Preparation method of active composition for targeted treatment of avian influenza

A technology for targeted therapy and avian influenza, which can be applied to medical preparations containing active ingredients, pharmaceutical formulations, and plant raw materials, etc., can solve the problems of high morbidity and mortality, economic losses in the poultry industry, and large side effects of drugs, etc. Achieve the effect of avoiding pollution, reliable efficacy, and no drug resistance

Inactive Publication Date: 2019-04-16
孟繁华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After the poultry is infected with the avian influenza virus, it usually takes 3-5 days to become ill, and the morbidity and mortality are very high, up to 100%, causing huge economic losses to the poultry industry
[0003] At this stage, there are many types of drugs against avian influenza virus infection in poultry, but some effective drugs have developed drug resistance, which is very unfavorable for the treatment of avian influenza, or some drugs have relatively large side effects and poor therapeutic effect

Method used

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  • Preparation method of active composition for targeted treatment of avian influenza
  • Preparation method of active composition for targeted treatment of avian influenza
  • Preparation method of active composition for targeted treatment of avian influenza

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] This embodiment provides a method for preparing an active composition for targeted treatment of avian influenza, comprising the following steps:

[0047] (1) Take 10kg of honeysuckle, 9kg of rhodiola, 10kg of repentant grass, 8kg of Gynostemma pentaphyllum, 10kg of fennel, 8kg of mignonette, 9kg of garcinia, 9kg of scutellaria, 7kg of cordyceps, 10kg of white flower, and 10kg of Scutellaria barbata, and wash them in turn, Dried, pulverized to 150 mesh, and mixed to obtain pulverized raw materials;

[0048] (2) Add 8 times the mass of water to the pulverized raw material, decoct with a slow fire for 1.5 hours, filter to obtain the traditional Chinese medicine filtrate;

[0049] (3) using ammonium sulfate and glucose to adjust the carbon-to-nitrogen ratio of the traditional Chinese medicine filtrate to 25:1 to obtain the adjusted filtrate;

[0050] (4) Take the adjusted filtrate, glucose, dipotassium hydrogen phosphate, magnesium sulfate, yeast extract, vitamin B1, vitam...

Embodiment 2

[0054] This embodiment provides a method for preparing an active composition for targeted treatment of avian influenza, comprising the following steps:

[0055] (1) Take 10kg of honeysuckle, 9kg of rhodiola, 10kg of repentant grass, 8kg of Gynostemma pentaphyllum, 10kg of fennel, 8kg of mignonette, 9kg of garcinia, 9kg of scutellaria, 7kg of cordyceps, 10kg of white flower, and 10kg of Scutellaria barbata, and wash them in turn, Dried, crushed to 250 mesh, and mixed to obtain crushed raw materials;

[0056] (2) Add 12 times the mass of water to the pulverized raw material, decoct with a slow fire for 2.5 hours, and filter to obtain the traditional Chinese medicine filtrate;

[0057] (3) using ammonium sulfate and glucose to adjust the carbon-to-nitrogen ratio of the traditional Chinese medicine filtrate to 29:1 to obtain the adjusted filtrate;

[0058] (4) Take the adjusted filtrate, sucrose, sodium nitrate, magnesium sulfate, potassium chloride, potassium dihydrogen phosphat...

Embodiment 3

[0062] This embodiment provides a method for preparing an active composition for targeted treatment of avian influenza, comprising the following steps:

[0063] (1) Take 10kg of honeysuckle, 9kg of rhodiola, 10kg of repentant grass, 8kg of Gynostemma pentaphyllum, 10kg of fennel, 8kg of mignonette, 9kg of garcinia, 9kg of scutellaria, 7kg of cordyceps, 10kg of white flower, and 10kg of Scutellaria barbata, and wash them in turn, Drying, pulverizing to 200 mesh, and mixing to obtain pulverized raw materials;

[0064] (2) Add 10 times the mass of water to the pulverized raw material, decoct with a slow fire for 2 hours, and filter to obtain the traditional Chinese medicine filtrate;

[0065] (3) using ammonium sulfate and glucose to adjust the carbon-to-nitrogen ratio of the traditional Chinese medicine filtrate to 27:1 to obtain the adjusted filtrate;

[0066] (4) Take the adjusted filtrate, glucose, dipotassium hydrogen phosphate, magnesium sulfate, yeast extract, vitamin B ...

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Abstract

The invention relates to a preparation method of an active composition for targeted treatment of avian influenza. The preparation method specifically includes first pulverizing, decocting, filtering and adjusting the carbon nitrogen ratio of traditional Chinese medicine ingredients including honeysuckle, rhodiola, hempleaf groundsel herb, gynostemma, mosla chinensis maxim, mignonette, gamboge, scutellaria baicalensis, cordyceps sinensis, solanum lyratum and scutellaria barbata to obtain an adjusted filtrate; preparing the adjusted filtrate into a medium, utilizing stems and leaves of the abovetraditional Chinese medicine except the gamboges and the cordyceps sinensis as substances to be cultured, culturing the substances to be cultured in the medium, and conducting expansion culture and pharmacodynamic screening sequentially to obtain the active composition. The active composition is obtained by means of biological processing fermentation, and avoids pollution caused by using chemicalmethods. The active composition can be targeted to the avian influenza virus without causing drug tolerance, and is reliable in drug effect and free of toxic or side effects.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine application, and in particular relates to a preparation method of an active composition for targeted treatment of avian influenza. Background technique [0002] Avian influenza, the full name of which is avian influenza, is an acute infectious disease caused by avian influenza virus. It generally only spreads among birds, rarely infects pigs, and rarely infects humans across the species barrier. Poultry infected with avian influenza virus will mainly have systemic or respiratory diseases. Poultry such as chickens, turkeys, ducks, and quails, as well as wild birds such as wild birds, waterfowl, and seabirds, can be infected. The incidence ranges from acute septicemia to asymptomatic Carriers are extremely diverse, mainly depending on the resistance of the carrier and the type and virulence of the infected virus. The avian influenza virus is mainly transmitted among poultry through air, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61P31/16
CPCA61P31/16A61K36/068A61K36/185A61K36/28A61K36/355A61K36/38A61K36/41A61K36/424A61K36/53A61K36/539A61K36/81A61K2236/19A61K2236/331A61K2300/00
Inventor 孟繁华
Owner 孟繁华
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