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Method for detecting quality of sanajon oral solution with qualitative and quantitative evaluation

A quality detection method and detection method technology, which is applied in the HPLC fingerprint detection of Sanle Porridge Oral Liquid and in the field of drug quality control, can solve the problems of difficulty in comprehensive quality control and less research on chemical components, and achieve good separation and ensure High-quality, high-precision results

Active Publication Date: 2019-03-26
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0003] Sanlejiang Oral Liquid is rich in polyphenols, but there are few studies on its chemical composition, and the quality control only uses Corilagin as an internal control index, so it is difficult to fully control its quality

Method used

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  • Method for detecting quality of sanajon oral solution with qualitative and quantitative evaluation
  • Method for detecting quality of sanajon oral solution with qualitative and quantitative evaluation
  • Method for detecting quality of sanajon oral solution with qualitative and quantitative evaluation

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Experimental program
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Embodiment 1

[0035] Embodiment 1 Establishment of the inventive method

[0036] (1) Establishment of HPLC fingerprint of Sanle Porridge Oral Liquid and methodological investigation

[0037] 1.1 Preparation of solution

[0038] 1.1.1 Preparation of mixed reference solution

[0039] Accurately weigh each reference substance, add 50% methanol water (meanol accounts for 50% of the total solution) to prepare 846.0 μg of gallic acid, 214.5 μg of gallocatechin, 130.75 μg of epicatechin, and 201.0 μg of corilagin per 1 mL. μg, a mixed solution of 92 μg of ellagic acid.

[0040] 1.1.2 Preparation of the test solution

[0041] Accurately measure 5 mL of Sanle pulp to a 25 mL volumetric flask, add 50% methanol water (meanol accounts for 50% of the total solution) to the scale line, shake well, filter with a 0.22 μm microporous membrane, and take the filtrate as the test solution .

[0042] 1.1.3 Preparation of myrobalan and emblica solution

[0043] Weigh 5g each of myrobalan and emblica powder...

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Abstract

The invention discloses a HPLC fingerprint detection method of a sanajon oral solution. The fingerprint has the advantages of more appearance, good resolution, good repeatability and high precision, and provides effective guarantee to comprehensive monitor on the quality of a sanajon oral solution. The extraction method and chromatographic condition of the fingerprint detection method are utilizedto detect content of five active ingredients in the sanajon oral solution, including gallic acid, allocatechine, picatechin, corilagin and ellagic acid, and realizes qualitative and quantitative researches on the sanajon oral solution.

Description

technical field [0001] The invention relates to an HPLC fingerprint detection method for Sanle pulp oral liquid, and belongs to the technical field of drug quality control methods. Background technique [0002] The prescription of Sanle Porridge is derived from Sanguo Decoction (also known as Zhebu Song Decoction), a famous Tibetan medicine prescription. In Tibetan medicine, they are respectively called Mole, Helile and Pilile, also known as Sanlejiang. In traditional Tibetan medicine, Sanguo Decoction has a significant effect on plague and plateau polycythemia [1] , is regarded as a tonic and strong drug; in modern medicine, it is found that it has a good immune regulation function, and it is effective for hyperlipidemia [2] , tumor [3] etc. have a certain therapeutic effect. In the 1990s, using emblica and myrobalan as raw materials, adding L-arginine, L-aspartic acid, honey and other auxiliary materials, developed Sanle pulp oral administration with functions of anti-...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/047
Inventor 张定堃林俊芝韩丽姜红韩雪黄浩洲
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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