Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of imperatorin in the preparation of drugs for inhibiting esophageal cancer

A technology of imperatorin and esophageal cancer is applied in the application field of medicine, and achieves the effects of convenient extraction and preparation, application value of anti-tumor metastasis, and inhibition of metastasis and proliferation.

Active Publication Date: 2020-04-14
JINAN UNIVERSITY
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far there is no better biomarker protein for prevention and treatment of esophageal cancer

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of imperatorin in the preparation of drugs for inhibiting esophageal cancer
  • Application of imperatorin in the preparation of drugs for inhibiting esophageal cancer
  • Application of imperatorin in the preparation of drugs for inhibiting esophageal cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Construction of mouse tumor metastasis model

[0036] Select 18 6-week-old female nude mice (balb / c-nu / nu), 6 mice in the control group and 12 mice in the experimental group to construct a tumor metastasis model:

[0037] (1) Each nude mouse needs to be injected with 10 6 One esophageal cancer cell KYSE150-luc, the cells were resuspended in PBS;

[0038] (2) Anesthetize the nude mice before the experiment, evaluate the degree of anesthesia through painless and painful stimulation, and determine that the nude mice are under anesthesia;

[0039] (3) The resuspended cells were injected into the tail vein of nude mice with a micro-injector with a 25G needle, a total of 18 mice.

[0040] imperatorin-treated mouse model

[0041] One week after injecting KYSE150-luc, the drug was administered by gavage. The imperatorin was dissolved in corn oil, and each mouse was fed with 100 μL corn oil once. In this experiment, three concentration gradients of imperatorin were set up, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of imperatorin in preparing a medicine for inhibiting esophageal carcinoma. According to the invention, functions of the imperatorin, as a conventional Chinese herbal medicine, are explored, discovering that the imperatorin can obviously inhibit the secretion and expression of esophageal carcinoma cell protein TGF-[beta]2, and a scheme is designed; and it isverified that the imperatorin can inhibit metastasis of esophageal carcinoma cells, indicating that the imperatorin has a function of treating the esophageal carcinoma.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to the application of imperatorin in the preparation of drugs for inhibiting esophageal cancer tumors. Background technique [0002] Cancer is one of the most difficult diseases in the world to treat. The deterioration of cancer is often accompanied by the proliferation and metastasis of cancer cells. Once cancer is diagnosed, it will be difficult to treat. The current mainstream treatment method is a combination of surgery and radiotherapy and chemotherapy. In the field of targeted therapy, the angiogenesis factor (VEGF) inhibitor bevacizumab and the epidermal growth factor receptor blocker panitumumab are widely used. , cetuximab and erlotinib. Nevertheless, the clinical efficacy is still unsatisfactory, and the occurrence of chemotherapy resistance and toxic side effects affects the prognosis of cancer patients. Anticancer preparations of natural products generally...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/37A61P35/04A61P1/00
CPCA61K31/37
Inventor 李斌黄智豪何庆瑜许雯雯
Owner JINAN UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com