Method for photocatalytically preparing 3-sulfonyl-1,2-dihydronaphthalene compounds

Abstract

The invention discloses a method for photocatalytically preparing 3-sulfonyl-1,2-dihydronaphthalene compounds. The method employs a methylene cyclopropane compound and sulfonyl chloride as initial rawmaterials, then in the presence of a photocatalyst and visible light, various 3-sulfonyl-1,2-dihydronaphthalene compounds are synthesized through C=C sulfonylation, C-C [sigma]-bond rupture and intramolecular cyclization. The method employs accessible raw materials and mild reaction conditions, is simple in operation, is wide in substrate adaptation range and is high in yield.

Description

technical field [0001] The application belongs to the technical field of organic synthesis, and in particular relates to a preparation method of 3-sulfonyl-1,2-dihydronaphthalene. Background technique [0002] Sulfone-containing compounds are a very unique class of structural units, which have a wide range of applications in the fields of agricultural chemistry, polymer materials, organic synthesis and medicinal chemistry ((1) Org. Lett., 2015, 17, 3552; (2) Chem. Sci.,2018, 9, 3186; (3) J. Org. Chem., 2011, 76, 1001; (4) Org. Chem, Front.,2018, 5, 2604; (5) Adv. Synth. Catal., 2016, 358, 2286; (6) J. Org. Chem., 2018, 83, 10420, etc.). Although organic chemists have developed synthetic methods for some substituted sulfone compounds using the above examples, the method for synthesizing 3-sulfonyl-1,2-dihydronaphthalene compounds has not been reported yet, and more Novel, efficient, and environmentally friendly synthetic methods for 3-sulfonyl-1,2-dihydronaphthalene compoun...

AI Technical Summary

Problems solved by technology

Although organic chemists have developed synthetic methods for some substituted sulfone compounds using the above examples, the method for synthesizing 3-sulfonyl-1,2-dihydronaphthalene compounds has not been reported yet, and more Novel, efficient, environmentally friendly synthetic methods for 3-sulfonyl-1,2-dihydronaphthalene compounds are still necessary for those skilled in the art

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