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Production technology of high-purity teicoplanin

A technology for the production of teicoplanin, which is applied in the field of high-purity teicoplanin production technology, can solve the problems of many by-products and low production efficiency, and achieve the reduction of by-products, increase of yield, and increase of output Effect

Active Publication Date: 2019-04-12
JIANGSU JIUYANG BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But the existing teicoplanin production process has the defects of low production efficiency and many by-products

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A kind of production technology of high-purity teicoplanin, comprises the steps:

[0029] 1) preparing slant medium, seed medium and fermentation medium;

[0030] Wherein, the preparation method of the slant medium is: according to weight parts, take 5 parts of soluble starch, 1.5 parts of yeast extract, 1 part of glucose, 4 parts of agar powder, 0.1 part of calcium carbonate, 1 part of acetic acid, [Mg 2 (OH) 4 ]·mH 2 O·mH 2 O 2 parts of prepared slant medium, adjust the pH to be 7.0;

[0031] Wherein, the preparation method of the seed medium is as follows: according to parts by weight, take 7 parts of soluble starch, 5 parts of mannitol, 3 parts of yeast powder, and 5 parts of peptone to prepare the seed medium, and adjust the pH to 7.2;

[0032] Wherein, the preparation method of the fermentation medium is as follows: according to parts by weight, 3 parts of dextrin, 10 parts of soluble starch, 5 parts of soybean powder, 6 parts of corn steep liquor, and 0.5 par...

Embodiment 2

[0038] A kind of production technology of high-purity teicoplanin, comprises the steps:

[0039] 1) preparing slant medium, seed medium and fermentation medium;

[0040] Wherein, the preparation method of the slant medium is: according to parts by weight, take 8 parts of soluble starch, 0.5 parts of yeast extract, 3 parts of glucose, 2 parts of agar powder, 0.5 parts of calcium carbonate, 0.2 parts of acetic acid, [MgFe(OH) 4 ][SO 4 ] 0.5 mH 2 04 parts of preparation slant culture medium, adjust pH to be 6.8;

[0041] Wherein, the preparation method of the seed culture medium is: according to weight parts, take 10 parts of soluble starch, 3 parts of mannitol, 6 parts of yeast powder, and 2 parts of peptone to prepare the seed culture medium, and adjust the pH to 7.4;

[0042] Wherein, the preparation method of the fermentation medium is: according to the parts by weight, take 1 part of dextrin, 15 parts of soluble starch, 2 parts of soybean powder, 10 parts of corn steep l...

Embodiment 3

[0048] A kind of production technology of high-purity teicoplanin, comprises the steps:

[0049] 1) preparing slant medium, seed medium and fermentation medium;

[0050] Wherein, the preparation method of the slant medium is: according to the parts by weight, take 5 parts of soluble starch, 0.5 parts of yeast extract, 3 parts of glucose, 4 parts of agar powder, 0.1 part of calcium carbonate, 0.2 part of acetic acid, [Fe 2 (OH) 4 ][SO 4 ]·mH 2 0. 4 parts of preparation slant culture medium, adjust pH to be 7.0;

[0051] Wherein, the preparation method of the seed medium is as follows: according to parts by weight, take 7 parts of soluble starch, 3 parts of mannitol, 6 parts of yeast powder, and 5 parts of peptone to prepare the seed medium, and adjust the pH to 7.2;

[0052] Wherein, the preparation method of the fermentation medium is: according to the parts by weight, take 1 part of dextrin, 15 parts of soluble starch, 5 parts of soybean powder, 6 parts of corn steep liqu...

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Abstract

The present invention provides a production technology of high-purity teicoplanin. The production technology comprises the following steps: 1) a slant culture medium, a seed culture medium and a fermentation culture medium are prepared; 2) fermentation liquid is prepared; 3) an eluent is prepared; and 4) a finished product is obtained. Mg2+ can improve activity of glucose oxidase of actinoplanaceae cells, Fe3+ can promote growth of live bacteria and formation of endospores, and the Mg2+ and Fe3+ produce an active center through a synergistic action, effectively conduct catalytic fermentation and increase yield of the teicoplanin.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical engineering, in particular to a production process of high-purity teicoplanin. Background technique [0002] Teicoplanin, also known as Taikotamycin, was first discovered in 1975. It is a vancomycin family glycopeptide antibiotic obtained after fermentation and extraction of specific actinomycetes. It is an antibiotic mixture composed of many compounds with very similar chemical structures. [0003] Teicoplanin (teicoplanin) is a representative series of glycopeptide antibiotics. Clinically, it is mainly used to treat severe infections caused by sensitive bacteria such as Staphylococcus aureus and Streptococcus, such as endocarditis, osteomyelitis, sepsis, and infections of the respiratory tract, urinary tract, skin, and soft tissues. Its antibacterial mechanism is that the substance can hinder the mutual combination of peptidoglycan synthesis intermediates in the process of cell wall syn...

Claims

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Application Information

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IPC IPC(8): C07K9/00C12P21/02C12R1/045
CPCC12P21/005C07K9/008
Inventor 李军黄晔明国军郭绍定唐静陈军
Owner JIANGSU JIUYANG BIOLOGICAL PHARMA
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