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Drug-loaded balloon and preparation method thereof

A balloon and drug-loading technology, which is applied in medical science, balloon catheters, surgery, etc., can solve the problems of insufficient gene quantity, difficulty in exerting curative effect, easy loss, etc., and achieve the effect of avoiding excessive loss of genes

Active Publication Date: 2019-07-05
LIFETECH SCIENTIFIC (SHENZHEN) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Someone prepared a gene coating on the surface of the balloon, but during the delivery of the balloon in the body, due to the impact of the blood flow, the genes in the gene coating were easily lost, resulting in insufficient amount of genes carried on the balloon, or the genes were difficult to obtain. Released from the balloon to the lesion, making it difficult to exert therapeutic effect

Method used

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  • Drug-loaded balloon and preparation method thereof
  • Drug-loaded balloon and preparation method thereof
  • Drug-loaded balloon and preparation method thereof

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preparation example Construction

[0042] The preparation method of the drug-loaded balloon of one embodiment, comprises the following steps:

[0043] S110: A balloon is provided, and a drug-loaded layer is prepared on the outer surface of the balloon, and the drug-loaded layer contains a gene.

[0044] The balloon can be a round balloon, a cylindrical balloon or a balloon of other shapes.

[0045] The drug-loaded layer contains genes and gene carriers. The types and proportions of the gene and the matrix carrier are the same as above, and will not be repeated here.

[0046] Preferably, the drug-loaded layer also contains a stabilizer, and the types and proportions of the stabilizer are the same as above, and will not be repeated here.

[0047] Mix the gene, the gene carrier and the stabilizer evenly to prepare the first coating solution, apply the first coating solution on the outer surface of the balloon by spraying, dipping, dripping and other coating methods, and dry it on the balloon The outer surface f...

Embodiment 1

[0066] (1) Place the balloon in the plasma transmitter for surface treatment. Treatment conditions: power 500W, time 30min, atmosphere: mixed atmosphere of argon and oxygen, the flow rates of argon and oxygen are both 75sccm;

[0067] (2) Use RNase-free H 2 The has-miR-1298-5p mimic gene (purchased from Guangzhou Ruibo Biotechnology Co., Ltd., specification 5nmol) was dissolved in O to prepare a 200nM gene solution. Poloxamer P188 was treated with sterile ddH 2 O was configured as a 5mg / mL gene carrier solution. The above gene solution and gene carrier solution were mixed at a volume ratio of 8:2 to prepare the first coating solution. Each 100μL of the first coating solution contains 16×10 -3 nmol of has-miR-1298-5p mimic gene;

[0068] (3) Take 200 μL of the first coating solution with a syringe, slowly drop-coat it on the surface of the balloon, and repeatedly drop-coat it after drying until all the first coating solution is used up, and form a drug-loaded layer on the ...

Embodiment 2

[0072] (1) Place the balloon in the plasma transmitter for processing. Treatment conditions: power 700W, time 10min, atmosphere: mixed atmosphere of argon and oxygen, the flow rates of argon and oxygen are both 75sccm;

[0073] (2) with sterilized ddH 2 O dissolved the miR-21antagomir gene (purchased from Guangzhou Ruibo Biotechnology Co., Ltd., specification 0.5nmol), and prepared a 10nM gene solution. Gum Arabic and Tween were mixed at a ratio of 8:2 (mass ratio), and a gene carrier solution with a total concentration of 1 mg / mL was prepared with ethanol with a volume fraction of 20%. The above gene solution and gene carrier solution were mixed at a volume ratio of 5:5 to prepare the first coating solution. Each 100μL of the first coating solution contains 0.5×10 -3 nmol of miR-21antagomir gene;

[0074] (3) Use a syringe to take 500 μL of the first coating solution, slowly drop-coat it on the surface of the balloon, and repeatedly drop-coat it after drying until the fir...

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Abstract

The invention relates to a drug-loaded balloon. The drug-loaded balloon comprises a balloon, as well as a drug-loading layer and a protective layer which are sequentially stacked on the outer surfaceof the balloon; the drug-loading layer contains genes, and is covered with the protective layer; and the material of the protective layer is at least one selected from polyvinyl alcohol, polyvinylpyrrolidone, chitosan, hydroxypropyl-beta-cyclodextrin, hydroxyethyl cellulose, sodium carboxymethylcellulose, dextran, gum arabic, sodium alginate, collagen, soybean protein and polyethylene glycol stearate. The protective layer is capable of relatively well protecting the drug-loading layer, thereby avoiding excessive loss of the genes during delivery; moreover, the material of the protective layeris at least one selected from the aforesaid substances, so that, the protective layer can rapidly dissolve or fall off when the drug-loaded balloon expand upon arrival of the drug-loaded balloon at alesion site, thereby allowing rapid release of the genes.

Description

technical field [0001] The invention relates to the field of interventional medical devices, in particular to a drug-loaded balloon and a preparation method thereof. Background technique [0002] Compared with traditional surgical operations, interventional medical devices have the advantages of less bleeding, less trauma, fewer complications, safety and reliability, faster postoperative recovery and lower costs. Therefore, they have achieved rapid development in recent years. Since the first clinical application of balloon catheters for dilation therapy in 1974, Percutaneous Transluminal Angioplasty (PTA) has been widely used in the clinical treatment of various vascular occlusions and stenosis lesions, especially in arterial It plays a large role in the treatment of sclerosing strictures and occlusions. However, the incidence of restenosis after PTA is as high as 30-50%, which has become an obstacle to the development of PTA. [0003] The emergence of bare metal stents h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/16A61M25/00
CPCA61L31/10A61L31/16A61M25/10A61M25/0045A61L2420/08A61L2300/258A61M2025/105
Inventor 宋精忠龙汉
Owner LIFETECH SCIENTIFIC (SHENZHEN) CO LTD
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