Ozone oleogel for gynecological inflammation and preparation method of ozone oleogel
A technology of gynecological inflammation and ozone oil, which is applied in the field of ozone oil gel for gynecological inflammation and its preparation, can solve the problems of poor patient acceptance, poor drug absorption, and easy drug resistance, and achieve improved curative effect and long-lasting Longer, lessen the effects of chemical and physical stimuli
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[0029] Preferably, a kind of preparation method of the ozone oil gel that is used for gynecological inflammation as mentioned above, comprises the following steps:
[0030] Step 1) adding 1 to 5 parts by weight of zedoary oil and 0.1 to 1.5 parts by weight of ozone oil into the mixed solution of glycerin and propylene glycol and stirring;
[0031] Step 2) adding a solubilizer to the solution in step 1), followed by stirring for 30 minutes;
[0032] Step 3) adding an aqueous solution of hydroxypropyl-β-cyclodextrin to the solution in step 2), stirring for 30 minutes to obtain a uniform solution, and then adding it to a high-speed homogeneous emulsifier for stirring to obtain the first emulsion;
[0033] Step 4) honeysuckle with 5-15 parts by weight, Sophora flavescens with 2-10 parts by weight, Fructus Cnidii with 2-10 parts by weight, Motherwort with 2-10 parts by weight, 2 parts by weight ~8 parts of Zanthoxylum bungeanum, 2~6 parts by weight of alum are added to the ethanol...
Embodiment 1
[0065] Step 1) adding zedoary oil of 1 part by weight and ozone oil of 0.1 part by weight into the mixed solution of glycerin and propylene glycol and stirring, wherein the part by weight of glycerin is 1 part, the part by weight of propylene glycol is 1 part, ozone The concentration of ozone in oil is 0.05ppm;
[0066] Step 2) Add 1 part by weight of Tween 80 to the solution in step 1), and then stir for 30 minutes;
[0067] Step 3) Add 80 parts by weight of hydroxypropyl-β-cyclodextrin aqueous solution to the solution in step 2), stir for 30 minutes to obtain a uniform solution, and then add it to a high-speed homogeneous emulsifier for stirring to obtain the first emulsion;
[0068] Step 4) honeysuckle that is 5 parts by weight, Sophora flavescens that is 2 parts by weight, Fructus Cnidii that are 2 parts by weight, Motherwort that are 2 parts by weight, Chinese prickly ash that are 2 parts by weight, 2 parts by weight Parts of alum is added in the ethanol solution for ext...
Embodiment 2
[0071] Step 1) 5 parts by weight of zedoary oil and 1.5 parts of ozone oil are added to the mixed solution of glycerin and propylene glycol and stirred, wherein the weight part of glycerin is 10 parts, the weight part of propylene glycol is 6 parts, and the ozone The concentration of ozone in oil is 0.15ppm;
[0072] Step 2) Add 4 parts by weight of Tween 80 to the solution in step 1), and then stir for 30 minutes;
[0073] Step 3) Add 90 parts by weight of an aqueous solution of hydroxypropyl-β-cyclodextrin to the solution in step 2), stir for 30 minutes to obtain a uniform solution, and then add it to a high-speed homogeneous emulsifier for stirring to obtain the first emulsion;
[0074] Step 4) honeysuckle that is 15 parts by weight, Sophora flavescens that is 10 parts by weight, Fructus Cnidii that is 10 parts by weight, motherwort that is 10 parts by weight, Zanthoxylum bungeanum that is 8 parts by weight, 6 parts by weight Parts of alum is added in the ethanol solution ...
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