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Medical sealing glue capable of promoting wound healing and preparation method thereof

A wound healing and sealant technology, which is applied in the field of medical sealant that can promote wound healing and its preparation, can solve the problem of lack of antibacterial and anti-infection effects, lack of antibacterial, anti-infection, low expansion, Bond strength and other issues, to achieve the effect of promoting rapid healing, fast gelation speed, and strong mechanical properties

Active Publication Date: 2019-04-05
SHANDONG BRANDEN MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hemostatic material has the advantages of in-situ cross-linking, mild reaction conditions, adjustable gel speed, low swelling, and high bonding strength. Disadvantages of bacteria and anti-infection effects
[0006] The current commercially available polyethylene glycol hydrogel products, such as Duraseal and Adherus, also have the disadvantages of promoting wound healing slowly, and having no antibacterial and anti-infection effects

Method used

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  • Medical sealing glue capable of promoting wound healing and preparation method thereof
  • Medical sealing glue capable of promoting wound healing and preparation method thereof
  • Medical sealing glue capable of promoting wound healing and preparation method thereof

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Embodiment Construction

[0022] The technical solution of the present invention will be further described in detail below in conjunction with examples and comparative examples. However, the present invention is not limited by these specific examples. The methods used in the examples are conventional methods unless otherwise specified. In the present invention, the detection method of the hydrogel is adopted as follows.

[0023] Gelling time detection:

[0024] (1) Preparation of the sample to be tested: Dissolve the first component containing the nucleophilic functional group in a buffer solution with a pH value of 7-12 to obtain solution A, and transfer solution A to a syringe of a two-component mixer Then dissolve the second component containing the electrophilic functional group in a buffer solution with a pH value of 2-8 to obtain solution B, transfer solution B to another syringe, and install the two-component mixer for standby. (2) Gelling time detection: evenly push the two-component mixer, ...

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Abstract

The invention discloses in-situ crosslinking shaping medical sealing glue capable of promoting wound healing and a preparation method thereof. The medical sealing glue has the gelling time being 1 to10s, the swelling degree being 0 to 100 percent, the cracking intensity being 100 to 250mmHg and the degradation time being 0.5 to 300 days. The medical sealing glue is prepared from two ingredients through being physically mixed by a mixing tool and then being subjected to covalent cross-linking; a first ingredient is a nucleophilic ingredient; a second ingredient is an electrophilic ingredient.The medical nucleophilic ingredient contains exosomes or hyaluronic acid and chitosan, so that the medical sealing glue has the effect of promoting the wound healing; the antibacterial and anti-infection effects are achieved.

Description

technical field [0001] The invention belongs to the technical field of medical sealant, and relates to a medical sealant capable of promoting wound healing and a preparation method thereof. The medical sealant of the present application can promote wound healing and at the same time have the effects of inhibiting bacteria and preventing infection. Background technique [0002] In surgical operations, fast, effective and safe tissue closure is one of the key factors to ensure the success of the operation. Excellent medical sealant can control wound bleeding or interstitial fluid, ensure clear surgical field of view, improve surgical efficiency, and accelerate postoperative recovery of patients. [0003] A variety of medical sealants have been developed at home and abroad, mainly including animal-derived medical glue, semi-synthetic material medical glue and synthetic material medical glue, among which animal-derived medical glue is divided into fibrin glue containing thrombi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/04A61L24/06A61L24/08
CPCA61L24/0005A61L24/001A61L24/0031A61L24/046A61L24/06A61L24/08A61L2400/04C08L5/08C08L71/02C08L39/00C08L77/04A61L24/0015A61L24/043A61L2300/64A61L2400/06C08L79/02A61K35/28
Inventor 张海军袁坤山王如蒙鲁手涛刘黎明曹文瑞周超尹玉霞侯文博段翠海刘光
Owner SHANDONG BRANDEN MEDICAL DEVICE
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