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A kind of analysis method of compatibility between midazolam and production system

A midazolam and analysis method technology, applied in the field of analysis and detection, can solve the problems of uneven digestion, large error, small sampling amount and the like

Active Publication Date: 2022-01-25
上海微谱检测科技集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently limited by the sample processing method and detection conditions, the sample volume of the sample to be tested is usually relatively small when performing element determination, which leads to a very low detection value of the sample during the determination process, and some components are difficult to detect or the measurement error is large.
However, when the sampling volume of the sample to be tested is increased, problems such as gelatinization, uneven digestion or insufficient digestion often occur in the sample during the digestion process, resulting in difficult or large errors in the measurement
Moreover, currently known digestion methods for samples, such as microwave digestion, ashing digestion, acid digestion, etc., in which ashing digestion has low efficiency and poor precision, often leads to the volatilization of the elements to be measured (such as Pb, Hg, As)
Although microwave digestion is convenient, the cost is too high, the sample volume is small, there are potential safety hazards, and the range of elements that can be determined is small
The most widely used is acid digestion, but the biggest problem with traditional acid digestion is that the digestion is not complete, and the excess acid remaining in the digestion solution will affect the measurement results. Therefore, a new type of midazolam and production system needs to be developed in this field Analytical method of compatibility

Method used

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  • A kind of analysis method of compatibility between midazolam and production system
  • A kind of analysis method of compatibility between midazolam and production system
  • A kind of analysis method of compatibility between midazolam and production system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1 provides a kind of midazolam and the analysis method of production system compatibility, comprises the following steps:

[0055] S1: Preparation of sample master solution

[0056] Weigh 2g of midazolam, add 28mL of 1wt% dilute hydrochloric acid, concentrated nitric acid, 30wt% hydrogen peroxide in a weight ratio of 7:4:1, stir and dissolve; weigh 16g of sodium chloride, dissolve it with 1600mL of water Blank solution; add midazolam solution to the blank solution, add 5wt% diisopropylamine to it, stir well, adjust pH to 3.3 with 1% dilute hydrochloric acid solution or 0.02M sodium hydroxide solution, add water to the mark.

[0057] S2: Preparation of sample solution

[0058] Take 5mL of sample mother solution in a 50mL measuring bottle, dilute to the mark with diluent 2% nitric acid, and shake well.

[0059] S3: Preparation of blank solution

[0060] Take 5mL of water in a 50mL volumetric flask, dilute to the mark with diluent, and shake well.

[0061] S...

Embodiment 2

[0070] Embodiment 2 provides a kind of midazolam and the analysis method of production system compatibility, comprises the following steps:

[0071] S1: Preparation of sample master solution

[0072] Weigh 2g of midazolam, add 28mL of 1wt% dilute hydrochloric acid, concentrated nitric acid, 30wt% hydrogen peroxide in a weight ratio of 7:4:1, stir and dissolve; weigh 16g of sodium chloride, dissolve it with 1600mL of water Blank solution; add midazolam solution to the blank solution, add 1wt% diisopropylamine to it, stir well, adjust pH to 3.2 with 1% dilute hydrochloric acid solution or 0.02M sodium hydroxide solution, add water to the mark.

[0073] S2: Preparation of sample solution

[0074] Take 5mL of sample mother solution in a 50mL measuring bottle, dilute to the mark with diluent 2% nitric acid, and shake well.

[0075] S3: Preparation of blank solution

[0076] Take 5mL of water in a 50mL volumetric flask, dilute to the mark with diluent, and shake well.

[0077] S...

Embodiment 3

[0086] Embodiment 3 provides a kind of midazolam and the analysis method of production system compatibility, comprises the following steps:

[0087] S1: Preparation of sample master solution

[0088] Weigh 2g of midazolam, add 28mL of 1wt% dilute hydrochloric acid, concentrated nitric acid, 30wt% hydrogen peroxide in a weight ratio of 7:4:1, stir and dissolve; weigh 16g of sodium chloride, dissolve it with 1600mL of water Blank solution: add the midazolam solution to the blank solution, add 10wt% diisopropylamine thereinto, stir evenly, adjust the pH to 3.4 with 1% dilute hydrochloric acid solution or 0.02M sodium hydroxide solution, and add water to the mark.

[0089] S2: Preparation of sample solution

[0090] Take 5mL of sample mother solution in a 50mL measuring bottle, dilute to the mark with diluent 2% nitric acid, and shake well.

[0091] S3: Preparation of blank solution

[0092] Take 5mL of water in a 50mL volumetric flask, dilute to the mark with diluent, and shake ...

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Abstract

The invention provides a method for analyzing the compatibility between midazolam and a production system, comprising the following steps: S1: preparation of a sample mother liquor, dissolving midazolam and a mixed solution in a sodium chloride solution, and adjusting the pH to 3-4, add water to make up to the scale; S2: ICP-MS test, the mixed solution contains at least one of dilute hydrochloric acid, concentrated nitric acid, and hydrogen peroxide; the detection method provided by the present invention can accurately detect metal ions , and will not be interfered by C and F ions.

Description

technical field [0001] The invention relates to the field of analysis and detection, in particular to an analysis method for compatibility between midazolam and a production system. Background technique [0002] The chemical name of midazolam is 1-methyl-8-chloro-6-(2-fluorophenyl)-4H-imidazo[l,5-a][l,4]benzodiazepine , the drug has the typical benzodiazepine Pharmacological activity, can produce anxiolytic, sedative, hypnotic, anticonvulsant and muscle relaxation effects. After intramuscular or intravenous administration, transient anterograde amnesia can occur, making patients unable to recall events that occurred during the peak period of the drug. The drug is characterized by rapid onset and short duration of action. After taking the medicine, it can shorten the time to fall asleep and prolong the total sleep time, but has no effect on fast wave sleep. After waking up in the next morning, the patient can feel energetic, relaxed and happy. No tolerance and withdrawa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/626G01N1/28G01N1/38
CPCG01N1/28G01N1/38G01N27/62G01N2001/2893
Inventor 吴杰贾梦虹秦秋明杨潇军
Owner 上海微谱检测科技集团股份有限公司
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