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Use of proanthocyanidin compounds in product for prevention and/or treatment of insulin resistance

A technology for insulin resistance and proanthocyanidins, which is applied to medical preparations containing active ingredients, plant/algae/fungus/moss components, and applications, can solve the problems of in-depth research on chemical components and active effects, and no reporting, etc. The effect of increasing the rate of ATP synthesis, reducing the level of reactive oxygen species, and increasing the phosphorylation level of AKT protein

Inactive Publication Date: 2019-04-02
YANTAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in recent years, the researches on the chemical constituents and pharmacological effects of Iris are mostly limited to the radiation-sensitizing effect of echinacea, while the research on other chemical constituents and active effects has not been in-depth and has not been reported.

Method used

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  • Use of proanthocyanidin compounds in product for prevention and/or treatment of insulin resistance
  • Use of proanthocyanidin compounds in product for prevention and/or treatment of insulin resistance
  • Use of proanthocyanidin compounds in product for prevention and/or treatment of insulin resistance

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0046] The application of the present invention will be further described through specific examples and experiments below, and the effect of the proanthocyanidins on improving insulin resistance will be verified and explained.

[0047] Experimental materials and preparation:

[0048] 1. Experimental materials, reagents and instruments

[0049] The tested samples included 6 procyanidin compounds: Catechin (P-1), Epicatechin (P-2), Procyanidin B7 (P-3), Procyanidin B6 (P-4), Procyanidin B3 (P-5), Procyanidin B1(P-6) is all prepared by separating and purifying from the seeds of Iris japonica, and the purity detected by HPLC is more than 95%. Its chemical structural formula is as follows:

[0050]

[0051] Materials and reagents used in the experiment of the present invention are shown in Table 1.

[0052] Table 1 Materials and Reagents

[0053]

[0054]

[0055]

[0056] (1) 2-NBDG preparation

[0057] The 2-NBDG powder was dissolved in DMSO to prepare a 10 mM sto...

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Abstract

The present invention provides the use of proanthocyanidin compounds for preparation of a drug for diseases associated with insulin resistance. The proanthocyanidin compound is extracted from the seeds of the iris lacteal, and the compound has an effect of improving insulin resistance, and can be used for preparing the drug for preventing or treating the disease associated with insulin resistance.

Description

technical field [0001] The invention belongs to the field of development of medicinal active compounds in plants, and in particular relates to the use of proanthocyanidin compounds in the preparation of medicines for diseases related to insulin resistance. Background technique [0002] Insulin resistance (Insulin resistance, IR) refers to the target organs of insulin action, such as liver, muscle and adipose tissue, etc., which are less sensitive to insulin, resulting in a decrease in the rate of glucose and lipid metabolism. Under normal physiological conditions, insulin can promote the uptake of glucose by the target organs of insulin action, such as liver, skeletal muscle and adipose tissue, so that the excess glucose in the body can be rapidly utilized and transported. When the body's insulin secretion is insufficient or the pancreatic islet cells cannot secrete insulin, the sensitivity of the insulin target tissue to insulin drops sharply, causing the blood sugar level ...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61P5/50A61P3/10A61P9/12A61P3/06A61P9/00A61K36/88A23L33/105
CPCA23V2002/00A61K31/353A61K36/88A23L33/105A61P3/06A61P3/10A61P5/50A61P9/00A61P9/12C07B2200/07A23V2200/328A23V2250/2132
Inventor 李刚王洪伦王振华李忌马成俊
Owner YANTAI UNIV
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