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Medical polyurethane adhesive and preparation method thereof

A technology of polyurethane adhesives and polycondensation products, applied in the direction of polyurea/polyurethane adhesives, adhesive types, adhesives, etc., can solve problems such as the risk of carrying viruses, poor adhesion, and difficulty in mass production, and achieve Good formulation adjustability and adaptability, improved biological applicability, and the effect of promoting good performance

Inactive Publication Date: 2019-05-14
SOUTH CHINA UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem with these types of medical adhesives is that chitosan contains a lot of -NH 2 , is positively charged under physiological conditions, and has poor adhesion to tissues when used alone; in addition to high cost of protein-based adhesives, fibrin adhesives also have relatively weak adhesive strength and degrade too quickly and the risk of carrying viruses, so that it is only used for small incisions in loose skin; mass production of bionic tissue adhesives such as mussel mucin MAP is difficult to achieve because of its low extraction rate and harsh storage conditions. higher cost
US5578662 describes the use of organotins as catalysts in all examples, with corresponding toxicity

Method used

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  • Medical polyurethane adhesive and preparation method thereof
  • Medical polyurethane adhesive and preparation method thereof
  • Medical polyurethane adhesive and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] (1) Add 0.24g of PEG with a molecular weight of 400 into a 500mL four-necked flask equipped with a stirrer and a thermometer, and carry out stirring and dehydration treatment at 110°C under a vacuum of 0.1MPa, with a stirring speed of 1200r / min for a time of 3h, to obtain dehydrated polyether polyol. The maltodextrin with a DB value of 10 was placed in a vacuum of 0.08MPa and dried at 60°C for 24h.

[0071] (2) Cool down the dehydrated polyether polyol in step (1) to 70°C, then add 0.62g of triethylamine, 30.0g of dimethyl sulfoxide, and 68.91g of IPDI while blowing nitrogen, and stir the reaction at 70°C for 1.5 h, the stirring speed is 700r / min, and the end-NCO polyurethane prepolymer is prepared. During this period, according to the change of the viscosity, the speed of the stirrer was adjusted at any time and an appropriate amount of dimethyl sulfoxide was added.

[0072] (3) Add dimethyl sulfoxide to the end-NCO prepolymer obtained in step (2) to adjust the visco...

Embodiment 2

[0077] (1) Add 0.24g of PEG with a molecular weight of 400 into a 500mL four-neck flask equipped with a stirrer and a thermometer, and carry out stirring and dehydration treatment at 100°C under a vacuum of 0.1MPa, with a stirring speed of 1200r / min for a time of 3h, to obtain dehydrated polyether polyol. The maltodextrin with a DB value of 15 was placed in a vacuum of 0.1 MPa and dried at 70° C. for 48 hours.

[0078] (2) Cool down the dehydrated polyether polyol in step (1) to 75°C, then add 0.32g triethylamine and 0.30g triethanolamine, 50.0g N,N-dimethylformamide, 68.91g IPDI, stirred and reacted at 75° C. for 1 h, and the stirring speed was 800 r / min, to obtain a terminal-NCO polyurethane prepolymer. During this period, according to the change of viscosity, adjust the speed of the stirrer at any time and add an appropriate amount of N,N-dimethylformamide.

[0079] (3) Add N,N-dimethylformamide to the terminal-NCO prepolymer obtained in step (2) to adjust the viscosity, th...

Embodiment 3

[0084] (1) Add 0.24g of PEG with a molecular weight of 400 into a 500mL four-necked flask equipped with a stirrer and a thermometer, and carry out stirring and dehydration treatment at 105°C under a vacuum of 0.05MPa, with a stirring speed of 1000r / min for a time of 3h, to obtain dehydrated polyether polyol. The amylose was placed in a vacuum of 0.08MPa and dried at 60°C for 48h.

[0085] (2) Lower the temperature of the dehydrated polyether polyol in step (1) to 65°C, then add 0.66g of diethylenetriamine, 30.0g of tetrahydrofuran, and 77.58g of MDI while blowing nitrogen, and stir the reaction at 65°C for 1.5h, then stir The speed is 600r / min, and the end-NCO polyurethane prepolymer is prepared. During this period, according to the change of the viscosity, the speed of the stirrer was adjusted at any time and an appropriate amount of tetrahydrofuran was added.

[0086] (3) Add tetrahydrofuran to the terminal-NCO prepolymer obtained in step (2) to adjust the viscosity, then ...

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Abstract

The invention belongs to the field of medical materials and discloses a medical polyurethane adhesive and a preparation method thereof. The preparation method comprises the following steps of mixing the dehydrated polyether polyol with an amine catalyst, an organic solvent and a diisocyanate under the condition of introducing nitrogen gas and stirring, and reacting the mixture to obtain a NCO (Isocyanate)-terminated polyurethane prepolymer; adding a castor oil or a derivative thereof to the obtained NCO-terminated polyurethane prepolymer, and reacting the mixture to obtain a castor oil-modified polyurethane prepolymer solution; adding a polysaccharide substance into the obtained castor oil-modified polyurethane prepolymer solution, and reacting the mixture to obtain a polysaccharide-castoroil modified hyperbranched polyurethane prepolymer solution, wherein the polysaccharide substance is any one or more than two of maltodextrin, amylose and hyaluronic acid; after completion of the reaction, removing the organic solvent to obtain the medical polyurethane adhesive. According to the medical polyurethane adhesive and the preparation method thereof disclosed by the invention, the castor oil or the derivative thereof and the polysaccharide material are used as a bio-based polyol, and the obtained polyurethane adhesive has remarkably improved biocompatibility.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a medical high-performance polyurethane adhesive and a preparation method thereof. Background technique [0002] Medical adhesives are gradually becoming a competitive technology that supplements or even replaces surgical sutures. This suture method can prevent air and fluid leakage during and after surgery. In addition, it is easy to operate, short in operation time, Non-invasive, painless and other advantages. [0003] The key issue in the clinical application of medical adhesives is to develop and design a product with suitable physical and chemical indicators and bonding strength, so that it will not affect the movement and function of surrounding tissues when it is coated on the wound. Commercially available medical adhesives are derived from natural biomass modification, artificially synthesized polymers, or a combination of the two. These include the cyanoacrylates Derma...

Claims

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Application Information

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IPC IPC(8): C09J175/14C09J175/08C08G18/75C08G18/66C08G18/48C08G18/64C08G18/36C08G18/10
Inventor 夏正斌苏秋岚魏丹戴伟钢张燕红
Owner SOUTH CHINA UNIV OF TECH
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