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Ester exchange catalyst with biological activity, synthesis method of ester exchange catalyst, and application of ester exchange catalyst to preparation of degradable polyester

A transesterification catalyst and biologically active technology, applied in the field of transesterification catalysts, can solve the problems of not being able to apply synthetic biological polyester materials, increase the production cost of polyester materials, and cumbersome catalyst synthesis, and achieve good market space and value, excellent Catalytic activity, low cost effect

Active Publication Date: 2019-05-17
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composite catalyst is a combination of ethylene glycol magnesium and ethylene glycol antimony. Because antimony metals are poisonous, this catalyst cannot be used to synthesize bio-polyester materials
And the synthesis of catalyst is loaded down with trivial details, increases the production cost of polyester material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] (1) Add 10 grams of analytically pure 1,4-butanediol to a 250 mL three-necked flask equipped with a mechanical stirrer, a thermometer, a nitrogen gas inlet tube, a condenser, etc., add 0.35 grams of magnesium powder, and pass in argon, Heated to 120° C., reacted for 6 hours under stirring at 100 r.p.m, cooled and aged for 1 hour with stirring, to obtain 2.5 grams of magnesium butanediol with catalytic activity.

[0051] (2) Take another 250mL three-necked flask equipped with a mechanical stirrer, thermometer, nitrogen inlet tube, condenser, etc., add 16.3 grams of dimethyl succinate (112 mmol), 15 grams of 1,4-butanediol (166 mmol), fed with argon, gradually heated to 180°C, and reacted under stirring at 100r.p.m. The methanol produced was removed by condensation, and the reaction stopped when no methanol was produced.

[0052] (3) Cool down afterwards, add 0.35 gram of butanediol magnesium as transesterification catalyst. Then gradually raise the temperature to 230°C,...

Embodiment 2～5

[0066] The synthesis process is the same as in Example 1, except that the dimethyl succinate in the synthetic polyester process is replaced by dimethyl glutarate, dimethyl adipate, dimethyl pimelate, and suberic acid respectively. Dimethyl ester. The viscosity-average molecular weights of the obtained polyester products were 47kDa, 40kDa, 29kDa, and 22kDa, respectively.

Embodiment 6～9

[0068] Synthetic technique is the same as embodiment 1, and difference only is that the butanediol in synthetic polyester process is replaced with pentanediol, hexanediol, heptanediol, octanediol respectively. Transesterification catalyst is changed into corresponding glycol magnesium, and the viscosity-average molecular weight of gained polyester product is respectively 35kDa, 32kDa, 30kDa, 23 kDa.

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Abstract

The invention discloses an ester exchange catalyst with biological activity, a synthesis method of the ester exchange catalyst, and application of the ester exchange catalyst to preparation of degradable polyester. The synthesis method of the ester exchange catalyst comprises the steps that a simple substance M and dihydric alcohol A are mixed and heated to the boiling point temperature or above of the dihydric alcohol A, a reaction is conducted under the condensation reflux condition, and the ester exchange catalyst is obtained through stirring and aging; the simple substance M is selected from one or more of metal magnesium, calcium and strontium; the general molecular formula of the dihydric alcohol A is HO(CH2)<m>OH, and m is selected from 2 to 10; and the mass ratio of the simple substance M to the dihydric alcohol A is (0.001 to 0.5):1. The ester exchange catalyst is further applied to the synthesis field of the degradable polyester, and the finally prepared degradable polyesterhas the high molecular weight and the biological activity, and can be applied to the biomedical field.

Description

technical field [0001] The present invention relates to the technical field of transesterification catalysts, in particular to a biologically active transesterification catalyst and its synthesis method and application in the preparation of degradable polyesters. Background technique [0002] Degradable materials are a class of products that can be degraded into small molecules that are harmless to the environment under the action of factors such as light, heat, oxygen, water, and microorganisms in the natural environment. At present, countries all over the world are vigorously carrying out research on such products. In the current research on degradable materials, polyester degradable materials occupy an important position. Since the aliphatic polyester polymer chain contains ester bonds, it is easily hydrolyzed or degraded by microorganisms into small molecules such as water and carbon dioxide. For example, surgical sutures used in biomaterials, traditional surgical sutu...

Claims

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Application Information

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IPC IPC(8): C07C29/70C07C31/28C07C31/30C08G63/16C08G63/83
Inventor 朱蔚璞张洪杰蔡秋泉
Owner ZHEJIANG UNIV
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