Production method of ethylene diaminetetraacetic acid ferric sodium salt

A technology of ferric sodium edetate and tetrasodium edetate, which is applied in the field of biology and new medicine, can solve the problems of reducing product purity, difficult separation of by-products, and difficulty in mother liquor recycling, so as to reduce raw material consumption and waste, to achieve the effect of material and liquid recycling

Active Publication Date: 2019-04-19
北京海德恒生科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But the preparation method of above-mentioned sodium ferric edetate is on the one hand, when adopting iron trichloride or ferric sulfate to be raw material to prepare directly in the technique, will contain inorganic salt by-products such as a large amount of sodium chloride, sodium sulfate in the product, follow-up separation Difficult to increase the cost of industrial production; on the other hand, when disodium ethylenediaminetetraacetic acid is used as a raw material in the process, there will also be a large amount of sodium ions in the product, reducing the purity of the product
[0006] From above-mentioned prior art, can obviously find, utilize ferric chloride / iron sulfate with strong water solubility and EDTA or its sodium salt reaction to prepare sodium ferric edetate and can generate by-product sodium chloride / sodium sulfate, and By-products are not easy to separate, resulting in low product purity and difficulty in mother liquor recycling

Method used

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  • Production method of ethylene diaminetetraacetic acid ferric sodium salt

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A kind of production method of ferric sodium edetate, such as figure 1 shown, including the following steps:

[0042] S1. Preliminary reaction: Add ferric chloride, tetrasodium ethylenediaminetetraacetic acid and water into the reactor at a molar ratio of 1:1:25, react for 1 hour, and the reaction is completed to obtain the raw material solution, and then the raw material solution is mixed at 10 Cooling and crystallization at a temperature of ℃ for 1.5h. The cooling and crystallization process can be realized in a cooling crystallizer. After the crystallization is completed, the first separation operation is performed to obtain feed liquid A and solid product B. In this step, the first separation operation can be a filtration operation, or It can be a centrifugal separation operation;

[0043]Specifically, when the first separation operation is a filtration operation, the raw material liquid after cooling and crystallization is filtered in a filter with a mesh size of ...

Embodiment 2

[0054] A kind of production method of ferric sodium ethylenediamine tetraacetate, carry out difference according to the method in embodiment 1 and be,

[0055] S1. Preliminary reaction: Add ferric chloride, tetrasodium ethylenediaminetetraacetic acid and water into the reactor at a molar ratio of 1:1.5:30, react for 100 minutes, and obtain the raw material liquid after the reaction is completed, and then put the raw material liquid at 18 Cool and crystallize at a temperature of 105min for 105min. The cooling crystallization process can be realized in a cooling crystallizer. After the crystallization is completed, the first separation operation is performed to obtain feed liquid A and solid product B. The first separation operation here can be a filtration operation or is a centrifugal separation operation;

[0056] S2, including solid product B processing S2-1 and feed liquid A processing S2-2, step S2-1 operates solid product B to obtain the desired final product sodium ferri...

Embodiment 3

[0064] A kind of production method of ferric sodium ethylenediamine tetraacetate, carry out difference according to the method in embodiment 1 and be,

[0065] S1. Preliminary reaction: Add ferric chloride, tetrasodium ethylenediaminetetraacetic acid and water into the reactor at a molar ratio of 1:2:35, react for 2 hours, and the reaction is completed to obtain the raw material solution, and then put the raw material solution at 25 Cooling and crystallization at a temperature of °C for 2 hours, the cooling crystallization process can be realized in a cooling crystallizer, and the first separation operation is performed after the crystallization is completed to obtain the feed liquid A and the solid product B. The first separation operation here can be a filtration operation or is a centrifugal separation operation;

[0066] S2, including solid product B processing S2-1 and feed liquid A processing S2-2, step S2-1 operates solid product B to obtain the desired final product so...

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Abstract

The invention discloses a production method of ethylene diaminetetraacetic acid ferric sodium salt. The production method comprises the following steps that a primary reaction is carried out, whereinferric trichloride reacts with ethylene diaminetetraacetic acid tetrasodium salt in water to obtain a stock solution A and a solid product B; the solid product B is dried to prepare the ethylene diaminetetraacetic acid ferric sodium salt; the stock solution A is subjected to chromatographic treatment to obtain a component A-1 containing sodium chloride NaCl and a component A-2 containing the ethylene diaminetetraacetic acid tetrasodium salt; the component A-1 is crystallized and separated to obtain NaCl solid C and NaCl filtrate D, the NaCl solid C is dried to prepare byproduct solid NaCl, andthe NaCl filtrate D is subjected to the operation in the filtrate treatment step again; the component A-2 containing the ethylene diaminetetraacetic acid tetrasodium salt is subjected to the primaryreaction again. The method has the advantages that the ethylene diaminetetraacetic acid ferric sodium salt and sodium chloride in reaction liquid can be separated, the separated component containing the ethylene diaminetetraacetic acid ferric sodium salt can serve as the reaction liquid to participate in the reaction as the raw material again; meanwhile, the byproduct sodium chloride is obtained and utilized.

Description

technical field [0001] The invention relates to the technical field of biology and new medicine, more specifically, it relates to a production method of sodium ferric ethylenediaminetetraacetate. Background technique [0002] Sodium iron ethylenediaminetetraacetate (NaFeEDTA) is a chelated iron nutritional supplement. In recent years, it has been widely used in flour and its products, solid beverages, etc. , condiments, biscuits, dairy products and health food, it has a good effect on improving iron deficiency anemia in large population. [0003] Traditional food-grade sodium ferric EDTA is produced by ferric chloride and disodium EDTA, but this production method will produce sodium chloride as a by-product, and the mother liquor needs to be discarded after being circulated several times. [0004] Another example is that the Chinese patent application publication number CN106866441A discloses a preparation method of high-purity sodium ferric ethylenediamine tetraacetate. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/18C07C227/40C07C227/42C07C229/76C01D3/04
CPCC01D3/04C07C227/18C07C227/40C07C227/42C07C229/76
Inventor 许中敏刘斌斌侯晟
Owner 北京海德恒生科技发展有限公司
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