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Compositions comprising dehydroepiandrosterone or its sulfate ester, levocarnitine, acetyl levocarnitine or their pharmaceutically acceptable salts and applications thereof

A technology of acetyl-L-carnitine meter and dehydroepiandrosterone, which is applied in the field of improving men

Active Publication Date: 2021-05-18
北京华睿鼎信科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The inventor unexpectedly found that levocarnitine, acetyl-levocarnitine and dehydroepiandrosterone have an unexpected synergistic effect in the treatment of male oligospermia and weak sperm and sperm deformity, and the composition has a safe and effective effect for long-term use. Features, in the prior art, there is no report about the application of levocarnitine, acetyl levocarnitine and DHEA composition in the treatment of oligoasthenospermia

Method used

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  • Compositions comprising dehydroepiandrosterone or its sulfate ester, levocarnitine, acetyl levocarnitine or their pharmaceutically acceptable salts and applications thereof
  • Compositions comprising dehydroepiandrosterone or its sulfate ester, levocarnitine, acetyl levocarnitine or their pharmaceutically acceptable salts and applications thereof
  • Compositions comprising dehydroepiandrosterone or its sulfate ester, levocarnitine, acetyl levocarnitine or their pharmaceutically acceptable salts and applications thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] The preparation of embodiment 1 levocarnitine, acetyl levocarnitine and dehydroepiandrosterone dry suspension (1000 bags of prescriptions)

[0025] L-carnitine 1000g Acetyl L-carnitine 500g DHEA 50g sucrose 2000g Sucralose 100g sodium benzoate 50g Strawberry Spice 10g xanthan gum 50g colloidal silica 20g

[0026] Take the raw and auxiliary materials, pulverize them, pass through a 200-mesh sieve respectively, dry them in an appropriate way, and set aside; weigh the raw and auxiliary materials according to the prescription amount, and use physical mixing method to directly mix them evenly. The process should be as fast as possible to minimize the entry of water; mix evenly The final powder is evenly put into aluminized film bag, and it is ready.

Embodiment 2

[0027] Preparation of Example 2 Levocarnitine Fumarate, Acetyl Levocarnitine and DHEA Granules (1000 Bags of Prescription)

[0028]

[0029] Pass the bulk drug through an 80-mesh sieve and set aside. The sucrose and gum arabic are pulverized in a high-speed multifunctional pulverizer, and passed through a 60-mesh sieve for later use, and other auxiliary materials are respectively passed through a 60-mesh sieve for later use. Weigh the prescribed amount of hydroxypropyl cellulose, add an appropriate amount of purified water to dissolve it, stir evenly, and set aside. Weigh sucrose, dextrin, gum tragacanth, gum arabic, levocarnitine fumarate, acetyl levocarnitine and DHEA in the wet granulator and stir evenly, then add the above The prepared adhesive is stirred evenly to make a soft material. The above-mentioned soft material is granulated in a oscillating granulator (40 mesh sieve). The above granules were dried in a fluidized bed at 60°C until the water content was less ...

Embodiment 3

[0030] The preparation of embodiment 3 levocarnitine, acetyl levocarnitine fumarate and dehydroepiandrosterone oral liquid (1000 prescriptions)

[0031]

[0032] The sodium saccharin, sodium benzoate, DL-malic acid, levocarnitine, acetyl levocarnitine fumarate and dehydroepiandrosterone were added to 80% of the total volume of purified water and stirred to dissolve. Add purified water to full volume. Stir evenly and filter, fill the obtained filtrate into soda-lime glass control oral liquid bottles, cap it, and sterilize it by autoclaving at 105°C for 30 minutes to obtain the product.

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Abstract

The present invention describes a synergistic composition and its use in the preparation of medicines or dietary supplements for improving male oligospermia, weak sperm, and reducing sperm deformity. The composition comprises dehydroepiandrosterone (DHEA) or dehydroepiandrosterone sulfate (DHEAS), levocarnitine or a pharmaceutically acceptable salt thereof, acetyl levocarnitine or a pharmaceutically acceptable salt thereof, compared to The existing technology is safer and more effective, can significantly improve semen concentration and sperm motility, and reduce sperm deformity.

Description

technical field [0001] The present invention relates to improving male oligospermia, weak sperm, increasing sperm concentration and sperm motility composition and application thereof, particularly relates to a kind of containing dehydroepiandrosterone (DHEA) or dehydroepiandrosterone sulfate (DHEAS), left The composition of carnitine or its pharmaceutically acceptable salt, acetyl-levocarnitine or its pharmaceutically acceptable salt and its application in improving male oligospermia and weak sperm, increasing sperm concentration and motility, and reducing sperm deformity. Background technique [0002] In recent years, with the development of society, the pressure of life has increased, the living environment has deteriorated, the pace of life has accelerated, and many unreasonable phenomena have appeared in the structure of life and diet, resulting in an obvious upward trend in infertility among couples of childbearing age. Factors account for about 35%-50% of infertility. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/5685A61K31/205A61P15/08A23L33/10
CPCA23V2002/00A61K31/205A61K31/5685A23L33/10A61P15/08A61K2300/00A23V2200/30
Inventor 常珍况斌张旭吕宁
Owner 北京华睿鼎信科技有限公司
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