Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Preparation method for carbazolyl isopropanolamine derivative and application thereof

A technology of carbazolyl isopropanolamine and alkyl, which is applied in the field of preparation of carbazolyl isopropanolamine derivatives, and can solve the problems of environmental pollution, poor prevention effect and high toxicity

Active Publication Date: 2019-04-16
GUIZHOU UNIV
View PDF2 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing commercialized antimicrobial agents (such as eclopyrazole, thiazocopper, and ketal) not only have problems such as poor control effect, high toxicity, and serious environmental pollution, but also increase the drug resistance of pathogens. It is urgent to find highly effective antibacterial agents Active compounds of pathogenic bacteria, on this basis, create green new pesticides with independent intellectual property rights, and provide candidate drugs for the prevention and control of bacterial diseases of crops

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method for carbazolyl isopropanolamine derivative and application thereof
  • Preparation method for carbazolyl isopropanolamine derivative and application thereof
  • Preparation method for carbazolyl isopropanolamine derivative and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1: Preparation of 1-(benzylamino)-3-(9H-carbazolyl)-2-hydroxypropanol

[0053] Add 9-(2-methyloxyethylene)-9H-carbazole (0.90mmol) and potassium carbonate (0.90mmol) into 5mL isopropanol solution dissolved with benzylamine (1.80mmol), and react at 60°C for 6 hours After stopping the reaction, desolvation, column chromatography (eluent CH 2 Cl 2 :CH 3 OH=200:1) to obtain a white solid with a yield of 53.7%.

[0054] The structures, H-NMR and C-NMR data of some synthesized compounds containing carbazolyl isopropanolamine structures are shown in Table 1, and their physical and chemical properties are shown in Table 2.

[0055] H NMR spectrum and carbon spectrum data of some compounds in Table 1

[0056]

[0057]

[0058]

[0059] Table 2 Physicochemical properties of some target compounds

[0060]

[0061]

[0062] Pharmacological Example 1:

[0063] The inhibitory rate of the target compounds to plant pathogenic bacteria was tested by turbidim...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparation method for carbazolyl isopropanolamine derivative and application thereof. The structure of the compound is shown in the formula (I), and the compound achieves the better effect of inhibiting xanthomonas oryzae, ralstonia solanacearum, cucumber xanthomonas oryzae, konjak xanthomonas oryzae, xanthomonas citri, grape ulcer bacteria, tomato ulcer bacteria, kiwifruit ulcer bacteria, apple ulcer bacteria, cucumber botrytis cinerea, chili blight bacteria, sclerotinia sclerotiorum, wheat gibberella saubinetii, potato late blight, blueberry root rotting bacteriaand the like.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to a preparation method and application of a class of carbazolyl isopropanolamine derivatives. Background technique [0002] Plant-borne bacterial diseases are one of the most destructive plant diseases in the world, and even cause crop failure in severe cases, causing great harm to crops and economic crops in our country. Among them, bacterial diseases such as rice bacterial blight (Xanthomonas oryzae pv.oryzae, Xoo) and citrus canker (Xanthomonas axonopodispv.citri, Xac) cause losses of hundreds of millions of dollars to agriculture every year. Existing commercialized antimicrobial agents (such as eclopyrazole, thiazocopper, and ketal) not only have problems such as poor control effect, high toxicity, and serious environmental pollution, but also increase the drug resistance of pathogens. It is urgent to find highly effective antibacterial agents Active compounds of p...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D209/86C07D405/12C07D409/12A01N43/38A01P1/00A01P3/00
CPCA01N43/38C07D209/86C07D405/12C07D409/12
Inventor 杨松赵永亮王培义黄星龙青素吴元元薛伟
Owner GUIZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com