A preparation method and application of glutathione-responsive vanadium oxide nanoparticles
A vanadium oxide and nanoparticle technology is applied in the field of preparation of glutathione-responsive vanadium oxide nanoparticles, which can solve problems such as limited application, and achieve the effects of good biocompatibility, broad application prospects and simple operation.
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Embodiment 1
[0024] The preparation of glutathione-responsive vanadium oxide nanoparticles comprises the following steps:
[0025] 1) Dissolve 0.5 g of ammonium metavanadate in 20 mL of distilled water, 0.5 g of hyaluronic acid in 50 mL of distilled water, stir well, and set aside;
[0026] 2) Heat ammonium metavanadate to 80°C and react for 20 minutes to obtain a golden yellow solution, that is, vanadium oxide solution A;
[0027] 3) Add the vanadium oxide solution A dropwise into the hyaluronic acid solution, stir evenly, transfer it to a high-temperature and high-pressure reactor, and stop heating after reacting at 90°C for 6 hours to obtain the hyaluronic acid-modified vanadium oxide solution B ;
[0028] 4) Add an equal volume of ethanol to the aqueous solution B obtained in the previous step, and centrifuge to obtain a yellow solid C;
[0029] 5) Wash solid C three times with ethanol, then centrifuge to obtain solid D;
[0030] 6) Dry the solid D in vacuum to obtain glutathione-re...
Embodiment 2
[0032] The preparation of glutathione-responsive vanadium oxide nanoparticles comprises the following steps:
[0033] 1) Dissolve 0.5 g of ammonium metavanadate in 20 mL of distilled water, 0.5 g of hyaluronic acid in 50 mL of distilled water, stir well, and set aside;
[0034] 2) Heat ammonium metavanadate to 80°C and react for 20 minutes to obtain a golden yellow solution, that is, vanadium oxide solution A;
[0035] 3) Add the vanadium oxide solution A dropwise into the hyaluronic acid solution, stir evenly, then transfer it to a high-temperature and high-pressure reactor, react at 90°C for 6 hours, and stop heating to obtain hyaluronic acid-modified vanadium oxide Solution B;
[0036] 4) Add an equal volume of ethanol to the aqueous solution B obtained in the previous step, and centrifuge to obtain a yellow solid C;
[0037] 5) Wash solid C three times with ethanol, then centrifuge to obtain solid D;
[0038] 6) Dry the solid D in vacuum to obtain glutathione-responsive...
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