Treatment method for rubber plug used for aspirin-dl-lysine production

A technology of lysine and a treatment method, which is applied in the directions of cleaning methods, chemical instruments and methods, cleaning methods and utensils using liquids, etc. Improve production efficiency and reduce the effect of transshipment links

Inactive Publication Date: 2019-05-10
YANGZHOU YIYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Conventional transportation methods include the following three types: (1) Human transportation, which is labor-intensive, low-efficiency, and prone to errors and pollution
(2) Mechanical transportation, such as conveyor belts, conveyors, etc., this kind of transportation is in a fully open or semi-open state, which is likely to cause material pollution
This method of operation is time-consuming, labor-intensive, low-efficiency, and prone to errors and pollution.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Treatment of rubber stoppers used in the production of lysine-pirin powder injection

[0030] (1) Rubber stopper cleaning: Use a fully automatic wet air flushing rubber stopper cleaning machine to clean and disinfect the rubber stoppers. The process conditions are as follows: rough cleaning for 2 minutes, rinsing for 3 minutes, fine cleaning for 8 minutes, siliconization for 3 minutes, rinse and drain 3 minutes, pure steam sterilization at 121°C for 25 minutes, vacuum drying for 15 minutes, hot air drying at 105°C for 20 minutes-vacuuming for 10 minutes; clean compressed air to make the machine normal pressure and cool down, and observe that the temperature drops to 60°C Then click the shutdown button, the cleaned rubber plugs are stored in the machine, and are ready to be used in the packaging process; the 105°C hot air drying for 20 minutes-vacuumizing for 10 minutes is a total of 3 cycles; the pure steam sterilization The process conditions are: evacuate to -65KPa an...

Embodiment 2

[0035] Treatment of rubber stoppers used in the production of lysine-pirin powder injection

[0036] (1) Rubber stopper cleaning: use a fully automatic wet air flushing rubber stopper cleaning machine to clean and disinfect the rubber stoppers. The process conditions are as follows: rough cleaning for 5 minutes, rinsing for 8 minutes, fine cleaning for 12 minutes, silicification for 6 minutes, rinse and drain 8 minutes, pure steam sterilization at 121°C for 35 minutes, vacuum drying for 25 minutes, hot air drying at 105°C for 20 minutes-vacuumizing for 10 minutes; clean compressed air was introduced to make the machine normal pressure and cool down, and the observed temperature dropped to 60°C Then click the shutdown button, the cleaned rubber plugs are stored in the machine, and are ready to be used in the packaging process; the 105°C hot air drying for 20 minutes-vacuumizing for 10 minutes is a total of 3 cycles; the pure steam sterilization The process conditions are: evacu...

Embodiment 3

[0041] Treatment of rubber stoppers used in the production of lysine-pirin powder injection

[0042] (1) Rubber stopper cleaning: use a fully automatic wet air flushing rubber stopper cleaning machine to clean and disinfect the rubber stoppers. The process conditions are as follows: rough cleaning for 3 minutes, rinsing for 5 minutes, fine cleaning for 10 minutes, silicification for 5 minutes, rinse and drain 5 minutes, pure steam sterilization at 121°C for 30 minutes, vacuum drying for 20 minutes, hot air drying at 105°C for 20 minutes-vacuuming for 10 minutes; clean compressed air is introduced to make the machine normal pressure and cool down, and the temperature drops to 60°C Then click the shutdown button, the cleaned rubber plugs are stored in the machine, and are ready to be used in the packaging process; the 105°C hot air drying for 20 minutes-vacuumizing for 10 minutes is a total of 3 cycles; the pure steam sterilization The process conditions are: evacuate to -65KPa ...

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Abstract

The invention relates to a treatment method for a rubber plug used for aspirin-dl-lysine production. The treatment method includes the steps that firstly, the rubber plug is cleaned, wherein a full-automatic wet process gas rushing type rubber plug cleaning machine is used for conducting cleaning and disinfecting on the rubber plug, the technology conditions include that rough cleaning is conducted for 2 min to 5 min, rinsing is conducted for 3 min to 8 min, fine cleaning is conducted for 8 min to 12 min, silicification is conducted for 3 min to 6 min, flushing and draining are conducted for 3min to 8 min, pure steam sterilizing is conducted for sterilizing for 25 min to 35 min under the temperature of 121 DEG C, vacuum drying is conducted for 15 min to 25 min, hot air drying is conductedfor 20 min at the temperature of 105 DEG C, and vacuum pumping is conducted for 10 min at the temperature of 105 DEG C; and secondly, plug discharging is conducted, wherein sealing barrels are movedinto an isolation cabinet at the discharging end of the rubber plug in a paired manner, self cleaning is conducted for 10 min, and then the sealing barrels are taken out and transported into a split packaging machine to be in horizontal butt joint with a tabletop of a storage material barrel. The treatment method is adopted for treating the rubber plug used for aspirin-dl-lysine powder injection production, the transfer link is emitted under the condition that the sterile state of the rubber plug is ensured, and the production efficiency is improved.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a method for processing rubber stoppers for production of lysine-pirin. Background technique [0002] Lysine Acetylsalicylate for Injection (Lysine Acetylsalicylate for Injection) is a drug approved for marketing in the territory of the People's Republic of China. It is in the form of powder injection and belongs to antipyretic and analgesic drugs. Lysine for injection is in accordance with the "Chinese Pharmacopoeia" 2015 Edition Part II and IV; "National Drug Standard WS1-XG-015-2001Z" for [Storage] item is implemented for quality control. [0003] Lysine for injection is a sterile preparation, and the production process needs to adopt aseptic production process. The latter refers to sterilizing the medicine, container, and sealing components separately, and then combining them together to form the final product. Sterilize again. The aseptic production process emphasizes th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B08B3/02B08B3/08B08B13/00A61L2/07F26B21/00
Inventor 吉宏陈维隽
Owner YANGZHOU YIYANG PHARMA
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