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Preparation method of low-adhesion wound dressing

A wound dressing and low-adhesion technology, applied in medical science, absorbent pads, textiles and papermaking, etc., can solve the problems of difficult control of the thickness of the gel layer, restricting development, and easy detachment of the gel layer to achieve excellent anti-adhesion Effect, avoid secondary trauma, long-lasting effect of adhesion effect

Inactive Publication Date: 2019-07-05
ZHONGYUAN ENGINEERING COLLEGE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The methods for hydrogel deposition on the surface of cellulose materials mainly include dip coating method, film coating method, spin coating method, etc. At this time, the binding force between cellulose material and gel is determined by the physical force between them. Weak physical force makes it difficult to fix the gel on the surface of the material, the gel layer is easy to fall off and affects its use, and the thickness of the gel layer is difficult to control, which also restricts its development to a certain extent

Method used

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  • Preparation method of low-adhesion wound dressing
  • Preparation method of low-adhesion wound dressing
  • Preparation method of low-adhesion wound dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A preparation method of low-adhesion wound dressing, the specific steps are:

[0030] (1) Dissolve 6 mL of triethylamine (4.38 g) and 1 g of 4-dimethylaminopyridine in 100 mL of dry tetrahydrofuran successively, immerse 2 g of cotton fabric in the above solution at a bath ratio of 1:50, and control the temperature of the solution At 0-5°C, slowly add 4.58mL of 2-bromoisobutyryl bromide (8.52g) dropwise, react for 2 hours, then raise the temperature to 25°C, continue the reaction for 12 hours, and wash with tetrahydrofuran, ethanol and deionized water by ultrasonic oscillation for 15 minutes. Vacuum drying at 60° C. for 12 hours to obtain a cotton fabric macromolecular initiator.

[0031] (2) Take 90 mL of ethanol-water mixed solution with a volume ratio of 1:1, add 22.4 mg of copper bromide (0.10 mmol), 68 μL of pentamethyldiethylenetriamine (0.32 mmol) and 5.0 g of N-isopropyl Acrylamide (44.25 mmol), and then add 2 g of the above cotton fabric macroinitiator at a liq...

Embodiment 2

[0033] A preparation method of low-adhesion wound dressing, the specific steps are:

[0034] (1) Dissolve 6 mL of triethylamine (4.38 g) and 1 g of 4-dimethylaminopyridine in 100 mL of dry tetrahydrofuran successively, immerse 2 g of cotton fabric in the above solution at a bath ratio of 1:50, and control the temperature of the solution At 0-5°C, slowly add 4.58mL of 2-bromoisobutyryl bromide (8.52g) dropwise, react for 2 hours, then raise the temperature to 25°C, continue the reaction for 24 hours, and wash with tetrahydrofuran, ethanol and deionized water for 15 minutes by ultrasonic oscillation. Vacuum drying at 60°C for 24 hours to obtain a cotton fabric macromolecular initiator.

[0035](2) Take 90 mL of ethanol-water mixed solution with a volume ratio of 1:0.5, add 22.4 mg of copper bromide (0.10 mmol), 68 μL of pentamethyldiethylenetriamine (0.32 mmol) and 10.0 g of N-isopropyl Acrylamide (88.50 mmol), and then add 2 g of the above cotton fabric macroinitiator at a bat...

Embodiment 3

[0037] A preparation method of low-adhesion wound dressing, the specific steps are:

[0038] (1) Dissolve 9 mL of triethylamine (6.57 g) and 1.5 g of 4-dimethylaminopyridine in 100 mL of dry tetrahydrofuran successively, immerse 2 g of cotton fabric in the above solution at a bath ratio of 1:50, and control the temperature of the solution At 0-5°C, slowly add 4.58mL of 2-bromoisobutyryl bromide (8.52g) dropwise, react for 2 hours, then raise the temperature to 25°C, continue the reaction for 24 hours, and wash with tetrahydrofuran, ethanol and deionized water for 15 minutes by ultrasonic oscillation. Vacuum drying at 60° C. for 12 hours to obtain a cotton fabric macromolecular initiator.

[0039] (2) Take 90 mL of ethanol-water mixed solution with a volume ratio of 1:1.5, add 22.4 mg of copper bromide (0.10 mmol), 68 μL of pentamethyldiethylenetriamine (0.32 mmol) and 15.0 g of N-isopropyl Acrylamide (132.74mmol), and then add 2 g of the above cotton fabric macroinitiator at ...

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Abstract

The invention provides a preparation method of a low-adhesion wound dressing. The preparation method includes the steps of firstly, introducing 2-bromoisobutyl acyl bromide serving as a modifier to the surface of a cellulose material by the aid of a surface-initiated electron transfer activated regenerated catalyst atom transfer radical polymerization technique to prepare a cellulose-based macro-initiator; secondly, controllably building a gel-like molecular brush structure at the initiation locus of the surface of the cellulose material by N-isopropylacrylamide in a nitrogen environment, andperforming washing and drying to prepare the low-adhesion wound dressing. The prepared wound dressing has the advantages that gel molecules and the cellulose material are firmly combined in a covalentbond form to prepare the wound dressing, the wound dressing has excellent low-adhesion performance, secondary trauma caused by the adhesion between new granulation tissue and a traditional gauze dressing is avoided, a new idea is provided for the preparation of low-adhesion wound dressing, and the low-adhesion wound dressing is promising application prospect and market prospect.

Description

technical field [0001] The invention relates to the field of functional wound dressings, in particular to a preparation method for low-adhesion wound dressings. Background technique [0002] In recent years, with the continuous increase of production activities, the incidence of accidents such as burns has shown a trend of increasing year by year. At the same time, chronic wound diseases, such as diabetic foot ulcers, venous lower extremity ulcers, and bedsores, are also increasing significantly due to the aging of the global population, the rising prevalence of diabetes, and the significant increase in obesity. These traumas cause great pain to patients and seriously affect their quality of life. The healing of skin wounds is a complex process that involves the interaction of different tissues and cells. When the skin is injured, improper care can affect the healing effect and even leave scars. Therefore, it is necessary to choose a suitable dressing to cover the wound t...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/40A61L15/42D06M14/04
CPCA61L15/28A61L15/40A61L15/42D06M14/04C08L1/02
Inventor 欧康康周金利刘宏臣杜海娟汪青于伟杰肖培韩倩迪
Owner ZHONGYUAN ENGINEERING COLLEGE
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