteristics of high morbidity, disability and mortality. Epidemiological data show that stroke has become the second most common cause of death in the world, and cardiovascular disease has become the first cause of death in my country. Therefore, the treatment and prognosis of stroke is a focus of current stroke...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/18A61K45/06A61P9/10
Inventor 杜冠华李莉杨冉刘德培陈厚早申艳佳陈渺杨海光
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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