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Application of tea to preparation of medicines for relieving polyuria symptoms caused by diabetes

A technology for diabetes, medicine, applied in the field of biomedicine

Inactive Publication Date: 2019-05-03
ANHUI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, all kinds of drugs for the treatment of diabetes have not used renal water reabsorption protein as an intervention target

Method used

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  • Application of tea to preparation of medicines for relieving polyuria symptoms caused by diabetes
  • Application of tea to preparation of medicines for relieving polyuria symptoms caused by diabetes
  • Application of tea to preparation of medicines for relieving polyuria symptoms caused by diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Green tea reduces urine output and lowers blood sugar by increasing kidney PKC-α and AQP2 in type 1 diabetic mice

[0037] Experimental animals: male Kunming rats, weighing 18-20g. Establishment of type 1 diabetes mouse model: 18-20g mice were fasted overnight, intraperitoneally injected with 200mg / kg alloxan once; one week after the injection, fasted overnight again, and fasting blood glucose was measured, and the model was considered successful when the blood glucose value was greater than 11mmol / L , and randomly grouped by blood glucose. Intervention plan: the mice were divided into three groups, 5 in the normal control group, 6 in the diabetes model group, and 9 in the green tea intervention group of diabetic model mice. The green tea group was intervened with green tea soup (1 / 90, w / v), and the other groups were given pure water, and each group was free to drink. The tea soup was changed every day, and the urine output was recorded every day. The experi...

Embodiment 2

[0039] Embodiment 2 Green tea reduces urine output and lowers blood sugar by increasing kidney PKC-α, AQP2 and UT-A1 in type 2 diabetes db / db mice

[0040]Experimental animals: db / db mice, body weight 35-40g. Intervention plan: 12 db / db mice aged 8 weeks were randomly divided into two groups according to blood sugar, db / db group and green tea group, green tea group was intervened with tea soup (1 / 30, w / v), db / db group Use pure water, drink freely. The tea soup was changed every day, and the urine output was recorded every day. The experimental period was 4 weeks, during which blood sugar was monitored. After 4 weeks of intervention, the experiment was ended, kidney tissues were collected, and protein expression was detected by Western Blot.

[0041] Experimental results and conclusions: the daily urine output of normal C57 mice is 2-3mL, figure 2 A and B show that type 2 diabetic db / db mice urinate significantly more than normal mice. On the first day of drinking green tea...

Embodiment 3

[0042] Embodiment 3 Black tea reduces urine output and lowers blood sugar by increasing kidney PKC-α, AQP2 and UT-A1 in type 2 diabetes db / db mice

[0043] Experimental animals: db / db mice, body weight 35-40g. Intervention plan: 12 db / db mice aged 8 weeks were randomly divided into 2 groups according to blood sugar, db / db group and black tea group, black tea group was intervened with tea soup (1 / 30, w / v), db / db group Use pure water, drink freely. The tea soup was changed every day, and the urine output was recorded every day. The experimental period was 4 weeks, during which blood sugar was monitored. After 4 weeks of intervention, the experiment was ended, kidney tissues were collected, and protein expression was detected by Western Blot.

[0044] Experimental results and conclusions: image 3 A and B show that on the first day of drinking black tea, the urine output of diabetic mice can be strongly corrected to a normal level, and the effect is long-lasting. The above re...

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Abstract

The invention relates to an application of tea to preparation of medicines for relieving polyuria symptoms caused by diabetes, and discloses the tea which can quickly, strongly and durably improve thepolyuria symptoms of patients suffering from diabetes. The mechanism of the application lies in that the tea can notably increase the expression amount of kidney protein kinase C, aquaporin or urea transport protein of the patients suffering from polyuria, and can promote the membrane shift of the kidney protein kinase C, the aquaporin or the urea transport protein, so that the reabsorption capacity of kidney to water is reinforced, the micturition is reduced, and the blood sugar is reduced. The invention provides a new policy for effective improvement of the polyuria symptoms of the patientssuffering from diabetes, and reducing blood sugar.

Description

technical field [0001] The field of biomedicine of the present invention, specifically, relates to the application of tea in the preparation of the medicine for alleviating the symptoms of diabetes and polyuria. Background technique [0002] Hyperglycemia and polyuria are typical symptoms of diabetes. Currently, there are two main methods for the treatment of diabetes. One is to reduce the intestinal intake of glucose by inhibiting the activity of α-glucosidase. Such drugs mainly include acarbose, voglibose and mig The second is through the insulin pathway, including insulin sensitizers, insulin secretagogues and insulin injections, such drugs mainly include biguanides, thiazolidinediones, sulfonylureas and non-sulfonylureas. The above-mentioned drugs are all drugs targeting the characteristics of hyperglycemia. Diabetic polyuria is a pathophysiological response to reduced circulating glucose due to hyperosmolarity produced by hyperglycemia. However, due to the loss of su...

Claims

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Application Information

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IPC IPC(8): A61K36/82A61K31/522A61K31/353A61P3/10A61P13/00
Inventor 张劲松赵广山
Owner ANHUI AGRICULTURAL UNIVERSITY
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