Preparation method of P-type molecular sieve-chitosan-sodium alga acid-potassium diformate slow-release antibacterial agent

Abstract

The invention discloses a P-type molecular sieve-chitosan-sodium alga acid-potassium diformate compound and a method for forming a livestock antibacterial agent with a slow-release effect. The defectsare overcome that heavy metal in a silver zeolite antibacterial agent easily deposits in an organism and cannot be applied to fodder, and potassium diformate as an acidifying agent cannot exert effects in the intestinal tract. With a P-type molecular sieve being a carrier, chitosan and sodium alga acid are sued a bridge. Potassium diformate as the acidifying agent is adsorbed, and the livestock slow-release antibacterial agent is prepared. Acidity detection and in-vitro antibacterial testing show that the slow-release antibacterial agent has slow-release performance, has an excellent antibacterial effect on escherichia coli, and can prevent and treat a diarrheal disease caused by escherichia coli.

Description

technical field [0001] The invention relates to a preparation method for compounding P-type molecular sieves, chitosan, sodium alginate and potassium diformate to prepare slow-release antibacterial agents. Background technique [0002] Guangxi stilbene is the best ore found in the world so far, the raw material is easy to mine, and it can be used as the precursor of synthetic molecular sieve after acidification. The method uses acidified stilbite as a raw material, and prepares P-type zeolite molecular sieves through a hydrothermal synthesis method, controlling reaction time, reaction temperature and other conditions. Using P-type zeolite molecular sieve as carrier, chitosan as intermediate and sodium alginate as coating film, P-type molecular sieve slow-release antibacterial agent was prepared by hydrothermal synthesis. [0003] Potassium diformate, as an efficient and environmentally friendly antibacterial agent, can inhibit the growth of Escherichia coli in the intestine...

AI Technical Summary

Problems solved by technology

[0003] Potassium diformate, as an efficient and environmentally friendly antibacterial agent, can inhibit the growth of Escherichia coli in the intestines of animals, but it decomposes quickly in the stomach and cannot reach the end of the intestinal tract, and cannot play a role in the end of the intestinal tract. To solve this problem One problem, we choose P-type molecular sieve as the carrier of potassium diformate, in order to achieve the effect of sustained release, but P-type molecular sieve can only produce adsorption with potassium diformate, and the slow-release antibacterial effect is not good, while chitosan is A green, non-toxic, harmless polymer material, containing amino groups and a large number of hydroxyl groups, has high surface activity and biological activity, and has certain antibacterial properties. It has been approved by my country as a food additive and can be used A large number of hydroxyl groups in chitosan molecules form hydrogen bonds with molecular sieves and potassium diformate respectively, so that potassium diformate is fixed on molecular sieves; using chitosan and sodium alginate as wall materials, microcapsules are prepared by complex coacervation method , organic compounding of chitosan / sodium alginate / molecular sieve / potassium diformate to achieve the purpose of slow release and antibacterial of potassium diformate in the intestinal tract

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