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Application of ginseng GUBEN preparation in preparation of medicine for treating type II diabetes and preparation method thereof

A diabetes drug and diabetes technology, which are applied to traditional Chinese medicine compositions, and the application field of ginseng solid preparations in the preparation and treatment of type II diabetes drugs, can solve the problems of lactic acidosis, hypoglycemia, hidden dangers of drug use in patients, etc.

Pending Publication Date: 2021-09-07
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the disadvantages of sulfonylureas are more likely to cause adverse reactions such as hypoglycemia, neutropenia, and cardiovascular diseases.
Large doses of biguanides can cause gastrointestinal reactions, which can easily lead to lactic acidosis in patients with lung, liver, and kidney lesions, bringing hidden dangers to the majority of patients

Method used

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  • Application of ginseng GUBEN preparation in preparation of medicine for treating type II diabetes and preparation method thereof
  • Application of ginseng GUBEN preparation in preparation of medicine for treating type II diabetes and preparation method thereof
  • Application of ginseng GUBEN preparation in preparation of medicine for treating type II diabetes and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0143] The preparation of embodiment 1 oral liquid

[0144]

[0145] A. Take Moutan cortex, add 10 times the amount of water to distill and extract paeonol to the end, cool down the paeonol aqueous solution, filter to obtain paeonol, and set aside, medicinal residue Ⅰ and medicinal solution Ⅰ for subsequent use.

[0146] B. Take ginseng and Cornus officinalis, extract twice with 60% ethanol under reflux, first extract with 10 times the amount of ethanol for 1.5 hours, and secondly extract with 8 times the amount of ethanol for 1 hour, filter, and combine the filtrates to obtain alcohol extract I. Standby, medicinal dregs II are spare;

[0147] C. Take medicinal residue Ⅰ, medicinal residue Ⅱ and step A liquid, add rehmannia glutinosa, rehmannia glutinosa, asparagus, radix radices, yam, Alisma and Poria, add water to decoct 2 times, extract 1.5 hours with 10 times the amount of water for the first time , the second 8 times the amount of water extraction for 1 hour, combined...

Embodiment 2

[0149] The preparation of embodiment 2 capsules

[0150]

[0151] A. Take Moutan cortex, add 10 times the amount of water to distill and extract paeonol to the end, cool down the paeonol aqueous solution, filter to obtain paeonol, and set aside, medicinal residue Ⅰ and medicinal solution Ⅰ for subsequent use.

[0152] B. Take ginseng and Cornus officinalis, extract twice with 70% ethanol under reflux, first extract with 9 times the amount of ethanol for 1 hour, and secondly extract with 9 times the amount of ethanol for 1 hour, filter, and combine the filtrates to obtain alcohol extract I. Standby, medicinal dregs II for standby;

[0153] C. Take medicinal residue Ⅰ, medicinal residue Ⅱ and step A liquid, add rehmannia glutinosa, rehmannia glutinosa, asparagus, radix radices, yam, Alisma and Poria, add water to decoct 2 times, extract 9 times the amount of water for 1.5 hours for the first time , the second time 8 times the amount of water extraction for 1.5 hours, combine...

Embodiment 3

[0155] The preparation of embodiment 3 tablet

[0156]

[0157] A. Take Moutan cortex, add 8 times the amount of water to distill and extract paeonol to the end, cool down paeonol aqueous solution, filter to obtain paeonol, and set aside, medicinal residue Ⅰ and medicinal solution Ⅰ for subsequent use.

[0158] B. Take ginseng and Cornus officinalis, extract twice with 50% ethanol under reflux, first extract with 10 times the amount of ethanol for 2 hours, and secondly extract with 9 times the amount of ethanol for 1.5 hours, filter, and combine the filtrates to obtain alcohol extract I. Standby, medicinal dregs II for standby;

[0159] C. Take medicinal residues Ⅰ, medicinal residues Ⅱ and step A medicinal liquid, add rehmannia glutinosa, rehmannia glutinosa, asparagus, radix japonicus, yam, Alisma and poria, add water to decoct 2 times, extract 10 times the amount of water for 2 hours for the first time , the second time 8 times the amount of water extraction for 1 hour,...

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Abstract

The invention discloses application of a ginseng GUBEN preparation in preparation of a medicine for treating type II diabetes and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The ginseng GUBEN preparation is mainly prepared from ginseng, rehmannia root, prepared rehmannia root, asparagus cochinchinensis, Radix Ophiopogonis, dogwood, Chinese yam, rhizoma alismatis, moutan bark and poria cocos. The invention further researches and develops the new application of the ginseng GUBEN oral liquid in the market. Pharmacodynamic research results show that the ginseng GUBEN preparation can improve polydipsia, polyphagia and diuresis conditions of diabetic mice, significantly reduce blood sugar of the diabetic mice, improve oral glucose tolerance, and reduce triglyceride, cholesterol and glycosylated hemoglobin levels in serum, has an exact treatment effect on type II diabetes. Wide popularization and application prospects are realized.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition, in particular to the application of a ginseng solidifying preparation in the preparation of medicines for treating type II diabetes, and belongs to the technical field of traditional Chinese medicines. [0002] technical background [0003] Diabetes Mellitus (DM) is a metabolic disease of multiple etiologies characterized by hyperglycemia. Modern medicine believes that DM is caused by defects in insulin secretion or its biological effects, or both. Traditional Chinese medicine believes that the pathogenesis of diabetes includes deficiency of yin and hyperactivity of fire, deficiency of both qi and yin, deficiency of both yin and yang, deficiency of the spleen and excessive dampness, and obstruction of collaterals by blood addiction. The typical symptoms of diabetes are "three excesses and one deficiency", that is, drinking more water, eating more, urinating more a...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61P3/10
CPCA61K36/258A61K36/804A61K36/8965A61K36/8968A61K36/40A61K36/8945A61K36/884A61K36/71A61K36/65A61K36/076A61K9/0053A61P3/10A61K2236/331A61K2236/333A61K2300/00
Inventor 毕艳艳杜昊忱
Owner LUNAN PHARMA GROUP CORPORATION
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