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Aftertreatment technology of hydantion serialization preparation of glycine

A technology of glycine and Heine method, which is applied in the post-treatment field of continuous preparation of glycine by Hein method, can solve the problems of consuming raw steam, affecting the quality and yield of glycine, etc., and achieve the effect of improving product purity

Inactive Publication Date: 2019-06-28
山西华阳集团新能股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] During the high-temperature hydrolysis process and concentrated crystallization and recrystallization process of hydantoin, by-products such as hydantoin acid, hydantoin amide, glycinamide, glycine dipeptide, polypeptide and 2,5-diketopiperazine will be formed. These by-products The existence of glycine will affect the quality and yield of glycine, and a large amount of raw steam will be consumed during the evaporation and concentration of glycine aqueous solution

Method used

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  • Aftertreatment technology of hydantion serialization preparation of glycine
  • Aftertreatment technology of hydantion serialization preparation of glycine

Examples

Experimental program
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Effect test

Embodiment 1

[0044] The glycine aqueous solution prepared continuously by hydantoin method is as follows: 3.85wt% glycine, 1.21wt% hydantoin, 0.11wt% hydantoin, 0.05wt% hydantoin amide, 0.03wt% 2,5-diketopiperazine, Glycinamide 0.06 wt%.

[0045] Post-process as follows:

[0046] The glycine aqueous solution was transported to the MVR, the evaporation temperature was 60° C., the time was 2.5 h, and the evaporation was concentrated under vacuum conditions. The concentrated solution is sent to the crystallization kettle, the crystallization temperature is 15°C, the rotation speed is 25r / min, after cooling down for 2.5h, the centrifuge is centrifuged at 1000r / min until no liquid flows out. Dissolve glycine crystals in deionized water at a ratio of 40g / 100mL, add 0.5% activated carbon (based on the mass of glycine), heat up to 70°C, and stir at 35r / min for 0.5h. After filtration, the filtrate was poured into a recrystallization kettle, and recrystallized at 10°C and 20r / min for 3h. Then, ce...

Embodiment 2

[0048] The glycine aqueous solution prepared continuously by hydantoin method is as follows: 3.85wt% glycine, 1.21wt% hydantoin, 0.11wt% hydantoin, 0.05wt% hydantoin amide, 0.03wt% 2,5-diketopiperazine, Glycinamide 0.06 wt%.

[0049] Post-process as follows:

[0050] The glycine aqueous solution was transported to the MVR, the evaporation temperature was 70° C., the time was 2 hours, and the evaporation and concentration were carried out under vacuum conditions. The concentrated solution is sent to the crystallization tank, the crystallization temperature is 15°C, the rotation speed is 30r / min, after cooling down for 2 hours, it is centrifuged in the centrifuge at 1000r / min until no liquid flows out. Dissolve glycine crystals in deionized water at a ratio of 40g / 100mL, add 1% activated carbon (according to the mass of glycine), raise the temperature to 75°C, and stir at 60r / min for 0.5h. After filtration, the filtrate was poured into a recrystallization kettle, and recrystal...

Embodiment 3

[0052] The glycine aqueous solution prepared continuously by hydantoin method is as follows: 3.85wt% glycine, 1.21wt% hydantoin, 0.11wt% hydantoin, 0.05wt% hydantoin amide, 0.03wt% 2,5-diketopiperazine, Glycinamide 0.06 wt%.

[0053] Post-process as follows:

[0054] The glycine aqueous solution was transported to the MVR, the evaporation temperature was 70° C., the time was 2 hours, and the evaporation and concentration were carried out under vacuum conditions. The concentrated solution is sent to the crystallization kettle, the crystallization temperature is 15°C, the rotation speed is 25r / min, after cooling down for 2.5h, the centrifuge is centrifuged at 1000r / min until no liquid flows out. Dissolve glycine crystals in deionized water at a ratio of 45g / 100mL, add 0.8% activated carbon (according to the mass of glycine), heat up to 80°C, and stir at 45r / min for 0.5h. After filtration, the filtrate was poured into a recrystallization kettle, and recrystallized at 10°C and 3...

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Abstract

The invention provides an aftertreatment technology of hydantion serialization preparation of glycine. The technology comprises the steps that a steam machine re-compression technology is adopted forevaporating and concentrating a glycine aqueous solution to obtain a concentration solution, and the glycine aqueous solution is obtained in the mode that glycollic nitrile, an ammonia source and a carbon source are subjected to synthesis and hydrolysis reactions in sequence; the concentration solution is subjected to crystallization and purification to obtain glycine crystals and a glycine mothersolution; the glycine crystals are subjected to recrystallization and purification to obtain a glycine product and a recrystallization mother solution; the crystallization mother solution and the recrystallization mother solution are circulated to a hydrolysis reaction kettle, and the crystallization mother solution, the recrystallization mother solution and a synthetic reaction solution are hydrolyzed. According to the aftertreatment technology, in the evaporation and concentration process, live steam does not need to be consumed, the crystallization mother solution and the recrystallizationmother solution are circulated to the hydrolysis reaction kettle for continuous hydrolysis, the loss of the glycine can be reduced, and the quality of the glycine can be improved.

Description

technical field [0001] The invention relates to the field of fine chemicals, in particular to a post-treatment process for the continuous preparation of glycine by the Hyne method. Background technique [0002] Glycine (Glycine), also known as aminoacetic acid, has a chemical formula of C 2 h 5 NO 2 , as an important fine chemical intermediate, it is widely used in the fields of pesticides, medicines, food, feed agents and cosmetics. Glycine synthesis techniques mainly include chloroacetic acid ammonolysis method, Strecker method, and Hydantion method. Among them, the Hein method is to obtain glycine through synthesis and hydrolysis reaction of hydroxyacetonitrile, ammonia source and carbon source at a certain temperature and pressure. This method has the advantages of high atomic utilization rate, high product quality, clean and environmental protection, etc., and has great application prospects. [0003] During the high-temperature hydrolysis process and concentrated ...

Claims

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Application Information

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IPC IPC(8): C07C229/08C07C227/00C07C227/42
Inventor 杨仁俊龚文照张伟赫瑞元赵广李鑫韩萌毋楠袁秋华李伟斌
Owner 山西华阳集团新能股份有限公司
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