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Specific cancer coregulatory network establishment method and device

A technology for establishing a method and regulating network, which is applied in the field of establishing a cancer-specific co-modulation network, can solve the problems of lack of gene expression data combination, accuracy needs to be improved, etc., and achieve the effect of improving accuracy

Active Publication Date: 2019-04-12
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing research on the co-regulation relationship between miRNA-TF lacks specific analysis of diseases (such as cancer), and lacks the combination with gene expression data. The accuracy of the conclusion on the co-regulation relationship between miRNA-TF needs to be improved

Method used

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  • Specific cancer coregulatory network establishment method and device
  • Specific cancer coregulatory network establishment method and device
  • Specific cancer coregulatory network establishment method and device

Examples

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Embodiment 1

[0040] The embodiment of the present invention provides a method for establishing a cancer-specific co-regulatory network, such as figure 1 As shown, the method includes the following steps:

[0041] S101: Obtain TF regulation information and miRNA regulation information on target genes by TF and miRNA according to public databases.

[0042] Such as figure 2 As shown, the TF regulation information is obtained from public databases (for example: TRRUST, TRED, HTRIdb), and the TF regulation information includes TF-miRNA regulation information and TF-mRNA regulation information.

[0043] The miRNA regulatory information is obtained from public databases (eg miRTarBase, starBase, miRecords), and the miRNA regulatory information includes miRNA-TF regulatory information and miRNA-mRNA regulatory information.

[0044] S102: Establish a ternary regulatory network according to the TF regulation information and the miRNA regulation information.

[0045] A ternary regulatory network ...

Embodiment 2

[0062] A device for establishing a cancer-specific co-regulatory network provided by an embodiment of the present invention, such as image 3 shown, including:

[0063] The obtaining module 31 is used to obtain TF regulation information and miRNA regulation information on target genes by TF and miRNA according to public databases. TF regulation information is obtained from public databases (eg TRRUST, TRED, HTRIdb), and TF regulation information includes TF-miRNA regulation information and TF-mRNA regulation information. The miRNA regulatory information is obtained from public databases (eg miRTarBase, starBase, miRecords), and the miRNA regulatory information includes miRNA-TF regulatory information and miRNA-mRNA regulatory information.

[0064] The establishment module 32 is used for the user to establish a ternary regulatory network according to the TF regulation information and the miRNA regulation information. Merge the regulatory information obtained from public datab...

Embodiment 3

[0070] An electronic device provided by an embodiment of the present invention, such as Figure 4 As shown, the electronic device 4 includes a processor 41 and a memory 42, the memory stores a computer program that can run on the processor, and the processor implements the method provided by the first embodiment above when executing the computer program A step of.

[0071] see Figure 4 , the electronic device further includes: a bus 44 and a communication interface 43 , the processor 41 , the communication interface 43 and the memory 42 are connected through the bus 44 . The processor 41 is used to execute executable modules, such as computer programs, stored in the memory 42 .

[0072] Wherein, the memory 42 may include a high-speed random access memory (RAM, Random Access Memory), and may also include a non-volatile memory (non-volatile memory), such as at least one disk memory. The communication connection between the system network element and at least one other networ...

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Abstract

The invention provides a specific cancer coregulatory network establishment method and device and belongs to the technical field of regulatory network establishment. The method comprises the followingsteps: according to a public databank, acquiring TF regulatory information and miRNA regulatory information of TF and miRNA upon target genets; according to the TF regulatory information and the miRNA regulatory information, establishing a ternary regulatory network; recognizing FFLs in the ternary regulatory network, and acquiring FFLs recognition results; according to the FFLs recognition results and cancer genome expression information, screening, thereby obtaining a specific cancer miRNA-TF coregulatory network. According to the method, the ternary regulatory network of TF, miRNA and target genes is established, together with gene expression information, the miRNA-TF coregulatory network is obtained, and the accuracy of miRNA-TF coregulatory relationships is improved.

Description

technical field [0001] The present invention relates to the field of establishing a cancer regulatory network, in particular to a method and device for establishing a cancer-specific co-regulatory network. Background technique [0002] Transcription factors (TFs) and microRNAs (miRNAs) are regulatory factors that play an important role in the regulation of gene expression. Accumulating evidence shows that TFs and miRNAs work in tandem, and their dysregulation is associated with many diseases, including cancer. However, the existing studies on the co-regulation relationship of miRNA-TF lack the specific analysis of diseases (such as cancer), and lack of combination with gene expression data. The accuracy of the conclusion of the co-regulation relationship of miRNA-TF needs to be improved. Contents of the invention [0003] In view of this, the object of the present invention is to provide a method and device for establishing a cancer-specific co-regulatory network, which e...

Claims

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Application Information

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IPC IPC(8): G16B5/00G16B25/10
Inventor 李睿江陈河兵卢一鸣李昊江帅洪浩李宛莹黄昕赵诚辉张卓伯晓晨
Owner ACADEMY OF MILITARY MEDICAL SCI
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