A kind of preparation method of tilmicosin preparation

Abstract

The invention discloses a preparation method of a tilmicosin preparation, which comprises the following process steps: taking polyethylene glycol 6000 as a carrier, adding an anionic surfactant with a mass of 1 to 3% of the carrier, and heating in a constant temperature water bath at 60°C Make it all melt, then add the tilmicosin raw material drug while stirring until it is completely melted, the drug-loading ratio by mass is 1:2, then quickly pour it into a pre-cooled stainless steel container, and place it in a -20°C refrigerator in turn Solidify, dry in a drying oven at 35-40°C, and finally grind and pass through an 80-mesh sieve to obtain the finished product. The invention solves the problems of the existing tilmicosin preparations being insoluble in water, bitter in taste and low in bioavailability, and adopts solid dispersion technology to prepare the tilmicosin preparation capable of masking the bitter taste, soluble in water and high in bioavailability , it is convenient for drinking water to administer medicines, and can treat diseases in time, thereby bringing greater convenience and benefits to the breeding industry.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a preparation method of a tilmicosin preparation. Background technique [0002] Tilmicosin is a new type of macrolide antibiotics semi-synthesized from tylosin for livestock and poultry. It has good inhibitory effect on Gram-positive bacteria and some Gram-negative bacteria, mycoplasma, spirochetes, etc. , It has stronger antibacterial activity than tylosin against Actinomyces pleuropneumoniae and Pasteurella, and has no cross-resistance with commonly used clinical antibiotics. Clinically, it is mainly used for animal respiratory diseases and mastitis of lactating animals, especially in the treatment of porcine respiratory syndrome and porcine reproductive and respiratory syndrome. However, tilmicosin has a certain degree of irritation, and tilmicosin is mainly administered by oral administration and subcutaneous injection, especially for pigs, which limits its clinical application in...

AI Technical Summary

Problems solved by technology

However, tilmicosin targets alveolar macrophages, which itself has the effect of targeted therapy, and for some acute diseases, sustained-release preparations cannot play a role in timely treatment. Most of the techniques require the addition of organic reagents, and the dosage Larger, higher cost, and sometimes difficult to remove, polluting the environment. At present, these new preparation technologies have not been applied in actual production

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