Levofloxacin hydrochloride composition packaged by plastic ampoule
A technology of levofloxacin hydrochloride and a composition, which is applied in the field of pharmaceutical preparation, can solve the problems of increasing insoluble particles and deepening color, and achieves the effect of solving the increase of insoluble particles
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Embodiment 1
[0017] prescription:
[0018]
[0019] Its preparation method is:
[0020] Take 80% of the prescribed amount of water for injection, lower the temperature to 35°C, add the prescribed amount of edetate disodium, sodium metabisulfite, gargaronic acid B, and levofloxacin hydrochloride and stir to dissolve; adjust with 0.1mol / L sodium hydroxide solution When the pH value reaches 3.8, add the prescribed amount of activated carbon to stir and absorb, and filter with a 0.5 μm titanium rod and a 0.22 μm microporous filter respectively. The first equipment makes plastic PP bottles, fills, seals, and sterilizes at 121°C for 15 minutes.
Embodiment 2
[0022] prescription:
[0023]
[0024] crafting process:
[0025] Its preparation method is:
[0026] Take 80% water for injection of prescription quantity, temperature drops to 40 ℃, add disodium edetate, sodium pyrosulfite, levofloxacin hydrochloride of prescription quantity and stir to dissolve; adjust pH value to 4.3 with 0.1mol / L sodium hydroxide solution, add The prescription amount of activated carbon is stirred and adsorbed, filtered with a 0.5μm titanium rod and a 0.22μm microporous filter element respectively, after sampling and testing the semi-finished product is qualified, the final 0.22μm microporous filter element is filtered until the visible foreign matter is qualified, and a plastic PP bottle is made with a three-in-one equipment , filling, sealing, and sterilization at 121°C for 15 minutes.
Embodiment 1
[0028] prescription:
[0029]
[0030] Its preparation method is:
[0031] Take 80% of the prescribed amount of water for injection, the temperature drops to 40°C, add the prescribed amount of levofloxacin hydrochloride and stir to dissolve; adjust the pH value to 4.3 with 0.1mol / L sodium hydroxide solution, add the prescribed amount of activated carbon and stir for adsorption, and use 0.5 μm titanium rod and 0.22μm microporous filter element to filter. After sampling and testing the semi-finished product is qualified, the terminal 0.22μm microporous filter element is filtered until the visible foreign matter is qualified, and the three-in-one equipment is used to make plastic PP bottles, fill, seal, and extinguish at 121°C. Bacteria for 15 minutes.
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