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Application of cumarin coumpound Murraya jasminorage ketone in preparing anti-tumor medicament

A technology of coumarin and coumarin, which is applied in the field of preparation of anti-tumor drugs by coumarin compound jiurikone, and achieves the effects of high safety, good development and utilization prospects, and low price

Inactive Publication Date: 2010-11-10
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Problems solved by technology

Jiulixiang ketone has good antibacterial and anti-inflammatory effects (1. Zou Lianxin, Zheng Hanchen, Yang Ziren. Research progress of Jiulixiang plants. Journal of Pharmaceutical Practice. 1997; 15(4): 214-219.2. Yan Jie, Pei Jianmei. HPLC method Determination of Jiulixiangone Content in Sanjiuweitai Granules. Chinese Herbal Medicine. 2005; 36(3): 375-376.3. Sui Dayuan, Li Shuhui. Survey of Jiulixiang Chemical and Anti-fertility Research. Chinese Herbal Medicine. 1994; 25(8) : 435-437, 448.), but so far there is no report about its anti-tumor activity

Method used

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  • Application of cumarin coumpound Murraya jasminorage ketone in preparing anti-tumor medicament
  • Application of cumarin coumpound Murraya jasminorage ketone in preparing anti-tumor medicament
  • Application of cumarin coumpound Murraya jasminorage ketone in preparing anti-tumor medicament

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Abstract

The invention relates to the field of medical technology, more particularly to a new use of coumarin compound murrayone in the preparation of antineoplastic drugs. As expressed by in vivo and in vitro experiments, the murrayone has inhibition effect on both the growth of tumor cells and the growth of subcutaneous transplantable tumor of animals, and the experiment for the acute toxicity of animals shows that the acute toxicity of the murrayone is quite low, therefore, the invention can be used for preparing the antineoplastic drugs.

Description

Application of Coumarin Compound Jiulixiangone in the Preparation of Antitumor Drugs technical field The invention relates to the technical field of medicine, in particular to the new application of coumarin compound jiurigenone in preparing antitumor drugs. Background technique Murrayone (murrayone) is a coumarin compound, which can be extracted from Rutaceae Murraya exotica (Murraya exotica L.) and Thyme (Murrayapaniculata (L.) Jack). The body is obtained by semi-synthesizing (Pharmacopoeia Commission of the Ministry of Health of the People's Republic of China. Pharmacopoeia I of the People's Republic of China. 2005: 9.). The chemical structural formula of Jiulixiangone is as follows: Jiulixiang ketone has good antibacterial and anti-inflammatory effects (1. Zou Lianxin, Zheng Hanchen, Yang Ziren. Research progress of Jiulixiang plants. Journal of Pharmaceutical Practice. 1997; 15(4): 214-219.2. Yan Jie, Pei Jianmei. HPLC method Determination of Jiulixiangone Conten...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/37A61P35/00
Inventor 张黎刘厚佳王晓黎高平挥卫立辛芮耀诚吴孟超
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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