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Sustained release tablet for diabetes and its preparation method

A technology for sustained-release tablets and diabetes, which is applied in the field of sustained-release tablets for diabetes and its preparation, and achieves the effects of restoring islet function, good curative effect and high bioavailability.

Inactive Publication Date: 2018-05-25
GUANGXI WANDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to the present invention, there are no reports on the compositions of Argonaut chinensis, Gymnema sylvestris, Gymnema sylvestris, Lily chrysanthemum, Purslane, and Sagevine composition

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation method of the sustained-release tablet for diabetes is characterized in that it comprises the following steps:

[0033] S1: Weigh by weight: Gymnema 30kg, Gymnema 10kg, Gymnema vine 10kg, Lily chrysanthemum 10kg, Purslane 20kg, Sage vine 10kg;

[0034] S2: add 6 times the amount of water, decoct and extract 2 times, 3 hours each time, and filter, combined filtrate;

[0035] S3: Concentrate the combined filtrate in vacuum to a thick paste with a relative density of 1.20 at 60°C, add starch and sodium carboxymethylcellulose, mix well, granulate, dry, add 8 kg of hydroxypropylmethylcellulose, poly Vinylpyrrolidone 1.5kg, methyl cellulose 10kg, magnesium stearate 0.3kg, compressed into tablets to make sustained-release tablets.

Embodiment 2

[0037] The preparation method of the sustained-release tablet for diabetes is characterized in that it comprises the following steps:

[0038] S1: Weigh by weight: Gymnema 60kg, Gymnema 30kg, Gymnema syringae 20kg, Lily chinensis 30kg, Purslane 50kg, Sagevine 20kg;

[0039] S2: Add 10 times the amount of water, decoct and extract 3 times, 1 hour each time, and filter, combined filtrate;

[0040] S3: Concentrate the combined filtrate in vacuum to a thick paste with a relative density of 1.30 at 65°C, add starch and sodium carboxymethylcellulose, mix well, granulate, dry, add 12kg of hydroxypropylmethylcellulose, poly Vinylpyrrolidone 2.0kg, methylcellulose 15kg, magnesium stearate 0.6kg, compressed into tablets, made into sustained-release tablets.

Embodiment 3

[0042] The preparation method of the sustained-release tablet for diabetes is characterized in that it comprises the following steps:

[0043] S1: Weigh by weight: Gymnema 40kg, Gymnema 20kg, Gymnema syringae 15kg, Lily chrysanthemum 20kg, Purslane 30kg, Sagevine 15kg;

[0044] S2: Add 8 times the amount of water to the weighed Gymnema chinensis, Gymnema sylvestris, Gymnema sylvestris vine, Chrysanthemum chinensis, purslane, and Sageteng vine, decoct and extract 3 times for 2 hours each time, filter, combined filtrate;

[0045] S3: Concentrate the combined filtrate in vacuum to a thick paste with a relative density of 1.25 at 63°C, add starch and sodium carboxymethylcellulose, mix well, granulate, dry, add 10kg of hydroxypropylmethylcellulose, poly Vinylpyrrolidone 1.8kg, methylcellulose 12kg, magnesium stearate 0.5kg, compressed into tablets to make sustained-release tablets.

[0046] 2. Clinical application

[0047] The slow-release tablet used for diabetes of the present i...

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PUM

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Abstract

The invention discloses a sustained release tablet for diabetes and its preparation method. The raw material is prepared from, by weight, 30-60 parts of rhizoma dioscoreae tokoro, 10-30 parts of gymnema sylvestre schult, 10-20 parts of Cuscuta chlnensls Lain, 10-30 parts of Polygala aureocauda Dunn, 20-50 parts of herba portulacae, 10-20 parts of Kadsura Longipedunculata. The sustained release tablet is strict in formula and has the effects of clearing heat and promoting diuresis, cooling blood, and replenishing qi to invigorate the spleen, and also obviously improving diabetes symptoms such as polydipsia, diuresis, polyphagia, emaciation, fatigue and lack of strength, and weakness of the spleen and the stomach; the tablet further repairs the pancreas islet function; the drug release is slow and durable, the bioavailability is high, no bad reaction happens; therefore, the sustained release tablet has good treatment effect to diabetes.

Description

technical field [0001] The invention belongs to the field of medicines, and relates to a slow-release tablet for diabetes and a preparation method thereof. Background technique [0002] Diabetes belongs to the category of quenching thirst in traditional Chinese medicine. Diabetes is a disease characterized by polydipsia, polyphagia, polyuria, and body weight loss. The name of quenching thirst first appeared in the "Huangdi Neijing", and in "Synopsis of the Golden Chamber", it divides quenching thirst into three types: those who are thirsty and drink a lot are called upper Xiao; those who eliminate grains and are hungry are called middle Xiao; Those who are like ointment will disappear. [0003] Traditional Chinese medicine believes that factors such as improper diet, emotional disorders, excessive labor desire, and weak body can lead to thirst. The pathogenesis of the disease is characterized by yin deficiency and dryness, which is based on yin deficiency and marked by dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/22A61K47/38A61P3/10
CPCA61K9/2054A61K36/185A61K36/27A61K36/54A61K36/57A61K36/69A61K36/79A61K36/8945A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 廖厚知杨坤李家宝
Owner GUANGXI WANDE PHARMA
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