Application of p-hydroxybenzoic acid in preparing drug for treating inflammatory bowel disease

A technology of p-hydroxybenzoic acid and inflammatory bowel disease, which is applied in the application field of p-hydroxybenzoic acid in the preparation of drugs for treating inflammatory bowel disease, and can solve the problems of many adverse reactions, high price, and unsuitable for long-term medication

Active Publication Date: 2019-04-16
GUILIN MEDICAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs mainly suppress the abnormal immune response, reduce the local inflammation of the colon, and prevent the progression of the disease, but they have the disadvantages of unstable curative effect, many adverse reactions, poor tolerance, unsuitable for long-term medication or expensive.

Method used

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  • Application of p-hydroxybenzoic acid in preparing drug for treating inflammatory bowel disease
  • Application of p-hydroxybenzoic acid in preparing drug for treating inflammatory bowel disease
  • Application of p-hydroxybenzoic acid in preparing drug for treating inflammatory bowel disease

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Experimental program
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Effect test

Embodiment Construction

[0015] The technical solution of the present invention will be further described below in conjunction with specific embodiments.

[0016] In the animal experiment, 2.5% dextran sulfate sodium (dextran sulfate sodium, DSS) solution was used to induce C57BL / 6 mice to build a UC model, and the model mice were given p-hydroxybenzoic acid and the positive drug mesalamine by intragastric administration, and the p-hydroxybenzoic acid was analyzed. Improvement effect on UC.

[0017] 1. Materials

[0018] 1.1 Experimental animals

[0019] SPF grade C57BL / 6 mice, female, 6-8 weeks old, weighing 20±2g, purchased from Hunan Slake Jingda Experimental Animal Co., Ltd., license number: SCXK (Xiang) 2016-0002, certificate number: SYXK (Gui) 2013-0001. They were raised in an environment with a temperature of 25±2°C and a relative humidity of 55±10%, with free access to food and water. Use after one week of adaptation.

[0020] 1.2 Experimental reagents

[0021] p-Hydroxybenzoic acid; Mes...

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Abstract

The invention discloses application of p-hydroxybenzoic acid in preparing a drug for treating an inflammatory bowel disease. At a dose significantly lower than mesalazine, the p-hydroxybenzoic acid can significantly inhibit the increase in disease activity index scores of enteritis model mice induced by dextran sodium sulfate, improve colon length shortening of the colitis model mice, reduce the colonic MPO activity of the mice, and reduce the inflammatory cell infiltration of colon tissues in the colitis model mice. According to the application, the p-hydroxybenzoic acid can alleviate the inflammatory reaction of the DSS-induced inflammatory bowel disease model mice and improve the severity of the inflammatory bowel disease, and can be used for preparing the drug or a health care productfor treating the inflammatory bowel disease.

Description

technical field [0001] The invention relates to the application of p-hydroxybenzoic acid, in particular to the application of p-hydroxybenzoic acid in preparing medicine for treating inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease that mainly involves the ileum, rectum, and colon. The clinical manifestations are diarrhea, abdominal pain, and even bloody stool. Inflammatory bowel diseases include ulcerative colitis (UC) and Crohn's disease (CD). Ulcerative colitis is a continuous inflammation of the colonic mucosa and submucosa. The disease usually involves the rectum first and gradually spreads to the entire colon. Crohn's disease is a discontinuous full-thickness inflammation that can involve the entire digestive tract. Terminal ileum, colon and perianal area. As a typical inflammatory bowel disease, UC occurs in young adults aged 30-40, and there is no gender difference. It is man...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P1/00A61P1/04A23L33/10
CPCA23V2002/00A61K31/192A23L33/10A61P1/00A61P1/04A23V2200/32A23V2250/02
Inventor 段小群徐笑天王宇晖
Owner GUILIN MEDICAL UNIVERSITY
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