Application of p-hydroxybenzoic acid in preparing drug for treating inflammatory bowel disease
A technology of p-hydroxybenzoic acid and inflammatory bowel disease, which is applied in the application field of p-hydroxybenzoic acid in the preparation of drugs for treating inflammatory bowel disease, and can solve the problems of many adverse reactions, high price, and unsuitable for long-term medication
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[0015] The technical solution of the present invention will be further described below in conjunction with specific embodiments.
[0016] In the animal experiment, 2.5% dextran sulfate sodium (dextran sulfate sodium, DSS) solution was used to induce C57BL / 6 mice to build a UC model, and the model mice were given p-hydroxybenzoic acid and the positive drug mesalamine by intragastric administration, and the p-hydroxybenzoic acid was analyzed. Improvement effect on UC.
[0017] 1. Materials
[0018] 1.1 Experimental animals
[0019] SPF grade C57BL / 6 mice, female, 6-8 weeks old, weighing 20±2g, purchased from Hunan Slake Jingda Experimental Animal Co., Ltd., license number: SCXK (Xiang) 2016-0002, certificate number: SYXK (Gui) 2013-0001. They were raised in an environment with a temperature of 25±2°C and a relative humidity of 55±10%, with free access to food and water. Use after one week of adaptation.
[0020] 1.2 Experimental reagents
[0021] p-Hydroxybenzoic acid; Mes...
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