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Hypotensive substance aiming at hypertension during pregnancy, application and preparation method of substance

A material and seed technology, applied in the field of blood pressure-lowering substances, can solve the problems of no medicine available and limited antihypertensive effect of magnesium sulfate

Inactive Publication Date: 2019-05-24
徐爽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the antihypertensive effect of magnesium sulfate is very limited
[0007] Generally speaking, patients with hypertension during pregnancy are still in the predicament of having no drugs available, so they can only induce labor in advance or cesarean section

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 100kg fresh Hevea brasiliensis Seeds are used as raw materials, and after drying and shelling, 40 kg of seed kernels are prepared. The seed kernel material is heated to 80-100°C, and then statically extruded at a pressure of 50MPa to obtain 12kg Hevea brasiliensis Fat-soluble substances of seeds.

[0027] Extracted in 10 kg from Hevea brasiliensis The fat-soluble substance of the seeds is used as the raw material. Under the vacuum condition of 0.01Pa, the temperature of the raw material is programmed to rise, the initial temperature is 120°C, and steam is passed into it for distillation, and the distillation termination temperature is 200°C. The gaseous molecules carried by the water vapor are condensed, and the oily substance in the upper layer is the hypotensive substance of the present invention.

[0028] As a control, 10 kg of the fat-soluble substance obtained from flaxseed was used as a raw material, and under the same conditions, the distillation product of th...

Embodiment 2

[0032] 100kg fresh Hevea brasiliensis Seeds are used as raw materials, and after drying and shelling, 40 kg of seed kernels are prepared. The seed kernel material is heated to 80-100°C, and then statically extruded at a pressure of 50MPa to obtain 12kg Hevea brasiliensis Fat-soluble substances of seeds.

[0033] Extracted in 10 kg from Hevea brasiliensis The fat-soluble substance of the seeds is used as the raw material. Under the vacuum condition of 0.5 Pa, the temperature of the raw material is programmed to rise, the initial temperature is 140° C., the ending temperature is 220° C., and nitrogen gas is passed into it for distillation. The gaseous molecules carried out by nitrogen are condensed, and the oily substance is the hypotensive substance of the present invention.

[0034] As a control, 10 kg of the fat-soluble substance obtained from perilla seeds was used as a raw material, and under the same conditions, the distillation product of the fat-soluble substance of p...

Embodiment 3

[0038] 100kg fresh Hevea brasiliensis Seeds are used as raw materials, and after drying and shelling, 40 kg of seed kernels are prepared. The seed kernel material is heated to 80-100°C, and then undergoes dynamic screw extrusion. The screw extrusion time is about 45 seconds, and the fat-soluble substance of 15kg seeds is extruded.

[0039] Extracted in 10 kg from Hevea brasiliensis The fat-soluble substance of the seeds is used as the raw material. Under the vacuum condition of 15Pa, the temperature of the raw material is programmed to rise. The gaseous molecules carried by the carbon dioxide are condensed, and the oily substance is the hypotensive substance of the present invention.

[0040] As a contrast, 10 kg of fat-soluble substances from corn germ were used as raw material, and under the same conditions, the distillation product of fat-soluble substances from corn germ was prepared.

[0041] Pregnant woman C, aged 31, developed gestational hypertension at the 22nd wee...

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Abstract

The invention discloses a hypotensive substance aiming at hypertension during pregnancy, an application and a preparation method of the substance. The substance is a distillation product of a fat-soluble substance of a seed of a plant Hevea brasiliensis. The method includes taking the fat-soluble substance extracted from the seed of the Hevea brasiliensis as a raw material; preforming temperatureprogramming on the raw material under a vacuum condition; introducing steam or inert carrier gas for distillation; and condensing gaseous molecules carried by the steam or the inert carrier gas to obtain the substance. The substance can be applied to medicines, health foods and foods, and can be used for reducing blood pressure of patients with hypertension during pregnancy, has no side effect, and is very safe for mothers and infants.

Description

technical field [0001] The invention discloses a blood pressure-lowering substance aimed at hypertension during pregnancy, its application and its preparation method, belonging to the fields of medicine and food. Background technique [0002] Hypertensive disorders of pregnancy are specific diseases of pregnant women, including gestational hypertension, preeclampsia, eclampsia, chronic hypertension complicated by preeclampsia, and chronic hypertension. The incidence rate is 9.4% in my country, and 7% to 12% in foreign reports. The disease seriously affects the health of mothers and infants, and is one of the main causes of maternal and perinatal morbidity and death. [0003] Its clinical manifestations include high blood pressure, edema, and proteinuria in pregnant women around 20 weeks of pregnancy. In mild cases, it may be asymptomatic or mild dizziness, and blood pressure may increase slightly, accompanied by edema or mild proteinuria; in severe cases, headache, vertigo,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/47A61P15/00A61P9/12
Inventor 徐爽
Owner 徐爽
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