Microneedle paster for replenishing water and dispelling wrinkles and preparation method of microneedle paster

A micro-needle patch and moisturizing technology, applied in the field of skin care products, can solve the problems of discount in beauty effect, easy to cause allergies, inaccuracy, etc., and achieve the effect of excellent application development prospects.

Inactive Publication Date: 2019-05-03
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main defect of most moisturizing and anti-wrinkle skin care products is that the effect is slow and inaccurate, and it is easy to cause skin problems such as allergies
On the other hand, due to the obstruction of the stratum corneum of the skin, skin care products that are only applied on the skin surface are difficult to be truly absorbed, and the cosmetic effect is also greatly reduced.

Method used

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  • Microneedle paster for replenishing water and dispelling wrinkles and preparation method of microneedle paster
  • Microneedle paster for replenishing water and dispelling wrinkles and preparation method of microneedle paster
  • Microneedle paster for replenishing water and dispelling wrinkles and preparation method of microneedle paster

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Preparation of epoxy resin microneedle template

[0024] Fabrication of microneedle templates with a height of 500μm, a bottom diameter of 500μm, a pitch of 1800μm, and a 10×14 array. Proceed as follows:

[0025] 1) Mix epoxy resin A glue and epoxy resin B glue according to the mass ratio of 3:1 (or volume ratio of 2.5:1), stir until the glue is completely transparent without drawing inside, and cure for 90 minutes at 50℃ to make it Into the curing stage, a semi-cured epoxy resin film is obtained.

[0026] 2) Place the prepared metal microneedles on the semi-cured epoxy resin film, press uniformly, and place them at room temperature for 5 hours to obtain a microneedle template with uniform thickness.

[0027] 3) Measure the thickness of the obtained microneedle template, place it in a package at room temperature, and mark the microneedle size parameters.

[0028] The parameters of the microneedle template in this embodiment are 500±10 μm in height, 500±10 μm in bottom...

Embodiment 2

[0029] Example 2 Sample solution preparation

[0030] The preparation of hyaluronic acid P-WH active peptide mixture is as follows:

[0031] 1) Choose hyaluronic acid with molecular weights of 10kDa, 100kDa and 400kDa, add ultrapure water to prepare 10%, 5%, 2% hyaluronic acid solution, stir it and let it stand for more than 2h, and place it Refrigerate at 4°C and let it stand overnight to make it fully swell to a gelatinous state by absorbing water, and set aside.

[0032] 2) Weigh 4mg of active peptide P-WH, dissolve it in 4ml ultrapure water to prepare a drug concentration of 1mg / ml, and then dilute it to 800μg / ml, 200μg / ml, 100μg / ml. spare.

[0033] 3) Weigh 2mg of FITC-P-WH (FITC fluorescent label labeled active peptide P-WH), dissolve it in 2ml of dimethyl sulfoxide DMSO, and prepare a FITC-P-WH solution with a concentration of 1mg / ml. Dilute it to a concentration of 800μg / ml, 200μg / ml, and 100μg / ml for use.

[0034] 4) Mix the P-WH active peptide solution and FITC-P-WH solutio...

Embodiment 3

[0035] Example 3 Preparation of Hyaluronic Acid Soluble Empty Microneedles

[0036] The preparation of hyaluronic acid soluble microneedles is as follows:

[0037] 1) Put the hyaluronic acid solution prepared in Example 2 at room temperature for more than 10 minutes.

[0038] 2) At room temperature, add 1ml of hyaluronic acid solutions with molecular weights of 10kDa, 100kDa, and 400kDa and concentrations of 10%, 5%, and 2% respectively (according to the drug loading, template area and required microneedle patch Thickness, the number of times of dropping the solution can be adjusted) On the mold cavity of the clean epoxy resin microneedle template, ensure that the hyaluronic acid solution completely covers the mold cavity, and vacuum treatment for 10 minutes.

[0039] 3) Place the microneedle template in a ventilated place to air dry, demold and dry, and store it at 4°C for later use after sealing.

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Abstract

The invention relates to microneedle paster for replenishing water and dispelling wrinkles and a preparation method of the microneedle paster, and relates to the field of skin-care products. The microneedle paster comprises a base and a microneedle, wherein a plurality of needles are uniformly distributed on the base; the base and the needles are made from main body support components, and functional components are dispersed in the main body support components; and the main body support components are hyaluronic acid, and the functional components are bioactive peptide P-WH. The microneedle paster disclosed by the invention can effectively penetrate through stratum corneum to dissolve by tissue liquid of a cuticular layer and epidermis, P-WH is released to cuticle and dermal tissue to diffuse so as to stimulate secretion of skin cell collagen, and the effects of preventing and repairing skin ageing and rough skin, replenishing water and resisting ageing can be achieved.

Description

Technical field [0001] The invention belongs to the field of skin care products, and relates to a microneedle patch for hydrating and wrinkle removal and a preparation method thereof. Background technique [0002] The pursuit of beauty and the pursuit of reversing the effects of aging can be traced back to centuries ago. As people grow older, they will inevitably be accompanied by irreversible physiological aging. The most common manifestation is the relaxation of facial tissues. And wrinkles. Some skin care products add vitamins to prevent and improve skin dryness and aging. For example, vitamin B3 in the form of niacinamide and nicotinate can be used as a precursor of endogenous enzyme cofactors with antioxidant function and used in skin care. In products, niacinamide and nicotinic acid ester are used as cosmetic formulations, and their hydrolyzed niacin can also induce strong skin redness at low doses; vitamin E, which is also a typical antioxidant, can reduce sunburn after u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/64A61K8/02A61Q19/00A61Q19/08A61M37/00
Inventor 于海宁王梦可
Owner DALIAN UNIV OF TECH
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